ChemInform Abstract: 2-Sulfonyliminodihydropyrimidines: A Novel Class of Analgesic Compounds.

6533b85bfe1ef96bd12ba953

RESEARCH PRODUCT

ChemInform Abstract: 2-Sulfonyliminodihydropyrimidines: A Novel Class of Analgesic Compounds.

M. Eugenia González-rosende Teresa Olivar Encarna Castillo José Sepúlveda-arques

subject

chemistry.chemical_compound Nociception In vivo Chemistry Analgesic General Medicine Pharmacology Salicylic acid Paw edema

description

A series of 2-sulfonyliminodihydropyrimidine derivatives have been synthesized and evaluated in vivo for their antinociceptive and anti-inflammatory activities. The results were compared with that of acetyl salicylic acid. Compounds 6Ab-d and 6Be displayed an interesting analgesic profile in the acetic acid-induced abdominal contractions test. Based on the results of the carrageenan-hind paw edema test, compound 6Af showed potential anti-inflammatory activity.

year	journal	country	edition	language
2009-03-10	ChemInform

https://doi.org/10.1002/chin.200910148

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