0000000000039727
AUTHOR
Raúl Mínguez Blasco
Selective targeting of collagen IV in the cancer cell microenvironment reduces tumor burden
Goodpasture antigen-binding protein (GPBP) is an exportable1 Ser/Thr kinase that induces collagen IV expansion and has been associated with chemoresistance following epithelial-to-mesenchymal transition (EMT). Here we demonstrate that cancer EMT phenotypes secrete GPBP (mesenchymal GPBP) which displays a predominant multimeric oligomerization and directs the formation of previously unrecognized mesh collagen IV networks (mesenchymal collagen IV). Yeast two-hybrid (YTH) system was used to identify a 260SHCIE264 motif critical for multimeric GPBP assembly which then facilitated design of a series of potential peptidomimetics. The compound 3-[4''-methoxy-3,2'-dimethyl-(1,1';4',1'')terphenyl-2'…
La paradoja católica ante la modernidad : modelos de feminidad y mujeres católicas en España (1851-1874)
La participación del catolicismo en la conformación de las feminidades decimonónicas en España constituye el tema principal de esta tesis doctoral. Con las herramientas metodológicas procedentes de la historia del género y de la historia discursiva, la hipótesis de partida es que la feminización del discurso católico no sólo fue un factor decisivo en la construcción de la diferencia sexual durante el siglo XIX sino que también contribuyó a situar al catolicismo en esa encrucijada de caminos diversos que fue la modernidad. Los dos resultados más destacados y longevos de este proceso fueron la vinculación naturalizada de mujeres y religión y la feminización simbólica de la Iglesia católica, q…
Goodpasture Antigen-binding Protein (GPBP) Directs Myofibril Formation
Goodpasture antigen-binding protein-1 (GPBP-1) is an exportable non-conventional Ser/Thr kinase that regulates glomerular basement membrane collagen organization. Here we provide evidence that GPBP-1 accumulates in the cytoplasm of differentiating mouse myoblasts prior to myosin synthesis. Myoblasts deficient in GPBP-1 display defective myofibril formation, whereas myofibrils assemble with enhanced efficiency in those overexpressing GPBP-1. We also show that GPBP-1 targets the previously unidentified GIP130 (GPBP-interacting protein of 130 kDa), which binds to myosin and promotes its myofibrillar assembly. This report reveals that GPBP-1 directs myofibril formation, an observation that expa…
Solution versus Fluorous versus Solid-Phase Synthesis of 2,5-Disubstituted 1,3-Azoles. Preliminary Antibacterial Activity Studies
A small library of compounds with an oxa(thia)zole scaffold and structural diversity in both positions 2 and 5 has been synthesized. Double acylation of a protected glycine affords intermediate α-amido-β-ketoesters, which in turn can be dehydrated to afford 1,3-oxazoles or reacted with Lawesson’s reagent to furnish 1,3-thiazoles. This procedure was designed with its adaptation to fluorous techniques in mind. Thus, when a protected glycine with a fluorous tag in the ester moiety is used as a starting material, the synthesis can be easily completed without column chromatography purification of intermediate compounds with good to excellent yields, thus affording a suitable entry to the prepara…
Culturas políticas en la contemporaneidad. Discursos y prácticas desde los márgenes a las élites
Este libro recoge las aportaciones de los investigadores presentadas al IV Encuentro de Jovenes Investigadores en Historia Contemporanea que tuvo lugar en Valencia en septiembre de 2013.
Identification of the Iodination and Bromination Products of 3-Hydroxybenzaldehyde: Preparation of 5-Hydroxy-2-iodobenzaldehyde
The monohalogenation products of 3-hydroxybenzaldehyde (1) are useful synthons for the preparation of more complex molecules.1–4 For example, the introduction of a halogen allows the use of a Suzuk...
ChemInform Abstract: Solution versus Fluorous versus Solid-Phase Synthesis of 2,5-Disubstituted 1,3-Azoles. Preliminary Antibacterial Activity Studies.
A small library of compounds with an oxa(thia)zole scaffold and structural diversity in both positions 2 and 5 has been synthesized. Double acylation of a protected glycine affords intermediate alpha-amido-beta-ketoesters, which in turn can be dehydrated to afford 1,3-oxazoles or reacted with Lawesson's reagent to furnish 1,3-thiazoles. This procedure was designed with its adaptation to fluorous techniques in mind. Thus, when a protected glycine with a fluorous tag in the ester moiety is used as a starting material, the synthesis can be easily completed without column chromatography purification of intermediate compounds with good to excellent yields, thus affording a suitable entry to the …