ChemInform Abstract: Asymmetric Synthesis of Cyclopentanes Bearing Four Contiguous Stereocenters via an NHC-Catalyzed Michael/Michael/Esterification Domino Reaction.

6533b7d9fe1ef96bd126cab5

RESEARCH PRODUCT

ChemInform Abstract: Asymmetric Synthesis of Cyclopentanes Bearing Four Contiguous Stereocenters via an NHC-Catalyzed Michael/Michael/Esterification Domino Reaction.

Kun Zhao Tao Shu Qijian Ni Tianyu Wu Dieter Enders Rakesh Puttreddy Xiaoxiao Song Kari Rissanen

subject

Cyclopentanes Bearing (mechanical)Cascade reaction law Chemistry Stereochemistry Enantioselective synthesis General Medicine Domino law.invention Catalysis Stereocenter

description

An NHC-catalyzed Michael/Michael/esterification domino reaction via homoenolate/enolate intermediates for the asymmetric synthesis of tetrasubstituted cyclopentanes bearing four contiguous stereocenters is described. A variety of α,β-unsaturated aldehydes and 2-nitroallylic acetates react well with good domino yields and high stereoselectivities.

year	journal	country	edition	language
2016-05-01	ChemInform

https://doi.org/10.1002/chin.201624067

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