0000000000011905
AUTHOR
C. Luley
Begleitende Inhaltsstoffe in 22 OTC-Fischöl- und Lebertranpräparaten: Cholesterin, Schwermetalle und Vitamin A
Fischolkapseln werden von selbstmedizierenden Patienten in zunehmendem Mase eingenommen. Hier wurde der Frage nachgegangen, ob 22 kommerziell erhaltliche Fischol- und Lebertranzubereitungen Begleitsubstanzen enthalten, deren Menge unter Umstanden nachteilig fur den Patienten sein konnten. Gemessen wurden: Cholesterin mit der Gaschromatographie, Schwermetalle mittels Atomabsorption und Vitamin A mit der hochauflosenden Flussigkeitschromatographie (HPLC). Sowohl der Cholesterin-als auch der Schwermetallgehalt lagen in unbedenklichen Bereichen. Der Vitamin-A-Gehalt von Lebertrankapseln wurde jedoch in Mengen gefunden, bei denen schwangere Frauen die Dosierungsempfehlungen der Hersteller nicht …
Hypertriglyceridemia and Omega-3 Fatty Acids
Recent studies by Bang and Dyerberg (1) have stimulated interest in the metabolism of omega-3 fatty acids and have suggested a link between the ingestion of these fatty acids in a diet and the low death rate from athersclerotic disease in Eskimos. In Japan, where fish consumption has traditionally been high, a concommitant shift in tissue lipid consumption favouring omega-3 polyunsaturated fatty acids has been interpreted as causative of a relatively low incidence of cardiovascular disease (1). When analyzing Eskimo food consumption, it became clear that the consumption of omega-3 PUFA is much higher besides a 50% reduction of saturated fat and a relatively high content of monounsaturated f…
Heterogeneous response to differentiation induction with different polar compounds in a clonal rat rhabdomyosarcoma cell line (BA-HAN-1C)
The clonal rat rhabdomyosarcoma cell line BA-HAN-1C was tested for its susceptibility to differentiation induction with different polar compounds. This cell line is composed of proliferating mononuclear tumour cells, some of which spontaneously fuse to form terminally differentiated postmitotic myotube-like giant cells. Exposure of BA-HAN-1C cells to dimethylsulphoxide (DMSO), hexamethylene bisacetamide (HMBA), sodium butyrate (NaBut) and N-monomethylformamide (NMF) resulted in a significant inhibition of proliferation (P less than 0.001) and in a simultaneous increase in differentiation. The response was most pronounced after exposure to NMF as evidenced by a marked increase in the creatin…
Fetal calf serum and retinoic acid affect proliferation and terminal differentiation of a rat rhabdomyosarcoma cell line (BA-HAN-1C)
We report on the establishment of a model for differentiation induction in sarcomas, using the clonal rhabdomyosarcoma cell line BA-HAN-1C. This rhabdomyosarcoma cell line is composed of morphologically undifferentiated mononuclear stem cells, some of which spontaneously fuse to form terminally differentiated multinuclear myotube-like giant cells. The deprivation of fetal calf serum (FCS) or the exposure to retinoic acid, respectively, resulted in a significant inhibition of proliferation (P less than 0.001) and a marked increase in cellular differentiation as shown by a significant increase in the number of myotube-like giant cells (P less than 0.001) and in the creatine kinase activity (P…