0000000000034420
AUTHOR
A. Schröder
The beta-decay of95Rb and97Rb
Theβ-decay of 377 ms95Rb and 168ms97Rb has been thoroughly investigated by means ofγ-ray, conversion electron andβ-delayed neutron spectroscopy. More than 97% of theβ-decay to particle-bound states has been placed in level schemes of95Sr and97Sr. High-resolution neutron spectroscopic studies have allowed to extend the knowledge of the excitation spectra up to 9 MeV, respectively 10 MeV. The density of neutron-unbound levels in95Sr and97Sr has been derived from peak stripping analyses of the neutron spectra. Beta-strength functions (S β(E)) have been investigated in detail. They indicate that Gamow-Tellerβ-decay of both precursors is dominated by nuclear structure. The discovered pronounced …
Overlappingβdecay and resonance neutron spectroscopy of levels inKr87
Energy levels in $^{87}\mathrm{Kr}$ have been studied, with special emphasis on the unbound region, using two different methods. The first method comprises neutron capture and transmission measurements on an enriched gas target of $^{86}\mathrm{Kr}$ using neutron time-of-flight techniques. In this way, neutron widths were determined for 39 resonances below 400 keV and capture areas for 14 resonances below 90 keV. The second method is a decay study of 56-s $^{87}\mathrm{Br}$ in which a level scheme for $^{87}\mathrm{Kr}$ has been established that shows 126 levels in the bound and 12 levels in the unbound region. A detailed comparison amongst the neutron resonance, the $\ensuremath{\gamma}$-r…
Akute Gefäßverschlüsse — interdisziplinäres Therapiespektrum
Unter dem speziellen Gesichtspunkt der Verbesserung der Behandlungsergebnisse des akuten Ischamie-Syndroms der unteren Extremitaten erfolgte eine retrospektive Analyse von 344 Patienten. Eine arterielle Embolie lag in 46,4%, eine akute Thrombose in 32,7%, den akuten Verschlussen zugrunde. In 20,9% war eine eindeutige Zuordnung der Verschlusursache nicht moglich. Das Zeitintervall zwischen Symptom und Beginn der Therapie betrug bei den Embolien in 29% und bei den Thrombosen in 41% mehr als zwolf Stunden. In 67% wurde eine transfemorale indirekte Thrombembolektomie durchgefuhrt. Durch den Einsatz neuerer risikoarmer Behandlungsmethoden (Aspirationsembolektomie, Lyse und PTA etc.) last sich da…
Abstract B072: Phase Ib trial of the RNActive cancer vaccine BI 1361849 (CV9202) and local radiotherapy in patients with stage IV non-small cell lung cancer (NSCLC) with disease control after first-line chemotherapy or during therapy with an epidermal growth factor receptor tyrosine kinase inhibitor: Updated clinical results and immune responses
Abstract Background: Preclinical studies demonstrated that local radiotherapy (RT) acts synergistically with RNActive mRNA vaccines to enhance anti-tumor effects and increase tumor-infiltrating lymphocytes. BI 1361849 is a therapeutic vaccine comprising optimized mRNA constituents encoding six NSCLC-associated antigens. Interim data of a phase Ib study, employing local RT to increase the immune mediated tumor control by BI 1361849, have been previously published (J Clin Oncol 34, 2016, suppl; abstr e20627). Here we report results of immune response analyses as well as updated safety and efficacy data. Methods: Patients (pts) with stage IV NSCLC were enrolled in three cohorts based on histol…
Beta-delayed neutron emission from93?100Rb to excited states in the residual Sr isotopes
Beta-delayed neutron emission from the precursors93–100Rb to excited states in the residual nuclei92–99Sr has been measured by means ofγ-ray and neutron spectroscopy. In general, considerable neutron feeding of excited final states is observed. The experimental branching ratios (P ) are compared to predictions from statistical model calculations. It is demonstrated that the main parameter affecting theP -values is the shape of theβ-strength function (S β). For several Rb isotopes hindrance, respectively enhancement of neutron branches to specific final states is observed giving evidence for the persistence of intermediate structure of the neutron-emitting states. By the example of98Rb it is…
Resource utilization and productivity loss in persons with spina bifida—an observational study of patients in a tertiary urology clinic in Germany.
Background and purpose To investigate resource use and burden associated with spina bifida (SB) in Germany. Methods A questionnaire was used to obtain information on SB-related healthcare resource use and assistive technologies used for the last 1 and 10 years. Individuals with SB were recruited at a tertiary specialist clinic. To participate, persons with SB required the cognitive ability to respond or a caregiver to answer questions on their behalf. They could use personal medical charts or other records to answer. The analyses included assessment of frequency and extent of resource use for both time frames. Results Data on 88 persons with a diagnosis of SB were collected (44% female). Du…
Beta-delayed neutrons and high-energy gamma-rays from decay of137I
Beta-delayed neutrons and high-energyγ-rays following decay of137I have been studied in order to characterizeβ-decay to and deexcitation of neutron-unbound levels in137Xe. The totalγ-ray intensity observed accounts for at least 20% of theβ-intensity to levels aboveB n . No evidence was found for neutron andγ-ray emission from the same levels. With the experimentalβ-strength function aboveB n detailed tests were performed on the reproduction of the experimental neutron spectrum, the level density and Porter-Thomas fluctuations of the reducedβ-transition probabilities to highly excited states in137Xe.
Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress.
A disintegrin and metalloprotease (ADAM) 10 is the main candidate enzyme for the alpha-secretase processing of the amyloid precursor protein (APP). Neuron-specific ADAM10 overexpression proved beneficial in the APP[V717I] mutant Alzheimer mouse model [Postina R, Schroeder A, Dewachter I, Bohl J, Schmitt U, Kojro E, Prinzen C, Endres K, Hiemke C, Blessing M, Flamez P, Dequenne A, Godaux E, van Leuven F, Fahrenholz F (2004) A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. J Clin Invest 113:1456-1464]. Since Alzheimer patients have a high prevalence for epileptic seizures, we investigated the effects of ADAM10 modula…
Observation of beta-delayed neutron decay to excited 0+ states in the residual nucleus: The case
Abstract Beta-delayed neutron emission from 97 Rb to excited 0 + states in 96 Sr has been observed. The experimental branching ratios ( P n i ) are compared to predictions from a statistical model. It is demonstrated that, considering the influence of the strength of β -decay preceding neutron emission, the ( P n i ) reflect the different structure of the two excited 0 + states, in agreement with conclusions drawn from the measurement of their lifetimes.