0000000000004708

AUTHOR

Teresa Olivar

showing 2 related works from this author

2-sulfonyliminodihydropyrimidines: a novel class of analgesic compounds.

2008

A series of 2-sulfonyliminodihydropyrimidine derivatives have been synthesized and evaluated in vivo for their antinociceptive and anti-inflammatory activities. The results were compared with that of acetyl salicylic acid. Compounds 6Ab-d and 6Be displayed an interesting analgesic profile in the acetic acid-induced abdominal contractions test. Based on the results of the carrageenan-hind paw edema test, compound 6Af showed potential anti-inflammatory activity.

MaleMagnetic Resonance SpectroscopyStereochemistryAnalgesicAnti-Inflammatory AgentsDrug Evaluation PreclinicalPharmaceutical SciencePainPharmacologychemistry.chemical_compoundMiceStructure-Activity RelationshipIn vivoDrug DiscoveryStructure–activity relationshipAnimalsEdemaAnalgesicsMolecular StructureChemistryRatsNociceptionPyrimidinesFemaleSalicylic acidPaw edemaArchiv der Pharmazie
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ChemInform Abstract: 2-Sulfonyliminodihydropyrimidines: A Novel Class of Analgesic Compounds.

2009

A series of 2-sulfonyliminodihydropyrimidine derivatives have been synthesized and evaluated in vivo for their antinociceptive and anti-inflammatory activities. The results were compared with that of acetyl salicylic acid. Compounds 6Ab-d and 6Be displayed an interesting analgesic profile in the acetic acid-induced abdominal contractions test. Based on the results of the carrageenan-hind paw edema test, compound 6Af showed potential anti-inflammatory activity.

chemistry.chemical_compoundNociceptionIn vivoChemistryAnalgesicGeneral MedicinePharmacologySalicylic acidPaw edemaChemInform
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