0000000000003656

AUTHOR

Barbara Liori

showing 2 related works from this author

Monitoring neonatal fungal infection with metabolomics

2014

Abstract The objective of our study was to evaluate the capability of the metabolomics approach to identify the variations of urine metabolites over time related to the neonatal fungal septic condition. The study population included a clinical case of a preterm neonate with invasive fungal infection and 13 healthy preterm controls. This study showed a unique urine metabolic profile of the patient affected by fungal sepsis compared to urine of controls and it was also possible to evaluate the efficacy of therapy in improving patient health.

Fungal infectionmedicine.medical_specialtyUrineInfant Newborn DiseasessepsisSepsisSettore MED/38 - Pediatria Generale E SpecialisticaMetabolomicsIntensive Care Units NeonatalmedicineHumansMetabolomicsIntensive care medicinePrincipal Component AnalysisPatient affectedbusiness.industryInfant NewbornObstetrics and Gynecologymedicine.diseaseItalyMycosesfungal infectionsPediatrics Perinatology and Child HealthMetabolomePopulation studyMetabolomic; fungal infections; PrematurityFungal sepsisClinical caseneonatePrematuritybusinessBiomarkersMetabolic profilemetabolomicThe Journal of Maternal-Fetal & Neonatal Medicine
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Urinary (1)H-NMR and GC-MS metabolomics predicts early and late onset neonatal sepsis.

2014

The purpose of this article is to study one of the most significant causes of neonatal morbidity and mortality: neonatal sepsis. This pathology is due to a bacterial or fungal infection acquired during the perinatal period. Neonatal sepsis has been categorized into two groups: early onset if it occurs within 3-6 days and late onset after 4-7 days. Due to the not-specific clinical signs, along with the inaccuracy of available biomarkers, the diagnosis is still a major challenge. In this regard, the use of a combined approach based on both nuclear magnetic resonance (H-1-NMR) and gas-chromatography-mass spectrometry (GC-MS) techniques, coupled with a multivariate statistical analysis, may hel…

Malemedicine.medical_specialtyPathologyMagnetic Resonance SpectroscopySepsiUrinary systemLate onsetMetabolomicDiseaseMass SpectrometrySepsisSettore MED/38 - Pediatria Generale E SpecialisticaInternal medicineSepsismedicineMetabolomeHumansNeonatal sepsisbusiness.industryCase-control studyInfant NewbornObstetrics and Gynecologymedicine.diseaseNewbornPrognosisCase-Control StudiesPediatrics Perinatology and Child HealthMetabolomePopulation studyFemalebusinessNeonatal infectionBiomarkersEarly human development
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