Measurement of the Soft-Drop Jet Mass in pp Collisions at s=13  TeV with the ATLAS Detector

2018

Jet substructure observables have significantly extended the search program for physics beyond the standard model at the Large Hadron Collider. The state-of-the-art tools have been motivated by the ...

Evidence for the decay X(3872)→ψ(2S)γ

2014

Evidence for the decay mode X(3872) -> psi(2S)gamma in B+ -> X(3872)K+ decays is found with a significance of 4.4 standard deviations. The analysis is based on a data sample of proton proton collisions, corresponding to an integrated luminosity of 3 fb(-1), collected with the LHCb detector, at centre-of-mass energies of 7 and 8 TeV. The ratio of the branching fraction of the X(3872) -> psi(2S)gamma decay to that of the X(3872) -> J/psi gamma decay is measured to be B(X(3872) -> psi(2S)gamma)/B(X(3872) -> J/psi gamma) = 2.46 +/- 0.64 +/- 0.29, where the first uncertainty is statistical and the second is systematic. The measured value does not support a pure D (D) over bar* molecular interpre…

Observations of Bs0→ψ(2S)η and B(s)0→ψ(2S)π+π− decays

2013

First observations of the $B^0_s \rightarrow \psi(2S) \eta$, $B^0 \rightarrow \psi(2S) \pi^+ \pi^-$ and $B^0_s \rightarrow \psi(2S) \pi^+ \pi^-$ decays are made using a dataset corresponding to an integrated luminosity of 1.0~$fb^{-1}$ collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of $\sqrt{s}=7$ TeV. The ratios of the branching fractions of each of the $\psi(2S)$ modes with respect to the corresponding $J/\psi$ decays are \[ \frac{\mathcal{B}(B^0_s \rightarrow \psi(2S) \eta) }{\mathcal{B}(B^0_s \rightarrow J/\psi \eta)} =0.83\pm0.14\,(stat)\pm0.12\,(syst)\pm0.02\,(\mathcalB}), \] \[ \frac{\mathcal{B}(B^0 \rightarrow \psi(2S) \pi^+ \pi^-)}{\mathcal{…

Search for the Xb and other hidden-beauty states in the π+π−ϒ(1S) channel at ATLAS

2015

This Letter presents a search for a hidden-beauty counterpart of the X(3872) in the mass ranges 10.05--10.31 GeV and 10.40--11.00 GeV, in the channel Xb→π+π−Υ(1S)(→μ+μ−), using 16.2 fb−1 of s√=8 TeV pp collision data collected by the ATLAS detector at the LHC. No evidence for new narrow states is found, and upper limits are set on the product of the Xb cross section and branching fraction, relative to those of the Υ(2S), at the 95% confidence level using the CLS approach. These limits range from 0.8% to 4.0%, depending on mass. For masses above 10.1 GeV, the expected upper limits from this analysis are the most restrictive to date. Searches for production of the Υ(13DJ), Υ(10860), and Υ(110…

Measurement of exclusive γγ→ℓ+ℓ− production in proton–proton collisions at s=7 TeV with the ATLAS detector

2015

This Letter reports a measurement of the exclusive gamma gamma -> l(+)l(-) (l = e, mu) cross-section in proton-proton collisions at a centre-of-mass energy of 7 TeV by the ATLAS experiment at the LHC, based on an integrated luminosity of 4.6 fb(-1). For the electron or muon pairs satisfying exclusive selection criteria, a fit to the dilepton acoplanarity distribution is used to extract the fiducial cross-sections. The cross-section in the electron channel is determined to be sigma(excl)(gamma gamma -> e+e-) = 0.428 +/- 0.035 (stat.) +/- 0.018 (syst.) pbfor a phase-space region with invariant mass of the electron pairs greater than 24GeV, in which both electrons have transverse momentum p(T)…

Probing the Quantum Interference between Singly and Doubly Resonant Top-Quark Production in pp Collisions at s=13  TeV with the ATLAS Detector

2018

This Letter presents a normalized differential cross-section measurement in a fiducial phase-space region where interference effects between top-quark pair production and associated production of a single top quark with a W boson and a b-quark are significant. Events with exactly two leptons (ee, μμ, or eμ) and two b-tagged jets that satisfy a multiparticle invariant mass requirement are selected from 36.1  fb^{-1} of proton-proton collision data taken at sqrt[s]=13  TeV with the ATLAS detector at the LHC in 2015 and 2016. The results are compared with predictions from simulations using various strategies for the interference. The standard prescriptions for interference modeling are signifi…

Measurements of four-lepton production in pp collisions at s=8 TeV with the ATLAS detector

2016

A search is presented for a high-mass Higgs boson in the , , , and decay modes using the ATLAS detector at the CERN Large Hadron Collider. The search uses proton-proton collision data at a centre-o ...

