Deriving electrophysiological brain network connectivity via tensor component analysis during freely listening to music
Recent studies show that the dynamics of electrophysiological functional connectivity is attracting more and more interest since it is considered as a better representation of functional brain networks than static network analysis. It is believed that the dynamic electrophysiological brain networks with specific frequency modes, transiently form and dissolve to support ongoing cognitive function during continuous task performance. Here, we propose a novel method based on tensor component analysis (TCA), to characterize the spatial, temporal, and spectral signatures of dynamic electrophysiological brain networks in electroencephalography (EEG) data recorded during free music-listening. A thr…
Lepton jets from radiating dark matter
Journal of High Energy Physics 2015.7 (2015): 045 reproduced by permission of Scuola Internazionale Superiore di Studi Avanzati (SISSA)
Corrigendum to ‘Automated detection and localization system of myocardial infarction in single-beat ECG using Dual-Q TQWT and wavelet packet tensor decomposition’ [Computer Methods and Programs in Biomedicine 184 (2020) 105120]
Searching for long-lived particles beyond the Standard Model at the Large Hadron Collider
Particles beyond the Standard Model (SM) can generically have lifetimes that are long compared to SM particles at the weak scale. When produced at experiments such as the Large Hadron Collider (LHC) at CERN, these longlived particles (LLPs) can decay far from the interaction vertex of the primary proton–proton collision. Such LLP signatures are distinct from those of promptly decaying particles that are targeted by the majority of searches for new physics at the LHC, often requiring customized techniques to identify, for example, significantly displaced decay vertices, tracks with atypical properties, and short track segments. Given their non-standard nature, a comprehensive overview of LLP…
Dark gamma-ray bursts
Many theories of dark matter (DM) predict that DM particles can be captured by stars via scattering on ordinary matter. They subsequently condense into a DM core close to the center of the star and eventually annihilate. In this work, we trace DM capture and annihilation rates throughout the life of a massive star and show that this evolution culminates in an intense annihilation burst coincident with the death of the star in a core collapse supernova. The reason is that, along with the stellar interior, also its DM core heats up and contracts, so that the DM density increases rapidly during the final stages of stellar evolution. We argue that, counterintuitively, the annihilation burst is …
Distinct Patterns of Functional Connectivity During the Comprehension of Natural, Narrative Speech.
Recent continuous task studies, such as narrative speech comprehension, show that fluctuations in brain functional connectivity (FC) are altered and enhanced compared to the resting state. Here, we characterized the fluctuations in FC during comprehension of speech and time-reversed speech conditions. The correlations of Hilbert envelope of source-level EEG data were used to quantify FC between spatially separate brain regions. A symmetric multivariate leakage correction was applied to address the signal leakage issue before calculating FC. The dynamic FC was estimated based on a sliding time window. Then, principal component analysis (PCA) was performed on individually concatenated and te…
Automated detection and localization system of myocardial infarction in single-beat ECG using Dual-Q TQWT and wavelet packet tensor decomposition.
Abstract Background and objective It is challenging to conduct real-time identification of myocardial infarction (MI) due to artifact corruption and high dimensionality of multi-lead electrocardiogram (ECG). In the present study, we proposed an automated single-beat MI detection and localization system using dual-Q tunable Q-factor wavelet transformation (Dual-Q TQWT) denoising algorithm. Methods After denoising and segmentation of ECG, a fourth-order wavelet tensor (leads × subbands × samples × beats) was constructed based on the discrete wavelet packet transform (DWPT), to represent the features considering the information of inter-beat, intra-beat, inter-frequency, and inter-lead. To red…
Analysis of Somatosensory Cortical Responses to Different Electrotactile Stimulations as a Method Towards an Objective Definition of Artificial Sensory Feedback Stimuli : An MEG Pilot Study
Sensory feedback is a critical component in many human-machine interfaces (e.g., bionic limbs) to provide missing sensations. Specifically, electrotactile stimulation is a popular feedback modality able to evoke configurable sensations by modulating pulse amplitude, duration, and frequency of the applied stimuli. However, these sensations coded by electrotactile parameters are thus far predominantly determined by subjective user reports, which leads to heterogeneous and unstable feedback delivery. Thus, a more objective understanding of the impact that different stimulation parameters induce in the brain, is needed. Analysis of cortical responses to electrotactile afference might be an effe…
Epigenetic modifiers are necessary but not sufficient for reprogramming non-myelinating cells into myelin gene-expressing cells.
