Changes of the renin-angiotensin and of the kallikrein-kinin system after administration of saline, christalloid and colloid solution in the rat. Effects of captopril.

Drug-induced variations of the renin-angiotensin-aldosterone system in rats. I. Diuretics.

Summary Groups of 10 rats were treated with diuretics (furosemide, hydrochlorotiazide, spironolactone, triamterene) under conditions of high or low plasma renin activity (PRA) brought about by administering distilled water or saline load, respectively. PRA, plasma aldosterone levels, urine aldosterone concentration as well as diuresis and Na+ and K+ excretion were

Platelet Function Changes in Acute Myocardial Infarction

Whether the thrombotic component of myocardial infarction is primary or secondary in a given patient, platelet function alterations can influence many mechanisms — operating at the microenvi-ronmental level — from which it depends if the thrombotic lesion grows or sends platelet emboli to the smaller myocardial vessels.

Drug induced variations of the renin-angiotensin-aldosterone system in rats. II. Antihypertensives

Summary Groups of male rats were treated with antihypertensive drugs (alpha-methyl-dopa, clonidine, propranolol, reserpine, diazoxide) which were administered under conditions causing the onset of high plasma renin activity (PRA) and high plasma and urine aldosterone levels, i.e. together with distilled water load (5% of body weight). Alpha-methyl-dopa and propranolol, which fail to significantly alter PRA and plasma aldosterone levels when administered without distilled water load, cause a marked decrease of plasma and urine aldosterone levels and of PRA when administered together with distilled water load, while diazoxide, and reserpine cause a marked increase of these values. Clonidine c…

Modifications induced in the renin-angiotensin-aldo-sterone system of rats by alpha-blocking drugs.

Summary The data reported in the present paper refer to quantitative variations of plasma renin activity and plasma aldosterone levels after administration of alpha-blocking agents, i.e. phentolamine, phenoxybenzamine and gihydroergotoxin derivatives, either to rats kept on a standard diet with water ad libitum or to rats receiving distilled water load, the latter treatment causing an increase of both plasma renin activity and plasma aldosterone levels if compared to control values. No strict correlation between (a) drug-induced modifications of plasma renin activity and plasma aldosterone levels and (b) blood pressure drop caused by the same drugs was shown to occur under either experiment…

Variations of plas14a benin activity and aldostehone levels in the rat after administration of saline, chrystalloid and colloid solutions

Abstract The data reported in the present paper refer to quantitative variations of plasma renin activity (PRA.) and of plasma aldosterone levels in rats after adiministration of saline, chrystalloid and colloid solutions. In our experimental conditions PRA and plasma aldosterone levels were shown to increase significantly after administration of distilled water and glucose solution. Variations of PRA and plasma aldosterone levels were only slight when plasma volume was made to increase due to administration of polyvinylpirrolidone solution. PRA, instead, was significantly lower in rats having received saline salution.