6533b82ffe1ef96bd1295127

RESEARCH PRODUCT

Drug-induced variations of the renin-angiotensin-aldosterone system in rats. I. Diuretics.

L. ValdesM. PalazzoadrianoS. LatteriV. AlbanoL. Bellanca

subject

Malemedicine.medical_specialtyDiuresisPharmacologySpironolactonePlasma renin activityExcretionchemistry.chemical_compoundInternal medicineRenin–angiotensin systemReninmedicineAnimalsDiureticsAldosteronePharmacologyTriamtereneAldosteroneAngiotensin IISodiumFurosemideDiuresisRatsEndocrinologychemistrySpironolactonePotassiummedicine.drugTriamterene

description

Summary Groups of 10 rats were treated with diuretics (furosemide, hydrochlorotiazide, spironolactone, triamterene) under conditions of high or low plasma renin activity (PRA) brought about by administering distilled water or saline load, respectively. PRA, plasma aldosterone levels, urine aldosterone concentration as well as diuresis and Na+ and K+ excretion were

yearjournalcountryeditionlanguage
1977-11-01Pharmacological research communications
10.1016/s0031-6989(77)80103-3https://pubmed.ncbi.nlm.nih.gov/605153