Background Modifications on specific histone residues and DNA methylation play an essential role in lineage choice and cellular reprogramming. We have previously shown that histone modifications or combinatorial codes of transcription factors (TFs) are critical for the differentiation of multipotential progenitors into myelinating oligodendrocytes. In this study we asked whether combining global manipulation of DNA methylation and histone acetylation together with the expression of oligodendrocyte- specific TFs, was sufficient to switch the identity of fibroblasts into myelin gene-expressing cells. Methodology/Principal Findings Transfection of six oligodendrocyte-specific TFs (Olig1, Olig2…
Sustaining Attention for a Prolonged Duration Affects Dynamic Organizations of Frequency-Specific Functional Connectivity
Sustained attention encompasses a cascade of fundamental functions. The human ability to implement a sustained attention task is supported by brain networks that dynamically formed and dissolved through oscillatory synchronization. The decrement of vigilance induced by prolonged task engagement affects sustained attention. However, little is known about which stage or combinations are affected by vigilance decrement. Here, we applied an analysis framework composed of weighted phase lag index (wPLI) and tensor component analysis (TCA) to an EEG dataset collected during 80 min sustained attention task to examine the electrophysiological basis of such effect. We aimed to characterize the phase…
Automated detection and localization system of myocardial infarction in single-beat ECG using Dual-Q TQWT and wavelet packet tensor decomposition
Background and objective. It is challenging to conduct real-time identification of myocardial infarction (MI) due to artifact corruption and high dimensionality of multi-lead electrocardiogram (ECG). In the present study, we proposed an automated single-beat MI detection and localization system using dual-Q tunable Q-factor wavelet transformation (Dual-Q TQWT) denoising algorithm. Methods. After denoising and segmentation of ECG, a fourth-order wavelet tensor (leads × subbands × samples × beats) was constructed based on thediscretewavelet packet transform (DWPT), to represent the features considering the information of inter-beat, intra-beat, inter-frequency, and inter-lead. To reduce the t…
Impeded Dark Matter
We consider dark matter models in which the mass splitting between the dark matter particles and their annihilation products is tiny. Compared to the previously proposed Forbidden Dark Matter scenario, the mass splittings we consider are much smaller, and are allowed to be either positive or negative. To emphasize this modification, we dub our scenario "Impeded Dark Matter". We demonstrate that Impeded Dark Matter can be easily realized without requiring tuning of model parameters. For negative mass splitting, we demonstrate that the annihilation cross-section for Impeded Dark Matter depends linearly on the dark matter velocity or may even be kinematically forbidden, making this scenario al…
Fast Estimation of Diffusion Tensors under Rician noise by the EM algorithm
Diffusion tensor imaging (DTI) is widely used to characterize, in vivo, the white matter of the central nerve system (CNS). This biological tissue contains much anatomic, structural and orientational information of fibers in human brain. Spectral data from the displacement distribution of water molecules located in the brain tissue are collected by a magnetic resonance scanner and acquired in the Fourier domain. After the Fourier inversion, the noise distribution is Gaussian in both real and imaginary parts and, as a consequence, the recorded magnitude data are corrupted by Rician noise. Statistical estimation of diffusion leads a non-linear regression problem. In this paper, we present a f…
Exposing dark sector with futureZ-factories
We investigate the prospects of searching dark sector models via exotic [Formula: see text]-boson decay at future [Formula: see text] colliders with Giga [Formula: see text] and Tera [Formula: see text] options. Four general categories of dark sector models: Higgs portal dark matter, vector portal dark matter, inelastic dark matter and axion-like particles, are considered. Focusing on channels motivated by the dark sector models, we carry out a model independent study of the sensitivities of [Formula: see text]-factories in probing exotic decays. The limits on branching ratios of the exotic [Formula: see text] decay are typically [Formula: see text] for the Giga [Formula: see text] and [For…
Inside Back Cover: Microarray Analysis of Antibodies Induced with Synthetic Antitumor Vaccines: Specificity against Diverse Mucin Core Structures (Chem. Eur. J. 16/2017)