The ATLAS Data Acquisition and High Level Trigger system

2016

Journal of Instrumentation 11(06), P06008 (2016). doi:10.1088/1748-0221/11/06/P06008

Observation of electroweak W±Z boson pair production in association with two jets in pp collisions at s=13 TeV with the ATLAS detector

2019

An observation of electroweak W±Z production in association with two jets in proton–proton collisions is presented. The data collected by the ATLAS detector at the Large Hadron Collider in 2015 and 2016 at a centre-of-mass energy of s=13 TeV are used, corresponding to an integrated luminosity of 36.1fb−1 . Events containing three identified leptons, either electrons or muons, and two jets are selected. The electroweak production of W±Z bosons in association with two jets is measured with an observed significance of 5.3 standard deviations. A fiducial cross-section for electroweak production including interference effects and for a single leptonic decay mode is measured to be σWZjj−EW=0.57−0…

Search for high-mass dilepton resonances using 139 fb−1 of pp collision data collected at s=13 TeV with the ATLAS detector

2019

A search for high-mass dielectron and dimuon resonances in the mass range of 250 GeV to 6 TeV is presented. The data were recorded by the ATLAS experiment in proton–proton collisions at a centre-of-mass energy of s=13 TeV during Run 2 of the Large Hadron Collider and correspond to an integrated luminosity of 139 fb −1 . A functional form is fitted to the dilepton invariant-mass distribution to model the contribution from background processes, and a generic signal shape is used to determine the significance of observed deviations from this background estimate. No significant deviation is observed and upper limits are placed at the 95% confidence level on the fiducial cross-section times bran…

1035P Effect of gut microbiota on immunotherapy of advanced NSCLC

2020

Adhesion of proton beam written high aspect ratio hydrogen silsesquioxane (HSQ) nanostructures on different metallic substrates

2009

Abstract Hydrogen silsesquioxane (HSQ) behaves as a negative resist under MeV proton beam exposure. HSQ is a high-resolution resist suitable for production of tall (

Precision measurement of the ratio of the Λb0 to B¯0 lifetimes

2014

The LHCb measurement of the lifetime ratio of the Lambda(0)(b) baryon to the (B) over bar (0) meson is updated using data corresponding to an integrated luminosity of 3.0 fb(-1) collected using 7 and 8 TeV centre-of-mass energy pp collisions at the LHC. The decay modes used are Lambda(0)(b) -> J/psi pK(-) and (B) over bar (0) -> J/psi pi K-+(-), where the pi K-+(-) mass is consistent with that of the (K) over bar*(0)(892) meson. The lifetime ratio is determined with unprecedented precision to be 0.974 +/- 0.006 +/- 0.004, where the first uncertainty is statistical and the second systematic. This result is in agreement with original theoretical predictions based on the heavy quark expansion.…

Measurement of the resonant andCPcomponents inB¯0→J/ψπ+π−decays

2014

The resonant structure of the reaction (B) over bar (0) --> J/psi pi(+)pi(-) is studied using data from 3 fb(-1) of integrated luminosity collected by the LHCb experiment, one third at 7 TeV center-of-mass energy and the remainder at 8 TeV. The invariant mass of the pi(+)pi(-) pair and three decay angular distributions are used to determine the fractions of the resonant and nonresonant components. Six interfering pi(+)pi(-) states, rho(770), f(0)(500), f(2)(1270), rho(1450), omega(782) and rho(1700), are required to give a good description of invariant mass spectra and decay angular distributions. The positive and negative charge parity fractions of each of the resonant final states are det…

Feasibility and physics potential of detecting $^8$B solar neutrinos at JUNO

2021

The Jiangmen Underground Neutrino Observatory (JUNO) features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector. Some of JUNO's features make it an excellent location for 8B solar neutrino measurements, such as its low-energy threshold, high energy resolution compared with water Cherenkov detectors, and much larger target mass compared with previous liquid scintillator detectors. In this paper, we present a comprehensive assessment of JUNO's potential for detecting 8B solar neutrinos via the neutrino-electron elastic scattering process. A reduced 2 MeV threshold for the recoil electron energy is found to be achievable, assuming that the intrinsic radioactive …

Study of Beauty Hadron Decays into Pairs of Charm Hadrons

2014

First observations of the decays Λ[0 over b] → Λ[+ over c]D[− over (s)] are reported using data corresponding to an integrated luminosity of 3  fb[superscript −1] collected at 7 and 8 TeV center-of-mass energies in proton-proton collisions with the LHCb detector. In addition, the most precise measurement of the branching fraction B(B[0 over s] → D[superscript +]D[− over s]) is made and a search is performed for the decays B[0 over (s)] → Λ[+ over c]Λ[− over c]. The results obtained are B(Λ[0 over b] → Λ[+ over c]D[superscript −])/B(Λ[0 over b] → Λ[+ over c]D[− over s]) = 0.042 ± 0.003(stat) ± 0.003(syst), ⎡⎣B(Λ[0 over b] → Λ[+ over c]D[− over s]) over B([¯ over B[superscript 0] → D[superscr…

Constraints on off-shell Higgs boson production and the Higgs boson total width in ZZ → 4ℓ and ZZ → 2ℓ2ν final states with the ATLAS detector

2018

A measurement of off-shell Higgs boson production in the and decay channels, where ℓ stands for either an electron or a muon, is performed using data from proton–proton collisions at a centre-of-mass energy of TeV. The data were collected by the ATLAS experiment in 2015 and 2016 at the Large Hadron Collider, and they correspond to an integrated luminosity of . An observed (expected) upper limit on the off-shell Higgs signal strength, defined as the event yield normalised to the Standard Model prediction, of 3.8 (3.4) is obtained at 95% confidence level (CL). Assuming the ratio of the Higgs boson couplings to the Standard Model predictions is independent of the momentum transfer of the Higgs…

Precision measurement of D meson mass differences

2013

Using three- and four-body decays of D mesons produced in semileptonic b-hadron decays, precision measurements of D meson mass differences are made together with a measurement of the D-0 mass. The measurements are based on a dataset corresponding to an integrated luminosity of 1.0 fb(-1) collected in pp collisions at 7 TeV. Using the decay D-0 -> K+K-K-pi(+), the D-0 mass is measured to be M(D-0) = 1864.75 +/- 0.15 (stat) +/- 0.11 (syst) MeV/c(2). The mass differences M(D+) - M(D-0) = 4.76 +/- 0.12 (stat) +/- 0.07 (syst) MeV/c(2), M(D-s(+)) - M(D+) = 98.68 +/- 0.03 (stat) +/- 0.04 (syst) MeV/c(2) are measured using the D-0 -> K+K-pi(+)pi(-) and D-(s)(+) -> K+K-pi(+) modes.

