2-sulfonyliminodihydropyrimidines: a novel class of analgesic compounds.

6533b825fe1ef96bd12828ea

RESEARCH PRODUCT

2-sulfonyliminodihydropyrimidines: a novel class of analgesic compounds.

Encarna Castillo José Sepúlveda-arques M. Eugenia González-rosende Teresa Olivar

subject

Male Magnetic Resonance Spectroscopy Stereochemistry Analgesic Anti-Inflammatory Agents Drug Evaluation Preclinical Pharmaceutical Science Pain Pharmacology chemistry.chemical_compound Mice Structure-Activity Relationship In vivo Drug Discovery Structure–activity relationship Animals Edema Analgesics Molecular Structure Chemistry Rats Nociception Pyrimidines Female Salicylic acid Paw edema

description

A series of 2-sulfonyliminodihydropyrimidine derivatives have been synthesized and evaluated in vivo for their antinociceptive and anti-inflammatory activities. The results were compared with that of acetyl salicylic acid. Compounds 6Ab-d and 6Be displayed an interesting analgesic profile in the acetic acid-induced abdominal contractions test. Based on the results of the carrageenan-hind paw edema test, compound 6Af showed potential anti-inflammatory activity.

year	journal	country	edition	language
2008-11-01	Archiv der Pharmazie

10.1002/ardp.200800107 https://pubmed.ncbi.nlm.nih.gov/18816588

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