6533b82efe1ef96bd129340e
RESEARCH PRODUCT
Biological properties of extracellular vesicles and their physiological functions
Juan M. Falcón-pérezIrene M. GhobrialAija LineEva RohdeEva RohdeFrancesco CappelloIrina NazarenkoMaría Yáñez-móSaara LaitinenMayda GurselMaría MittelbrunnKrisztina BuzasKrisztina BuzasMario GimonaMario GimonaErzsébet LigetiAn HendrixIhsan GurselMarie Stampe OstenfeldAntonio MarcillaJoana CarvalhoJoana CarvalhoEva-maria Krämer-albersGeorg LippsFrancisco Sánchez-madridThomas LenerThomas LenerCarla OliveiraCarla OliveiraÉVa PállingerFrancesc E. BorràsSusanne G. Van Der GreinOlivier De WeverVeronika Kralj-igličBernd GiebelAnabela Cordeiro Da SilvaAnabela Cordeiro Da SilvaEsther N. M. Nolte-‘t HoenNuno SantarémNuno SantarémWillem StoorvogelMarina RigauHernando A. Del PortilloHernando A. Del PortilloKatsutoshi KokubunMarca H. M. WaubenAlicia LlorenteApolonija Bedina ZavecEva ColasKatharina SchallmoserKatharina SchallmoserMaja KosanovićPeter KierulfJaume ReventósJaume ReventósMireia OlivanJan LötvallEdit I. BuzásEnriqueta CasalMichael W. GranerPia SiljanderStefano FaisCecilia LässerMarei SammarNiels H. H. HeegaardNiels H. H. HeegaardLorraine O'driscollRoman ŠTukeljTuula A. NymanZoraida AndreuMateja Manček-keberM. Helena VasconcelosM. Helena Vasconcelossubject
ProteomicsCellular distributionMATURE DENDRITIC CELLSReviewReview ArticleUrineEmbryo developmentMonocyteProtein processingVascular biologyFecesVesícules seminalsSYNCYTIOTROPHOBLAST MICROVILLOUS MEMBRANESCell selectionPregnancyT lymphocyteBileCELL-DERIVED EXOSOMESBiogenesisLung lavageUterus fluidInnate immunityMale genital systemlcsh:CytologyMicrovesicleOUTER-MEMBRANE VESICLESBlood clottingprokaryoteEukaryotaExtracellular vesicleRNA analysisCell biologyBloodCerebrospinal fluidLiver metabolismmicrovesicleMorphogenHumanNervous systemCell signalingBreast milkNatural killer cellFisiologiaExtracellular vesiclesExosomelcsh:QH573-671SalivaBiologyBiology and Life SciencesDNAPlantRNA transportCell functionMacrophageMolecular biologyPhysiologyMedizinProteomicsFACTOR PATHWAY INHIBITOReukaryoteProtein glycosylationExtracellular spaceTissue repairEspai extracel·lularReticulocyteSeminal plasmaMesenchymal stem cellAntigen presenting cellSeminal vesiclesNose mucusBiofilmNeutrophilMicroRNAPLANT-MICROBE INTERACTIONSLipidAmnion fluidProkaryotamicroparticleCell interactionCell transporteukaryote exosome extracellular vesicle microparticle microvesicle physiology prokaryoteBone mineralizationMicroorganismHistologyAdaptive immunityMembrane vesicleComputational biologyMembrane receptorBiologyStressCell communicationMast cellMESENCHYMAL STEM-CELLSHUMAN ENDOTHELIAL-CELLSexosomeCytokineSynovial fluidCell BiologyNonhumanIMMUNE-MODULATORY FEATURESReview articleDNA contentphysiologyRNAINTESTINAL EPITHELIAL-CELLSextracellular vesicleBody fluidLectinBiogenesisdescription
The authors wish to thank Dr R Simpson and Dr D Taylor for critical reading of the manuscript and acknowledge the Horizon 2020 European Cooperation in Science and Technology programme and its support of our European Network on Microvesicles and Exosomes in Health & Disease (ME-HaD; BM1202 www.cost.eu/COST_Actions/bmbs/Actions/BM1202). In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-05-01 |