6533b7d9fe1ef96bd126cc8a
RESEARCH PRODUCT
Monitoring neonatal fungal infection with metabolomics
Vassilios FanosMarco ZaffanelloAngelica DessìMario GiuffrèMauro StronatiAntonio NotoPierluigi CaboniGiovanni CorselloFrancesca SerrainoBarbara Liorisubject
Fungal infectionmedicine.medical_specialtyUrineInfant Newborn DiseasessepsisSepsisSettore MED/38 - Pediatria Generale E SpecialisticaMetabolomicsIntensive Care Units NeonatalmedicineHumansMetabolomicsIntensive care medicinePrincipal Component AnalysisPatient affectedbusiness.industryInfant NewbornObstetrics and Gynecologymedicine.diseaseItalyMycosesfungal infectionsPediatrics Perinatology and Child HealthMetabolomePopulation studyMetabolomic; fungal infections; PrematurityFungal sepsisClinical caseneonatePrematuritybusinessBiomarkersMetabolic profilemetabolomicdescription
Abstract The objective of our study was to evaluate the capability of the metabolomics approach to identify the variations of urine metabolites over time related to the neonatal fungal septic condition. The study population included a clinical case of a preterm neonate with invasive fungal infection and 13 healthy preterm controls. This study showed a unique urine metabolic profile of the patient affected by fungal sepsis compared to urine of controls and it was also possible to evaluate the efficacy of therapy in improving patient health.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-01-01 | The Journal of Maternal-Fetal & Neonatal Medicine |