Fuzzy Dark Matter and Non-Standard Neutrino Interactions
We discuss novel ways in which neutrino oscillation experiments can probe dark matter. In particular, we focus on interactions between neutrinos and ultra-light ("fuzzy") dark matter particles with masses of order $10^{-22}$ eV. It has been shown previously that such dark matter candidates are phenomenologically successful and might help ameliorate the tension between predicted and observed small scale structures in the Universe. We argue that coherent forward scattering of neutrinos on fuzzy dark matter particles can significantly alter neutrino oscillation probabilities. These effects could be observable in current and future experiments. We set new limits on fuzzy dark matter interacting…
Distinct Patterns of Functional Connectivity During the Comprehension of Natural, Narrative Speech
Recent continuous task studies, such as narrative speech comprehension, show that fluctuations in brain functional connectivity (FC) are altered and enhanced compared to the resting state. Here, we characterized the fluctuations in FC during comprehension of speech and time-reversed speech conditions. The correlations of Hilbert envelope of source-level EEG data were used to quantify FC between spatially separate brain regions. A symmetric multivariate leakage correction was applied to address the signal leakage issue before calculating FC. The dynamic FC was estimated based on a sliding time window. Then, principal component analysis (PCA) was performed on individually concatenated and tem…
Network Entropy for the Sequence Analysis of Functional Connectivity Graphs of the Brain
Dynamic representation of functional brain networks involved in the sequence analysis of functional connectivity graphs of the brain (FCGB) gains advances in uncovering evolved interaction mechanisms. However, most of the networks, even the event-related ones, are highly heterogeneous due to spurious interactions, which bring challenges to revealing the change patterns of interactive information in the complex dynamic process. In this paper, we propose a network entropy (NE) method to measure connectivity uncertainty of FCGB sequences to alleviate the spurious interaction problem in dynamic network analysis to realize associations with different events during a complex cognitive task. The p…
Return of the X-rays: A New Hope for Fermionic Dark Matter at the keV Scale
A long time ago (in 2014), in galaxies and galaxy clusters far, far away, several groups have reported hints for a yet unidentified line in astrophysical X-ray signals at an energy of 3.5\,keV. While it is not unlikely that this line is simply a reflection of imperfectly modeled atomic transitions, it has renewed the community's interest in models of keV-scale dark matter, whose decay would lead to such a line. The alternative possibility of dark matter annihilation into monochromatic photons is far less explored, a lapse that we strive to amend in this paper. More precisely, we introduce a novel model of fermionic dark matter $\chi$ with $\mathcal{O}(\text{keV})$ mass, annihilating to a sc…
X-Ray Lines from Dark Matter Annihilation at the keV Scale.
In 2014, several groups reported hints for a yet unidentified line in astrophysical x-ray signals from galaxies and galaxy clusters at an energy of 3.5 keV. While it is not unlikely that this line is simply a reflection of imperfectly modeled atomic transitions, it has renewed the community’s interest in models of keV-scale dark matter, whose decay would lead to such a line. The alternative possibility of dark matter annihilation into monochromatic photons is far less explored, a lapse that we strive to amend in this Letter. More precisely, we introduce a novel model of fermionic dark matter χ with O(keV) mass, annihilating to a scalar state ϕ which in turn decays to photons, for instance v…
Precise Measurement of the e+e−→π+π−J/ψ Cross Section at Center-of-Mass Energies from 3.77 to 4.60 GeV
The cross section for the process e(+)e(-)-> pi(+) pi(-) J/psi is measured precisely at center-of-mass energies from 3.77 to 4.60 GeV using 9 fb(-1) of data collected with the BESIII detector operating at the BEPCII storage ring. Two resonant structures are observed in a fit to the cross section. The first resonance has a mass of (222.0 +/- 3.1 +/- 1.4) MeV/ c(2) and a width of (44.1 +/- 4.3 +/- 2.0)MeV, while the second one has a mass of (4320.0 +/- 10.4 +/- 7.0)MeV/c(2) and a width of (101.4(- 19.7)(+25.3) +/- 10.2) MeV, where the first errors are statistical and second ones are systematic. The first resonance agrees with the Y(4260) resonance reported by previous experiments. The precisi…
Discovering dynamic task-modulated functional networks with specific spectral modes using MEG.
