0000000000025144
AUTHOR
Sebastian Wolf
showing 17 related works from this author
N-Heterocyclic carbenes from ylides of indolyl-imidazolium, azaindolyl-imidazolium, and indolyl-triazolium salts, and their borane adducts
2014
Abstract Indol-2-yl-imidazolium salts were deprotonated at N1 of the indole ring to give ylides. Their tautomeric N-heterocyclic carbenes (NHCs) were trapped by sulfur to give imidazole-2-thiones. Treatment of the ylides with triethylborane resulted in the formation of zwitterionic borane adducts. An analogous sequence of reactions was performed with 8-azaindol-2-yl-imidazolium salts, which served as precursor to prepare first representatives of a new heterocyclic ring system on reaction of their NHC-tautomers with triethylborane. Similarly, an indol-2-yl-1,2,4-triazolium salt was examined with respect to ylide–NHC tautomerism and trapping reactions. A nucleophilic ring transformation of in…
Macular edema: Miscellaneous.
2010
International audience; Abstract. This article provides the reader with practical information to be applied to the various remaining causes of macular edema. Some macular edemas linked to ocular diseases like radiotherapy after ocular melanomas remained of poor functional prognosis due to the primary disease. On the contrary, macular edemas occurring after retinal detachment or after some systemic or local treatment use are often temporary. Macular edema associated with epiretinal membranes or vitreomacular traction is the main cause of poor functional recovery. However, the delay to observe a significant improvement of vision after surgery should be long, as usually observed in tractional …
Accumulation of positrons from a LINAC based source
2020
International audience; The GBAR experiment aims to measure the gravitational acceleration of antihydrogen H̅. It will use H̅+ ions formed by the interaction of antiprotons with a dense positronium cloud, which will require about 1010 positrons to produce one H̅+. We present the first results on the positron accumulation, reaching 3.8±0.4×108 e+ collected in 560 s.
Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 count…
2022
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index to support local elective surgical system strengthening and address growing backlogs. Methods: First, we performed an international consultation through a four-stage consensus process to develop a multidomain index for hospital-level assess…
Efficient and robust photo-ionization loading of beryllium ions
2017
We demonstrate the efficient generation of Be$^+$ ions with a 60 ns and 150 nJ laser pulse near 235 nm for two-step photo-ionization, proven by subsequent counting the number of ions loaded into a linear Paul trap. The bandwidth and power of the laser pulse are chosen in such a way that a first, resonant step fully saturates the entire velocity distribution of beryllium atoms effusing from a thermal oven. The second excitation step is driven by the same light field causing efficient non-resonant ionization. Our ion-loading scheme is more than 15 times more efficient as compared to former pathways using two-photon continuous wave laser excitation.
Light of Two Atoms in Free Space: Bunching or Antibunching?
2020
Photon statistics divides light sources into three different categories, characterized by bunched, antibunched, or uncorrelated photon arrival times. Single atoms, ions, molecules, or solid state emitters display antibunching of photons, while classical thermal sources exhibit photon bunching. Here we demonstrate a light source in free space, where the photon statistics depends on the direction of observation, undergoing a continuous crossover between photon bunching and antibunching. We employ two trapped ions, observe their fluorescence under continuous laser light excitation, and record spatially resolved the autocorrelation function ${g}^{(2)}(\ensuremath{\tau})$ with a movable Hanbury …
Visibility of Young's interference fringes: Scattered light from small ion crystals
2015
We observe interference in the light scattered from trapped $^{40}$Ca$^+$ ion crystals. By varying the intensity of the excitation laser, we study the influence of elastic and inelastic scattering on the visibility of the fringe pattern and discriminate its effect from that of the ion temperature and wave-packet localization. In this way we determine the complex degree of coherence and the mutual coherence of light fields produced by individual atoms. We obtain interference fringes from crystals consisting of two, three and four ions in a harmonic trap. Control of the trapping potential allows for the adjustment of the interatomic distances and thus the formation of linear arrays of atoms s…
Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study
2021
We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26…
Transmission Microscopy with Nanometer Resolution Using a Deterministic Single Ion Source.