Measurement of jet charge in dijet events froms=8  TeVppcollisions with the ATLAS detector

2016

The momentum-weighted sum of the charges of tracks associated to a jet is sensitive to the charge of the initiating quark or gluon. This paper presents a measurement of the distribution of momentum ...

Centrality, rapidity and transverse momentum dependence of J/ψ suppression in Pb–Pb collisions at sNN=2.76 TeV

2014

The inclusive J/.nuclear modification factor (R-AA) in Pb-Pb collisions at root(NN)-N-S = 2.76TeVhas been measured by ALICE as a function of centrality in the e+ e-decay channel at mid-rapidity (| y| < 0.8) and as a function of centrality, transverse momentum and rapidity in the + -decay channel at forward-rapidity (2.5 < y < 4). The J/.yields measured in Pb-Pb are suppressed compared to those in ppcollisions scaled by the number of binary collisions. The RAAintegrated over a centrality range corresponding to 90% of the inelastic Pb-Pb cross section is 0.72 - 0.06(stat.) - 0.10(syst.) at mid-rapidity and 0.58 - 0.01(stat.) - 0.09(syst.) at forward-rapidity. At low transverse momentum, signi…

Measurement of the differential cross-section of highly boosted top quarks as a function of their transverse momentum ins=8  TeVproton-proton collisi…

2016

The differential cross-section for pair production of top quarks with high transverse momentum is measured in 20.3 fb(-1) of proton-proton collisions at a center-of-mass energy of 8 TeV. The measur ...

KS0andΛProduction in Pb-Pb Collisions atsNN=2.76  TeV

2013

The ALICE measurement of K^0_S and {\Lambda} production at mid-rapidity in Pb-Pb collisions at sqrt(sNN) = 2.76 TeV is presented. The transverse momentum (pT) spectra are shown for several collision centrality intervals and in the pT range from 0.4 GeV/c (0.6 GeV/c for {\Lambda}) to 12 GeV/c. The pT dependence of the {\Lambda}/K^0_S ratios exhibits maxima in the vicinity of 3 GeV/c, and the positions of the maxima shift towards higher pT with increasing collision centrality. The magnitude of these maxima increases by almost a factor of three between most peripheral and most central Pb-Pb collisions. This baryon excess at intermediate pT is not observed in pp interactions at sqrt(s) = 0.9 Te…

Measurement of the Inelastic Proton-Proton Cross Section at s=13  TeV with the ATLAS Detector at the LHC

2016

This Letter presents a measurement of the inelastic proton-proton cross section using 60  μb^{-1} of pp collisions at a center-of-mass energy sqrt[s] of 13 TeV with the ATLAS detector at the LHC. Inelastic interactions are selected using rings of plastic scintillators in the forward region (2.07 10^{-6}, where M_{X} is the larger invariant mass of the two hadronic systems separated by the largest rapidity gap in the event. In this ξ range the scintillators are highly efficient. For diffractive events this corresponds to cases where at least one proton dissociates to a system with M_{X}>13  GeV. The measured cross section is compared with a range of theoretical predictions. When extrapolated…

Measurement of CP asymmetry in D 0 → K - K + and D 0 → π - πdecays

2014

Time-integrated $CP$ asymmetries in $D^0$ decays to the final states $K^- K^+$ and $\pi^- \pi^+$ are measured using proton-proton collisions corresponding to $3\mathrm{\,fb}^{-1}$ of integrated luminosity collected at centre-of-mass energies of $7\mathrm{\,Te\kern -0.1em V}$ and $8\mathrm{\,Te\kern -0.1em V}$. The $D^0$ mesons are produced in semileptonic $b$-hadron decays, where the charge of the accompanying muon is used to determine the initial flavour of the charm meson. The difference in $CP$ asymmetries between the two final states is measured to be \begin{align} \Delta A_{CP} = A_{CP}(K^-K^+)-A_{CP}(\pi^-\pi^+) = (+0.14 \pm 0.16\mathrm{\,(stat)} \pm 0.08\mathrm{\,(syst)})\% \ . \nonu…

Search for Resonant and Nonresonant Higgs Boson Pair Production in the bb¯τ+τ− Decay Channel in pp Collisions at s=13  TeV with the ATLAS Detector

2018

A search for resonant and nonresonant pair production of Higgs bosons in the b (b) over bar tau(+)tau(-) final state is presented. The search uses 36.1 fb(-1) of pp collision data with root s = 13 ...

