Author: Qijian Ni

0000000000011895

AUTHOR

Qijian Ni

Asymmetric synthesis of cyclopentanes bearing four contiguous stereocenters via an NHC-catalyzed Michael/Michael/esterification domino reaction.

An NHC-catalyzed Michael/Michael/esterification domino reaction via homoenolate/enolate intermediates for the asymmetric synthesis of tetrasubstituted cyclopentanes is described.

research product

ChemInform Abstract: Asymmetric Synthesis of Cyclopentanes Bearing Four Contiguous Stereocenters via an NHC-Catalyzed Michael/Michael/Esterification Domino Reaction.

An NHC-catalyzed Michael/Michael/esterification domino reaction via homoenolate/enolate intermediates for the asymmetric synthesis of tetrasubstituted cyclopentanes bearing four contiguous stereocenters is described. A variety of α,β-unsaturated aldehydes and 2-nitroallylic acetates react well with good domino yields and high stereoselectivities.

research product

CCDC 1437686: Experimental Crystal Structure Determination

Related Article: Tao Shu, Qijian Ni, Xiaoxiao Song, Kun Zhao, Tianyu Wu, Rakesh Puttreddy, Kari Rissanen, Dieter Enders|2016|Chem.Commun.|52|2609|doi:10.1039/C5CC09581F

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