2015
We realize a single particle microscope by using deterministically extracted laser-cooled ^{40}Ca^{+} ions from a Paul trap as probe particles for transmission imaging. We demonstrate focusing of the ions to a spot size of 5.8±1.0 nm and a minimum two-sample deviation of the beam position of 1.5 nm in the focal plane. The deterministic source, even when used in combination with an imperfect detector, gives rise to a fivefold increase in the signal-to-noise ratio as compared with conventional Poissonian sources. Gating of the detector signal by the extraction event suppresses dark counts by 6 orders of magnitude. We implement a Bayes experimental design approach to microscopy in order to ma…
DR Tauri: Temporal variability of the brightness distribution in the potential planet-forming region
2015
We investigate the variability of the brightness distribution and the changing density structure of the protoplanetary disk around DR Tau, a classical T Tauri star. DR Tau is known for its peculiar variations from the ultraviolet (UV) to the mid-infrared (MIR). Our goal is to constrain the temporal variation of the disk structure based on photometric and MIR interferometric data. We observed DR Tau with the MID-infrared Interferometric instrument (MIDI) at the Very Large Telescope Interferometer (VLTI) at three epochs separated by about nine years, two months, respectively. We fit the spectral energy distribution and the MIR visibilities with radiative transfer simulations. We are able to r…
Development of a PbWO 4 detector for single-shot positron annihilation lifetime spectroscopy at the GBAR experiment
2020
International audience; We have developed a PbWO 4 (PWO) detector with a large dynamic range to measure the intensity of a positron beam and the absolute density of the ortho-positronium (o-Ps) cloud it creates. A simulation study shows that a setup based on such detectors may be used to determine the angular distribution of the emission and reflection of o-Ps to reduce part of the uncertainties of the measurement. These will allow to improve the precision in the measurement of the cross section for the (anti) hydrogen formation by (anti) proton-positronium charge exchange and to optimize the yield of antihydrogen ion which is an essential parameter in the GBAR experiment.
Evolving European guidance on the medical management of neovascular age related macular degeneration
2006
BACKGROUND: Until recently, only two options were available for the treatment of choroidal neovascularisation (CNV) associated with age related macular degeneration (AMD)-thermal laser photocoagulation and photodynamic therapy with verteporfin (PDT-V). However, new treatments for CNV are in development, and data from phase III clinical trials of some of these pharmacological interventions are now available. In light of these new data, expert guidance is required to enable retina specialists with expertise in the management of AMD to select and use the most appropriate therapies for the treatment of neovascular AMD. METHODS: Consensus from a round table of European retina specialists was obt…
Imaging Trapped Ion Structures via Fluorescence Cross-Correlation Detection
2021
Cross-correlation signals are recorded from fluorescence photons scattered in free space off a trapped ion structure. The analysis of the signal allows for unambiguously revealing the spatial frequency, thus the distance, as well as the spatial alignment of the ions. For the case of two ions we obtain from the cross-correlations a spatial frequency ${f}_{\text{spatial}}=1490\ifmmode\pm\else\textpm\fi{}{2}_{\mathrm{stat}}\ifmmode\pm\else\textpm\fi{}{8}_{\mathrm{syst}}\text{ }\text{ }{\mathrm{rad}}^{\ensuremath{-}1}$, where the statistical uncertainty improves with the integrated number of correlation events as ${N}^{\ensuremath{-}0.51\ifmmode\pm\else\textpm\fi{}0.06}$. We independently deter…
Preparing single ultra-cold antihydrogen atoms for free-fall in GBAR
2014
We discuss an experimental approach allowing to prepare antihydrogen atoms for the GBAR experiment. We study the feasibility of all necessary experimental steps: The capture of incoming $\bar{\rm H}^{+}$ ions at keV energies in a deep linear RF trap, sympathetic cooling by laser cooled Be+ ions, transfer to a miniaturized trap and Raman sideband cooling of an ion pair to the motional ground state, and further reducing the momentum of the wavepacket by adiabatic opening of the trap. For each step, we point out the experimental challenges and discuss the efficiency and characteristic times, showing that capture and cooling are possible within a few seconds. We discuss an experimental approach…
Optical super-resolution sensing of a trapped ion's wave packet size
2021
We demonstrate super-resolution optical sensing of the size of the wave packet of a single trapped ion. Our method extends the well known ground state depletion (GSD) technique to the coherent regime. Here, we use a hollow beam to strongly saturate a coherently driven dipole-forbidden transition around a sub-diffraction limited area at its center and observe state dependent fluorescence. By spatially scanning this laser beam over a single trapped $^{40}\mathrm{Ca}^+$ ion, we are able to measure the wave packet sizes of cooled ions. Using a depletion beam waist of $4.2(1)\,\mu$m we reach a spatial resolution which allows us to determine a wave packet size of $39(9)\,$nm for a near ground sta…
SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study
2021
SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 da…
CCDC 1018185: Experimental Crystal Structure Determination
2015
Related Article: Nazar Pidlypnyi, Sebastian Wolf, Ming Liu, Kari Rissanen, Martin Nieger, Andreas Schmidt|2014|Tetrahedron|70|8672|doi:10.1016/j.tet.2014.09.035