6533b831fe1ef96bd1298738

RESEARCH PRODUCT

Identification of fatty acid binding proteins as markers associated with the initiation and/or progression of renal cell carcinoma

Barbara MalenicaBarbara SeligerBarbara SeligerAlois HarderMonica ZobawaWalburgis BrennerFriedrich LottspeichAngelika AckermannJürgen BukurMichael KerstenThomas M. HalderRudolf LichtenfelsRudolf LichtenfelsDerek Atkins

subject

DiseaseBiologyFatty Acid-Binding ProteinsKidneyurologic and male genital diseasesmedicine.disease_causeBiochemistryMetastasisReference ValuesRenal cell carcinomaCell Line TumorBiomarkers TumormedicineCarcinomaHumansElectrophoresis Gel Two-DimensionalUrotheliumCarcinoma Renal CellneoplasmsMolecular BiologyDNA PrimersKidneyReverse Transcriptase Polymerase Chain ReactionPrognosismedicine.diseaseImmunohistochemistryKidney Neoplasmsfemale genital diseases and pregnancy complicationsGene Expression Regulation Neoplasticmedicine.anatomical_structureImmunologyDisease ProgressionCancer researchUrotheliumCarrier ProteinsCarcinogenesisKidney disease

description

Renal cell carcinoma (RCC) representing the most common neoplasia of the kidney in Western countries is a histologic diverse disease with an often unpredictable course. The prognosis of RCC is worsened with the onset of metastasis, and the therapies currently available are of limited success for the treatment of metastatic RCC. Although gene expression analyses and other methods are promising tools clarifying and standardizing the pathological classification of RCC, novel innovative molecular markers for the diagnosis, prognosis, and for the monitoring of this disease during therapy as well as potential therapeutic targets are urgently needed. Using proteome-based strategies, a number of RCC-associated markers either over-expressed or down-regulated in tumor lesions in comparison to the normal epithelium have been identified which have been implicated in tumorigenesis, but never linked to the initiation and/or progression of RCC. These include members of the fatty acid binding protein family, which have the potential to serve as diagnostic or prognostic markers for the screening of RCC patients.

yearjournalcountryeditionlanguage
2005-05-14PROTEOMICS
https://doi.org/10.1002/pmic.200401264