Factores relacionados con el riesgo de trombosis en pacientes con lupus y positividad para anticuerpos antifosfolipídicos

Fundamento y objetivo Los anticuerpos antifosfolipidicos (AAF) aparecen con frecuencia asociados al lupus eritematoso sistemico (LES), con lo que aumenta el riesgo de trombosis. El objetivo del presente trabajo ha sido analizar el perfil temporal y los factores de riesgo de accidentes tromboticos en pacientes con LES. Pacientes y metodo Se ha realizado un estudio retrospectivo en 102 pacientes con LES controlados en nuestra unidad –edad media de 37,5 anos (extremos, 8-85); 90 mujeres–, con una mediana de seguimiento de 72 meses (extremos, 9-324). Del total de la muestra, 41 (40,2%) presentaban AAF positivos. La probabilidad de presentar un accidente trombotico durante el seguimiento se calc…

Anomalías de la vena cava y trombosis venosa profunda

Resumen Estudio prospectivo de 116 pacientes menores de 50 anos con trombosis venosa profunda (TVP) de los miembros inferiores, en el que se valora la presencia de anomalias de la vena cava inferior (VCI) como factor de riesgo de la TVP. Se practico a todos una eco-Doppler; cuando tenian afeccion iliaca se realizaba tambien flebografia, y cuando el drenaje a la VCI era deficiente, se completaba el estudio con resonancia magnetica o tomografia computarizada. En todos los pacientes tambien se realizaron las siguientes determinaciones: antitrombina, deficit de proteina C y S, factor V Leiden, protrombina G20210A y anticuerpos antifosfolipidicos. Tambien se valoraron los factores de riesgo adqu…

CX3CR1/CX3CL1 Axis Mediates Platelet–Leukocyte Adhesion to Arterial Endothelium in Younger Patients with a History of Idiopathic Deep Vein Thrombosis

AbstractMechanisms linking deep vein thrombosis (DVT) and subclinical atherosclerosis and risk of cardiovascular events are poorly understood. The aim of this study was to investigate the potential impact of CX3CR1/CX3CL1 axis in DVT-associated endothelial dysfunction. The study included 22 patients (age: 37.5 ± 8.2 years) with a history of idiopathic DVT and without known cardiovascular risk factors and 23 aged-matched control subjects (age: 34 ± 7.8 years). Flow cytometry was used to evaluate peripheral markers of platelet activation, leukocyte immunophenotypes and CX3CR1/CX3CL1 expression in both groups. A flow chamber assay was employed to measure leukocyte arrest under dynamic conditio…

Estudio prospectivo de los factores de riesgo y las características clínicas de la enfermedad tromboembólica en pacientes jóvenes

Fundamento y objetivo El objetivo del presente trabajo es el estudio de los factores de riesgo de la enfermedad tromboembolica en pacientes jovenes y la descripcion de sus caracteristicas clinicas segun la etiologia Pacientes y metodo Estudio prospectivo de 100 pacientes menores de 50 anos, no afectados de neoplasias ni enfermedades cronicas, que requirieron ingreso hospitalario por enfermedad tromboembolica. El diagnostico morfologico se realizo con eco-Doppler, flebografia, gammagrafia pulmonar o tomografia computarizada. Los factores de riesgo valorados fueron deficit de antitrombina, deficit de proteina C y S, factor V Leiden, protrombina G20210A, hiperhomocisteinemia, elevacion del inh…

Should we look for silent pulmonary embolism in patients with deep venous thrombosis?

Background Asymptomatic or silent pulmonary embolism (S-PE) in patients with deep vein thrombosis has been the focus of numerous publications with the objective of determining the incidence of S-PE and assessing whether its existence has any clinical or therapeutic consequences that outweigh the risks associated with the diagnostic tests performed and the increased healthcare costs. The objectives were to assess the incidence of S-PE using computed tomography angiogram (CTA), to understand the epidemiological factors that might trigger embolism, and to assess whether D-dimer (DD) predicts the existence of S-PE’s. Methods A prospective and consecutive assessment of 103 hospitalized patients …

[Inferior vena cava malformations and deep venous thrombosis].

We carried out a prospective study of 116 patients under 50 years of age who had deep venous thrombosis of the lower extremities to determine whether the presence of congenital anomaly of the inferior vena cava (IVC) was a risk factor for the disease. All patients were investigated by Doppler echography. Some 37 patients who had iliac vein occlusion also underwent phlebography. In 10 patients in whom the IVC was difficult to image, magnetic resonance angiography or computerized axial tomography was carried out. In all patients, studies of antithrombin, protein C and protein S deficiency, factor V Leiden, prothrombin G20210A, antiphospholipid antibodies, and acquired risk factors were also p…

Telitromicina, un posible nuevo potenciador del acenocumarol

Lumbar osteomyelitis and epidural abscess complicating recurrent pilonidal cyst: report of a case.

PURPOSE: This study was conducted to report the rare presentation of lumbar osteomyelitis and epidural abscess as a complication of a pilonidal cyst. METHODS: A case report is presented. RESULTS: We describe the rare case of a male patient with diabetes with a recurring pilonidal cyst who developed a lumbar osteomyelitis and epidural abscess three weeks after pilonidal cyst excision with epidural anesthesia, with a fatal outcome despite emergency treatment. CONCLUSIONS: Life-threatening complications should be kept in mind in high-risk patients with repetitive surgery and neurologic involvement.

'Pulmonary thrombosis in situ': risk factors, clinic characteristics and long-term evolution.

: Pulmonary embolism typically occurs from deep venous thrombosis (DVT). However, not always a DVT can be identified, and 'in situ' generation of pulmonary embolism has been considered, referred to in the literature as 'De novo pulmonary embolism' (DNPE). The objective of the study is to assess risk factors, comorbidities, clinic characteristics and long-term evolution of patients with pulmonary embolism in the absence of an identified source. Retrospective study of 280 patients with pulmonary embolism, 190 pulmonary embolisms with DVT group and 90 (32%) pulmonary embolism without DVT (DNPE group), admitted to an Internal Medicine Department of a tertiary hospital from January 2012 to Decem…

Risk factors associated with retinal vein occlusion

Summary Aims Retinal vein occlusion (RVO) is the most frequent retinal vascular disease after diabetic retinopathy in which arterial risk factors are much more relevant than venous factors. The objective was to evaluate the role of risk factors in the development of the first episode of RVO. Subjects and Methods One hundred patients with RVO [mean age 56 years, 42% females and mean body mass index (BMI) 27.5 kg/m2] were recruited consecutively from the outpatient clinic of a tertiary hospital in Valencia (Spain). All subjects underwent clinical assessment including anthropometric and blood pressure measurements and laboratory test including homocysteine, antiphospholipid antibodies (aPLAs) …