Long-range angular correlations of π, K and p in p–Pb collisions at sNN=5.02 TeV

2013

Angular correlations between unidentified charged trigger particles and various species of charged associated particles (unidentified particles, pions, kaons, protons and antiprotons) are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV in the transverse-momentum range 0.3 < p(T) < 4 GeV/c. The correlations expressed as associated yield per trigger particle are obtained in the pseudorapidity range vertical bar n(lab)vertical bar < 0.8. Fourier coefficients are extracted from the long-range correlations projected onto the azimuthal angle difference and studied as a function of p(T) and in intervals of event multiplicity. In high-multipl…

Oral microbiome in Proliferative Verrucous Leukoplakia exhibits loss of diversity and enrichment of pathogens.

2021

Abstract Objectives Oral microbiome plays an important role in oral diseases. Among them, proliferative verrucous leucoplakia (PVL) is an uncommon form of progressive multifocal leukoplakia with a worryingly rate of malignant transformation. Here, we aimed to characterize the oral microbiome of PVL patients and compare it with those of healthy controls. Material and methods Oral biopsies from ten PVL patients and five healthy individuals were obtained and used to compare their microbial communities. The sequence of the V3-V4 region of 16S rRNA gene was used as the taxonomic basis to estimate and analyze the composition and diversity of bacterial populations present in the samples. Results O…

Differential branching fractions and isospin asymmetries of B -> K ((*)) μ(+) μ(-) decays

2014

The isospin asymmetries of $B \to K\mu^+\mu^-$ and $B \to K^{*}\mu^+\mu^-$ decays and the partial branching fractions of the $B^0 \to K^0\mu^+\mu^-$, $B^+ \to K^+\mu^+\mu^-$ and $B^+ \to K^{*+}\mu^+\mu^-$ decays are measured as functions of the dimuon mass squared, $q^2$. The data used correspond to an integrated luminosity of 3$~$fb$^{-1}$ from proton-proton collisions collected with the LHCb detector at centre-of-mass energies of 7$\,$TeV and 8$\,$TeV in 2011 and 2012, respectively. The isospin asymmetries are both consistent with the Standard Model expectations. The three measured branching fractions, while individually consistent, all favour lower values than their respective Standard M…

High-ET isolated-photon plus jets production in pp collisions at s=8 TeV with the ATLAS detector

2017

The dynamics of isolated-photon plus one-, two- and three-jet production in pp collisions at a centre-of-mass energy of 8 TeV are studied with the ATLAS detector at the LHC using a data set with an ...

Permanent Genetic Resources added to Molecular Ecology Resources Database 1 October 2009–30 November 2009.

2010

5 pages; International audience; This article documents the addition of 411 microsatellite marker loci and 15 pairs of Single Nucleotide Polymorphism (SNP) sequencing primers to the Molecular Ecology Resources Database. Loci were developed for the following species: Acanthopagrus schlegeli, Anopheles lesteri, Aspergillus clavatus, Aspergillus flavus, Aspergillus fumigatus, Aspergillus oryzae, Aspergillus terreus, Branchiostoma japonicum, Branchiostoma belcheri, Colias behrii, Coryphopterus personatus, Cynogolssus semilaevis, Cynoglossus semilaevis, Dendrobium officinale, Dendrobium officinale, Dysoxylum malabaricum, Metrioptera roeselii, Myrmeciza exsul, Ochotona thibetana, Neosartorya fisc…

Measurement of resonant andCPcomponents inB¯s0→J/ψπ+π−decays

2014

Structure of the decay Bs0→J/ψπ+π- is studied using data corresponding to 3fb-1 of integrated luminosity from pp collisions produced by the LHC and collected by the LHCb detector. Five interfering π+π- states are required to describe the decay: f0(980),f0(1500),f0(1790),f2(1270), and f2′(1525). An alternative model including these states and a nonresonant J/ψπ+π- component also provides a good description of the data. Based on the different transversity components measured for the spin-2 intermediate states, the final state is found to be compatible with being entirely CP odd. The CP-even part is found to be <2.3% at a 95% confidence level. The f0(500) state is not observed, allowing a limi…

Production of charged pions, kaons and protons at large transverse momenta in pp and Pb–Pb collisions at sNN=2.76 TeV

2014

Transverse momentum spectra of pi(+/-), K-+/- and p((p) over bar) up to p(T) = 20 GeV/c at mid-rapidity in pp, peripheral (60-80%) and central (0-5%) Pb-Pb collisions at v root s(NN) = 2.76 TeV have been measured using the ALICE detector at the Large Hadron Collider. The proton-to-pion and the kaon-to-pionratios both show a distinct peak at p(T) approximate to 3 GeV/c in central Pb-Pb collisions. Below the peak, p(T) 10 GeV/c particle ratios in pp and Pb-Pb collisions are in agreement and the nuclear modification factors for pi(+/-), K-+/- and p((p) over bar) indicate that, within the systematic and statistical uncertainties, the suppression is the same. This suggests that the chemical comp…

Effective lifetime measurements in theBs0→K+K−,B0→K+π−andBs0→π+K−decays

2014

Measurements of the effective lifetimes in the B-s(0) -> K+K-, B-0 -> K+pi(-) and B-s(0) -> pi K-+(-) decays are presented using 1.0 fb(-1)of pp collision data collected at a centre-of-mass energy of 7 TeV by the LHCb experiment. The analysis uses a data-driven approach to correct for the decay time acceptance. The measured effective lifetimes are tau(Bs0 -> K+K-) = 1.407 +/- 0.016 (stat) +/- 0.007 (syst) ps, tau(Bs0 -> K+pi-) = 1.524 +/- 0.011 (stat) +/- 0.004 (syst) ps, tau(Bs0 ->pi+K-) = 1.60 +/- 0.06 (stat) +/- 0.01 (syst) ps. This is the most precise determination to date of the effective lifetime in the B-s(0) -> K+K- decay and provides constraints on contributions from physics beyond…

