0000000000001510

AUTHOR

Barbara Malenica

showing 2 related works from this author

Altered expression of nonclassical HLA class Ib antigens in human renal cell carcinoma and its association with impaired immune response

2003

Abstract An optimal antitumoral immune response requires the activation of both CD8 + and CD4 + T lymphocytes by the peptide antigen presentation via the human leukocyte antigen (HLA) class I and class II molecules, respectively. Downregulation or loss of HLA molecules has been found in human renal cell carcinoma (RCC) and provides a strategy of these tumors to evade T-cell mediated immunosurveillance. In addition, a tumor-specific upregulation of HLA-G has been recently described in RCC, which also leads to an impaired immune response. We here summarize the frequency of the constitutive and/or interferon-γ (IFN-γ) inducible expression of nonclassical HLA class Ib antigens in RCC cell lines…

Blotting WesternImmunologyHuman leukocyte antigenBiologyurologic and male genital diseasesInterferon-gammaImmune systemAntigenDownregulation and upregulationHLA AntigensInterferonTumor Cells CulturedmedicineHumansImmunology and AllergyRNA MessengerCarcinoma Renal CellHLA-G AntigensKidneyReverse Transcriptase Polymerase Chain ReactionHistocompatibility Antigens Class IAntibodies MonoclonalGeneral MedicineFlow CytometryKidney NeoplasmsRecombinant ProteinsUp-RegulationGene Expression Regulation NeoplasticKiller Cells NaturalImmunosurveillanceBlotting Southernmedicine.anatomical_structureImmunologyCD8T-Lymphocytes Cytotoxicmedicine.drugHuman Immunology
researchProduct

Identification of fatty acid binding proteins as markers associated with the initiation and/or progression of renal cell carcinoma

2005

Renal cell carcinoma (RCC) representing the most common neoplasia of the kidney in Western countries is a histologic diverse disease with an often unpredictable course. The prognosis of RCC is worsened with the onset of metastasis, and the therapies currently available are of limited success for the treatment of metastatic RCC. Although gene expression analyses and other methods are promising tools clarifying and standardizing the pathological classification of RCC, novel innovative molecular markers for the diagnosis, prognosis, and for the monitoring of this disease during therapy as well as potential therapeutic targets are urgently needed. Using proteome-based strategies, a number of RC…

DiseaseBiologyFatty Acid-Binding ProteinsKidneyurologic and male genital diseasesmedicine.disease_causeBiochemistryMetastasisReference ValuesRenal cell carcinomaCell Line TumorBiomarkers TumormedicineCarcinomaHumansElectrophoresis Gel Two-DimensionalUrotheliumCarcinoma Renal CellneoplasmsMolecular BiologyDNA PrimersKidneyReverse Transcriptase Polymerase Chain ReactionPrognosismedicine.diseaseImmunohistochemistryKidney Neoplasmsfemale genital diseases and pregnancy complicationsGene Expression Regulation Neoplasticmedicine.anatomical_structureImmunologyDisease ProgressionCancer researchUrotheliumCarrier ProteinsCarcinogenesisKidney diseasePROTEOMICS
researchProduct