Effect of cadmium on MDA-MB231 breast cancer cells

We demonstrated that treatment of estrogen receptor-negative (ER-) MDA-MB231 breast cancer cells with 5 M Cd for 96h resulted in an about 50% reduction of cell number

Response to cadmium stress by neoplastic and immortalized human breast cells: evidence for different modulation of gene expression.

PTHrP [38-94]-amide is a DNA-binding factor: cytogenetic and molecular evidence and biological effect on normal and neoplastic human breast cells

PTHrP [38-94] is a survival- and growth-promoting factor for non-tumoral breast epithelial cells.

Type V collagen regulates apoptosis-related gene expression in breast cancer cells

Effect of cadmium and manganese on gene expression and proliferative/invasive ability of tumoral and immortalized epithelial cells form the human breast

Espressione cadmio-dipendente di AEG-1, c-fos e c-jun in cellule tumorali mammarie umane

Effect of mid-region PTHrP on tumoral and immortalized human breast cells

Il PTHrP [38-94]-amide è un fattore “DNA-binding”: dati citogenetica e molecolari ed effetto biologico su cellule epiteliali mammarie immortalizzate e neoplastiche

Rip-1 regulation of caspase expression in PTHrP [38-94]-treated MDA-MB231 breast cancer cells

Cadmium effect on gene expression by MDA-MB231 breast cancer cells: evidence for down-regulation of AEG-1

p38 MAPK in cadmium-treated MDA-MB231 breast cancer cells

Involvement of PKCη in type V collagen-induced apoptosis on 8701-BC breast cancer cells

PTHrP [38-94] and gene expression of MDA-MB231 breast cancer cells

Rip-1 controlla l’espressione delle caspasi in cellule MDA-MB231 trattate con PTHrP[38-94]-amide

P38 MAPK pathway is involved in cadmium response by MDA-MB231 breast cancer cells

Espressione cadmio-dipendente di AEG-1 in cellule tumorali mammarie umane

Aspects of the cytotoxic activity of PTHrP [38-94]-amide on human breast cancer cells

Mid-region PTHrP and gene expression of MDA-MB231 breast cancer cells

Type V collagen is known to be over-deposited in the stroma of ductal infiltrating carcinomas of the breast. When used as a substrate, type V collagen restrains growth and invasion, and affects gene expression of 8701-BC ductal infiltrating carcinomas cells. Here we supplement existing data by demonstrating type V collagen dependent upregulation of capn2 gene expression in 8701-BC cells through differential display-PCR and Western blot assays. Furthermore, we suggest that our data obtained by centrifugal sedimentation and electrophoresis strongly suggest a correlation between calpain overproduction and DNA fragmentation, since the incubation with calpain inhibitor partly reverts the latter.