Measurement of the correlation between the polar angles of leptons from top quark decays in the helicity basis ats=7  TeVusing the ATLAS detector

2016

A measurement of the correlations between the polar angles of leptons from the decay of pair-produced t and (t) over bar quarks in the helicity basis is reported, using proton-proton collision data collected by the ATLAS detector at the LHC. The dataset corresponds to an integrated luminosity of 4.6 fb(-1) at a center-of-mass energy of root s = 7 TeV collected during 2011. Candidate events are selected in the dilepton topology with large missing transverse momentum and at least two jets. The angles theta(1) and theta(2) between the charged leptons and the direction of motion of the parent quarks in the t (t) over bar rest frame are sensitive to the spin information, and the distribution of …

Model-independent confirmation of theZ(4430)−state

2015

The decay $B^0\to \psi(2S) K^+\pi^-$ is analyzed using $\rm 3~fb^{-1}$ of $pp$ collision data collected with the LHCb detector. A model-independent description of the $\psi(2S) \pi$ mass spectrum is obtained, using as input the $K\pi$ mass spectrum and angular distribution derived directly from data, without requiring a theoretical description of resonance shapes or their interference. The hypothesis that the $\psi(2S)\pi$ mass spectrum can be described in terms of $K\pi$ reflections alone is rejected with more than 8$\sigma$ significance. This provides confirmation, in a model-independent way, of the need for an additional resonant component in the mass region of the $Z(4430)^-$ exotic sta…

Analysis of immunosuppressive factors produced by tumorspheres in NSCLC: Prognostic value of galectin-3 in adenocarcinoma

2019

Abstract Background Cancer stem cells (CSCs) are targets poorly recognized by the immune surveillance system given that they induce an immunosuppressive microenvironment. The aim of this work is to study the interactions between CSCs and the immune microenvironment in NSCLC. Methods Tumor cells from 8 resected NSCLC patients and 12 cell lines were established as tumorspheres enriched in CSCs and as monolayers. The gene expression of IL-4, IL-10, IL6, IL8 and LGALS-3 was analyzed by RTqPCR. Results were validated at a protein level by a sensitivity bead-based multiplex immunoassay using the Millipore kit for Luminex 100/200. The prognostic value of these factors in silico was determined in a…

Correction to: Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study (Intensive Care M…

2018

The members of the LUNG SAFE Investigators and the ESICM Trials Group were provided in such a way that they could not be indexed as collaborators on PubMed. The publisher apologizes for this error.

Differential branching fraction and angular analysis of the decay $B^{0} \to K^{*0} \mu^{+}\mu^{-}$

2013

The angular distribution and differential branching fraction of the decay B-0 -> K*(0)mu(+)mu(-) are studied using a data sample, collected by the LHCb experiment in pp collisions at root s = 7 TeV, corresponding to an integrated luminosity of 1.0 fb(-1). Several angular observables are measured in bins of the dimuon invariant mass squared, q(2). A first measurement of the zero-crossing point of the forward-backward asymmetry of the dimuon system is also presented. The zero-crossing point is measured to be q(0)(2) = 4.9 +/- 0.9 GeV2/c(4), where the uncertainty is the sum of statistical and systematic uncertainties. The results are consistent with the Standard Model predictions.

Search for direct CP violation in D0→h−h+ modes using semileptonic B decays

2013

A search for direct CP violation in D0 -> h- h+ (where h=K or pi) is presented using data corresponding to an integrated luminosity of 1.0 fb^-1 collected in 2011 by LHCb in pp collisions at a centre-of-mass energy of 7 TeV. The analysis uses D0 mesons produced in inclusive semileptonic b-hadron decays to the D0 mu X final state, where the charge of the accompanying muon is used to tag the flavour of the D0 meson. The difference in the CP-violating asymmetries between the two decay channels is measured to be Delta A_CP = A_CP(K-K+) - A_CP(pi-pi+) = (0.49 +- 0.30 (stat) +- 0.14 (syst)) % . This result does not confirm the evidence for direct CP violation in the charm sector reported in other…

Lung tumorspheres as a drug screening platform against cancer stem cells.

2019

Treatment resistance and metastasis are linked to cancer stem cells (CSCs). This population represents a promising target, but remains unexplored in lung cancer. The main objective of this study was to characterize lung CSCs and discover new therapeutic strategies.

Measurements of the Λb0→J/ψΛ decay amplitudes and the Λb0 polarisation in pp collisions at s=7 TeV

2013

An angular analysis of Λ0b→J/ψΛ decays is performed using a data sample corresponding to 1.0 fb−1 collected in pp collisions at √s=7 TeV with the LHCb detector at the LHC. A parity violating asymmetry parameter characterising the Λ0b→J/ψΛ decay of 0.05±0.17±0.07 and a Λ0b transverse production polarisation of 0.06±0.07±0.02 are measured, where the first uncertainty is statistical and the second systematic.

Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study

2018

Purpose: To evaluate patients with resolved versus confirmed ARDS, identify subgroups with substantial mortality risk, and to determine the utility of day 2 ARDS reclassification. Methods: Our primary objective, in this secondary LUNG SAFE analysis, was to compare outcome in patients with resolved versus confirmed ARDS after 24 h. Secondary objectives included identifying factors associated with ARDS persistence and mortality, and the utility of day 2 ARDS reclassification. Results: Of 2377 patients fulfilling the ARDS definition on the first day of ARDS (day 1) and receiving invasive mechanical ventilation, 503 (24%) no longer fulfilled the ARDS definition the next day, 52% of whom initial…

Soluble biomarker signature to predict outcome of patients with non-small-cell lung cancer (NSCLC) treated with anti-PD1/PDL1 monoclonal antibodies.

2019

e20685 Background: Immunotherapy with anti-PD1/PDL1 monoclonal antibodies has become the second line standard treatment for most patients diagnosed of advanced Non-Small-Cell lung cancer (NSCLC). The aim of this study is to assess the utility of circulating biomarkers such as sPDL1, sPDL2, sCD137, sIDO, sTIM3, sCD28, sCD27, sCTLA4, sHVEM, sLAG3, sCD80 and sGITR for predicting efficacy of immunotherapy with anti-PD1/PDL1 therapies. Methods: Blood samples were collected before treatment from 50 NSCLC patients who received anti PD1/PDL1 therapies (second line). Plasma biomarkers´ levels were measured by Multiplex bead-based assays. Continuous variables were categorized using the median as a c…

A first search for coincident gravitational waves and high energy neutrinos using LIGO, Virgo and ANTARES data from 2007

2013

A search for high-energy neutrinos coming from the direction of the Sun has been performed using the data recorded by the ANTARES neutrino telescope during 2007 and 2008. The neutrino selection criteria have been chosen to maximize the selection of possible signals produced by the self-annihilation of weakly interacting massive particles accumulated in the centre of the Sun with respect to the atmospheric background. After data unblinding, the number of neutrinos observed towards the Sun was found to be compatible with background expectations. The 90% CL upper limits in terms of spin-dependent and spin-independent WIMP-proton cross-sections are derived and compared to predictions of two sup…

Combination of Searches for Invisible Higgs Boson Decays with the ATLAS Experiment

2019

Dark matter particles, if sufficiently light, may be produced in decays of the Higgs boson. This Letter presents a statistical combination of searches for H → invisible decays where H is produced according to the standard model via vector boson fusion, Z(ℓℓ)H, and W/Z(had)H, all performed with the ATLAS detector using 36.1  fb⁻¹ of pp collisions at a center-of-mass energy of √s = 13  TeV at the LHC. In combination with the results at √s = 7 and 8 TeV, an exclusion limit on the H → invisible branching ratio of 0.26(0.17-0.05+0.07) at 95% confidence level is observed (expected).

Interactions of cancer stem cell and immune microenvironment in non-small cell lung cancer (NSCLC)

2018

Search for invisible Higgs boson decays in vector boson fusion at s=13TeV with the ATLAS detector

2019

We report a search for Higgs bosons that are produced via vector boson fusion and subsequently decay into invisible particles. The experimental signature is an energetic jet pair with invariant mass of O(1)TeV and O(100)GeV missing transverse momentum. The analysis uses 36.1 fb −1 of pp collision data at s=13TeV recorded by the ATLAS detector at the LHC. In the signal region the 2252 observed events are consistent with the background estimation. Assuming a 125GeV scalar particle with Standard Model cross sections, the upper limit on the branching fraction of the Higgs boson decay into invisible particles is 0.37 at 95% confidence level where 0.28 was expected. This limit is interpreted in H…

Search for resonant WZ production in the fully leptonic final state in proton–proton collisions at s=13TeV with the ATLAS detector

2018

A search for a heavy resonance decaying into WZ in the fully leptonic channel (electrons and muons) is performed. It is based on proton–proton collision data collected by the ATLAS experiment at the Large Hadron Collider at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 36.1 fb −1 . No significant excess is observed over the Standard Model predictions and limits are set on the production cross section times branching ratio of a heavy vector particle produced either in quark–antiquark fusion or through vector-boson fusion. Constraints are also obtained on the mass and couplings of a singly charged Higgs boson, in the Georgi–Machacek model, produced through ve…

Analysis of gut microbiota in advanced non-small cell lung cancer (NSCLC) patients treated with immune-checkpoints blockers

2019

Abstract Background The microbiota community is considered as an organ of the human body. Recent studies have found that dysbiosis may have an impact on the interaction between immune regulation and tumor treatment. The main objective of this study is to characterize the gut microbiota in patients with non-small cell lung cancer (NSCLC) in advanced stages, and its relationship with obesity, smoking habits, clinical pathological features and response to treatment with immune-checkpoints blockers (ICB). Methods 16S rRNA gene sequencing was performed on 48 stool samples from advanced NSCLC patients prior to treatment with ICB (PD-1 inhibitor and PD-L1 inhibitor). The database used for the taxo…

Observation of Photon Polarization in theb→sγTransition

2014

This Letter presents a study of the flavor-changing neutral current radiative $B^{\pm} \to K^{\pm}\pi^{\mp}\pi^{\pm}\gamma$ decays performed using data collected in proton-proton collisions with the LHCb detector at $7$ and $8\,$TeV center-of-mass energies. In this sample, corresponding to an integrated luminosity of $3\,\text{fb}^{-1}$, nearly $14\,000$ signal events are reconstructed and selected, containing all possible intermediate resonances with a $K^{\pm}\pi^{\mp}\pi^{\pm}$ final state in the $[1.1, 1.9]\,$GeV/$c^{2}$ mass range. The distribution of the angle of the photon direction with respect to the plane defined by the final-state hadrons in their rest frame is studied in interva…

