0000000000026090
AUTHOR
R. W. Greene
Electrophysiological Analysis of Effects of Exogenous and Endogenous Adenosine in Hippocampal Slices
Little doubt remains that adenosine serves a modulatory role in the nervous system (Sattin and Rail, 1970; Shimizu and Daly, 1970; Fredholm and Hedqvist, 1980; Phillis and Wu, 1981; Stone, 1981; Daly et al., 1984; Dunwiddie, 1985). While electrophysiologically active concentrations of adenosine have been found in the extracellular fluid, the source and control of the levels of this active adenosine are unclear. There are indications that adenosine is released (or coreleased) from synaptic endings, fulfilling a typical transmitter role (Burnstock, 1975, 1981; Nagy et al., 1986). A synaptic hyperpolarization in autonomic neurons has been identified as an adenosine-mediated potential (Akasu et…
Long-Term Potentiation in Slices from Human Hippocampus
Long-term potentiation (LTP) has been observed in slices from human hippocampi removed for intractable epilepsy using extra- and intracellular recording in vitro. Furthermore the effects of several neuroactive substances with possible relevance for synaptic plasticity was investigated. Human hippocampal neurones in vitro display properties very similar to the respective rodent cells.