Searches for violation of lepton flavour and baryon number in tau lepton decays at LHCb

2013

Searches for the lepton flavour violating decay tau(-) -> mu(-)mu(+)mu(-) and the lepton flavour and baryon number violating decays tau(-) -> (p) over bar mu(+)mu(-) and tau(-) -> p mu(-)mu(-) have been carried out using proton-proton collision data, corresponding to an integrated luminosity of 1.0 fb(-1), taken by the LHCb experiment at root s = 7 TeV. No evidence has been found for any signal, and limits have been set at 90% confidence level on the branching fractions: B(tau(-) -> mu(-)mu(+)mu(-) mu(+)mu(-)) p mu(-)mu(-)) (p) over bar mu(+)mu(-) and tau(-) -> p mu(-)mu(-) decay modes represent the first direct experimental limits on these channels.

The DArk Matter Particle Explorer mission

2017

The DArk Matter Particle Explorer (DAMPE), one of the four scientific space science missions within the framework of the Strategic Pioneer Program on Space Science of the Chinese Academy of Sciences, is a general purpose high energy cosmic-ray and gamma-ray observatory, which was successfully launched on December 17th, 2015 from the Jiuquan Satellite Launch Center. The DAMPE scientific objectives include the study of galactic cosmic rays up to $\sim 10$ TeV and hundreds of TeV for electrons/gammas and nuclei respectively, and the search for dark matter signatures in their spectra. In this paper we illustrate the layout of the DAMPE instrument, and discuss the results of beam tests and calib…

Analysis of the Gut Microbiota: An Emerging Source of Biomarkers for Immune Checkpoint Blockade Therapy in Non-Small Cell Lung Cancer

2021

Simple Summary The immune checkpoint blockade (ICB), and concretely the blockade of the PD1/PDL1 axis, has opened up a new standard of treatment for non-small cell lung cancer (NSCLC). However, despite substantial advances in clinical care, many patients still remain refractory to these therapies. Biomarkers such as PD-L1 expression and tumor mutational burden have been associated with ICB efficacy, but the mechanisms underlying variable responses are not yet fully understood. Recently, the differential composition of the gut microbiota was studied as one of the variables accounting for interpatient heterogeneity in ICB responses. To better understand the potential role of the gut microbiot…

Measurement of photon?jet transverse momentum correlations in 5.02 TeV Pb + Pb and pp collisions with ATLAS

2019

Jets created in association with a photon can be used as a calibrated probe to study energy loss in the medium created in nuclear collisions. Measurements of the transverse momentum balance between isolated photons and inclusive jets are presented using integrated luminosities of 0.49 nb−1 of Pb + Pb collision data at TeV and 25 pb−1 of pp collision data at TeV recorded with the ATLAS detector at the LHC. Photons with transverse momentum GeV and are paired with all jets in the event that have GeV and pseudorapidity . The transverse momentum balance given by the jet-to-photon ratio, , is measured for pairs with azimuthal opening angle . Distributions of the per-photon jet yield as a function…

Search for dark matter in events with heavy quarks and missing transverse momentum in [Formula: see text] collisions with the ATLAS detector.

2014

This article reports on a search for dark matter pair production in association with bottom or top quarks in \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$20.3 \mathrm {~fb}^{-1}$$\end{document}20.3fb-1 of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$pp$$\end{document}pp collisions collected at \documentclass[12pt]{minimal} \use…

Measurement of D⁎±, D± and Ds± meson production cross sections in pp collisions at s=7 TeV with the ATLAS detector

2016

The production of D*(+/-), D-+/- and D-S(+/-) charmed mesons has been measured with the ATLAS detector in pp collisions at,/7s = 7 TeV at the LHC, using data corresponding to an integrated luminosi ...

Observation of Higgs boson production in association with a top quark pair at the LHC with the ATLAS detector

2018

Physics letters / B 784, 173 - 191 (2018). doi:10.1016/j.physletb.2018.07.035

1063P Profiling of peripheral T cell receptor beta chain repertoire in non-small cell lung cancer (NSCLC) patients treated with anti-PD1

2020

Proton beam written hydrogen silsesquioxane (HSQ) nanostructures for Nickel electroplating

2009

Abstract Hydrogen silsesquioxane (HSQ) behaves as a negative resist under MeV proton beam exposure. HSQ is a high-resolution resist suitable for production of tall ( 1.5 μ m ) high-aspect-ratio nanostructures with dimensions down to 22 nm. High-aspect-ratio HSQ structures are required in many applications, e.g. nanofluidics, biomedical research, etc. Since P-beam writing is a direct and hence slow process, it is beneficiary to fabricate a reverse image of the patterns in a metallic stamp, e.g. by Ni electroplating. The Ni stamp can then be used to produce multiple copies of the same pattern. In this study we investigate the possibility to produce Ni stamps from p-beam written HSQ samples. H…

Determination of the $X(3872)$ meson quantum numbers

2013

The quantum numbers of the X(3872) meson are determined to be J(PC) = 1(++) based on angular correlations in B+ -> X(3872)K+ decays, where X(3872) -> pi(+) pi(-) j/psi and J/psi -> pi(+) mu(-). The data correspond to 1.0 fb(-1) of pp collisions collected by the LHCb detector. The only alternative assignment allowed by previous measurements J(PC) = 2(-+) is rejected with a confidence level equivalent to more than 8 Gaussian standard deviations using a likelihood-ratio test in the full angular phase space. This result favors exotic explanations of the X(3872) state.

Performance of $b$-Jet Identification in the ATLAS Experiment

2016

We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT an…

Observation of the Resonant Character of theZ(4430)−State

2014

Resonant structures in B-0 -> psi'pi K--(+) decays are analyzed by performing a four-dimensional fit of the decay amplitude, using pp collision data corresponding to 3 fb(-1) collected with the LHCb detector. The data cannot be described with K+pi(-) resonances alone, which is confirmed with a model-independent approach. A highly significant Z(4430)(-) -> psi'pi(-) component is required, thus confirming the existence of this state. The observed evolution of the Z(4430)(-) amplitude with the psi'pi(-) mass establishes the resonant nature of this particle. The mass and width measurements are substantially improved. The spin parity is determined unambiguously to be 1(+).

Observation of the suppressed ADS modes B±→[π±K∓π+π−]DK± and B±→[π±K∓π+π−]Dπ±

2013

An analysis of and B-+/- -> DK +/- and B-+/- -> D pi(+/-) decays is presented where the D meson is reconstructed in the four-body final state K-+/-pi(-/+)pi(+)pi(-). Using LHCb data corresponding to an integrated luminosity of 1.0 fb(-1), first observations are made of the suppressed ADS modes B-+/- ->[pi K-+/-(-/+)pi(+)pi(-)](D)K-+/- and B +/- -> [pi K-+/-(-/+)pi(+)pi(-)](D)pi(+/-) with a significance of 5.1 sigma and greater than 10 sigma, respectively. Measurements of CP asymmetries and CP-conserving ratios of partial widths from this family of decays are also performed. The magnitude of the ratio between the suppressed and favoured B-+/- -> DK +/- amplitudes is determined to be r(B)(K) …

Energy dependence of the transverse momentum distributions of charged particles in pp collisions measured by ALICE

2013

Differential cross sections of charged particles in inelastic pp collisions as a function of $p_{\rm T}$ have been measured at $\sqrt{s}=$ 0.9, 2.76 and 7 TeV at the LHC. The $p_{\rm T}$ spectra are compared to NLO-pQCD calculations. Though the differential cross section for an individual $\sqrt{s}$ cannot be described by NLO-pQCD, the relative increase of cross section with $\sqrt{s}$ is in agreement with NLO-pQCD. Based on these measurements and observations, procedures are discussed to construct pp reference spectra at $\sqrt{s} =$ 2.76 and 5.02 TeV up to $p_{\rm T}$ = 50 GeV/$c$ as required for the calculation of the nuclear modification factor in nucleus-nucleus and proton-nucleus coll…

Measurement of visible cross sections in proton-lead collisions at √sNN= 5.02 TeV in van der Meer scans with the ALICE detector

2014

In 2013, the Large Hadron Collider provided proton-lead and lead-proton collisions at the center-of-mass energy per nucleon pair $\sqrt{s_{\rm{NN}}}=5.02$ TeV. Van der Meer scans were performed for both configurations of colliding beams, and the cross section was measured for two reference processes, based on particle detection by the T0 and V0 detectors, with pseudo-rapidity coverage $4.6<\eta< 4.9$, $-3.3<\eta<-3.0$ and $2.8<\eta< 5.1$, $-3.7<\eta<-1.7$, respectively. Given the asymmetric detector acceptance, the cross section was measured separately for the two configurations. The measured visible cross sections are used to calculate the integrated luminosity of the proton-lead and lead-…

Transverse momentum, rapidity, and centrality dependence of inclusive charged-particle production in sNN=5.02 TeV p+ Pb collisions measured by the AT…

2016

Measurements of the per-event charged-particle yield as a function of the charged-particle transverse momentum and rapidity are performed using p+Pbp+Pb collision data collected by the ATLAS experiment at the LHC at a centre-of-mass energy of sqrt (SNN) = 5.01 TeV. Charged particles are reconstructed over pseudorapidity |η|<2.3|η|<2.3 and transverse momentum between 0.1 GeV0.1 GeV and 22 GeV22 GeV in a dataset corresponding to an integrated luminosity of 1 μb−11 μb−1. The results are presented in the form of charged-particle nuclear modification factors, where the p+Pbp+Pb charged-particle multiplicities are compared between central and peripheral p+Pbp+Pb collisions as well as to charged-p…

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.201…

2016

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Measurement of the effective Bs0→K+K− lifetime

2012

A precise determination of the effective $B_s^0 \rightarrow K^+ K^-$ lifetime can be used to constrain contributions from physics beyond the Standard Model in the $B_s^0$ meson system. Conventional approaches select $B$ meson decay products that are significantly displaced from the $B$ meson production vertex. As a consequence, $B$ mesons with low decay times are suppressed, introducing a bias to the decay time spectrum which must be corrected. This analysis uses a technique that explicitly avoids a lifetime bias by using a neural network based trigger and event selection. Using 1.0 fb$^{-1}$ of data recorded by the LHCb experiment, the effective $B_s^0 \rightarrow K^+ K^-$ lifetime is meas…