Efficient neuronal communication between brain regions through oscillatory synchronization at certain frequencies is necessary for cognition. Such synchronized networks are transient and dynamic, established on the timescale of milliseconds in order to support ongoing cognitive operations. However, few studies characterizing dynamic electrophysiological brain networks have simultaneously accounted for temporal non-stationarity, spectral structure, and spatial properties. Here, we propose an analysis framework for characterizing the large-scale phase-coupling network dynamics during task performance using magnetoencephalography (MEG). We exploit the high spatiotemporal resolution of MEG to m…
New signatures of flavor violating Higgs couplings
We explore several novel LHC signatures arising from quark or lepton flavor violating couplings in the Higgs sector, and we constrain such couplings using LHC data. Since the largest signals are possible in channels involving top quarks or tau leptons, we consider in particular the following flavor violating processes: (1) $pp \to thh$ (top plus di-Higgs final state) arising from a dimension six coupling of up-type quarks to three insertions of the Higgs field. We develop a search strategy for this final state and demonstrate that detection is possible at the high luminosity LHC if flavor violating top--up--Higgs couplings are not too far below the current limit. (2) $pp \to tH^0$, where $H…
The Combined Effects of Ethylene and MeJA on Metabolic Profiling of Phenolic Compounds in Catharanthus roseus Revealed by Metabolomics Analysis
Phenolic compounds belong to a class of secondary metabolites and are implicated in a wide range of responsive mechanisms in plants triggered by both biotic and abiotic elicitors. In this study, we approached the combinational effects of ethylene and MeJA (methyl jasmonate) on phenolic compounds profiles and gene expressions in the medicinal plant Catharanthus roseus. In virtue of a widely non-targeted metabolomics method, we identified a total of 34 kinds of phenolic compounds in the leaves, composed by 7 C6C1-, 11 C6C3-, and 16 C6C3C6 compounds. In addition, 7 kinds of intermediates critical for the biosynthesis of phenolic compounds and alkaloids were identified and discussed with phenol…
Dynamic Community Detection for Brain Functional Networks during Music Listening with Block Component Analysis
Publisher Copyright: Author The human brain can be described as a complex network of functional connections between distinct regions, referred to as the brain functional network. Recent studies show that the functional network is a dynamic process and its community structure evolves with time during continuous task performance. Consequently, it is important for the understanding of the human brain to develop dynamic community detection techniques for such time-varying functional networks. Here, we propose a temporal clustering framework based on a set of network generative models and surprisingly it can be linked to Block Component Analysis to detect and track the latent community structure…
Microarray analysis of antibodies induced with synthetic antitumor vaccines : specificity against diverse mucin core structures
Glycoprotein research is pivotal for vaccine development and biomarker discovery. Many successful methodologies for reliably increasing the antigenicity toward tumor-associated glycopeptide structures have been reported. Deeper insights into the quality and specificity of the raised polyclonal, humoral reactions are often not addressed, despite the fact that an immunological memory, which produces antibodies with cross-reactivity to epitopes exposed on healthy cells, may cause autoimmune diseases. In the current work, three MUC1 antitumor vaccine candidates conjugated with different immune stimulants are evaluated immunologically. For assessment of the influence of the immune stimulant on a…
The coannihilation codex
We present a general classification of simplified models that lead to dark matter (DM) coannihilation processes of the form DM + X $\rightarrow$ SM$_1$ + SM$_2$, where X is a coannihilation partner for the DM particle and SM$_1$, SM$_2$ are Standard Model fields. Our classification also encompasses regular DM pair annihilation scenarios if DM and X are identical. Each coannhilation scenario motivates the introduction of a mediating particle M that can either belong to the Standard Model or be a new field, whereby the resulting interactions between the dark sector and the Standard Model are realized as tree-level and dimension-four couplings. We construct a basis of coannihilation models, cl…
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Contains fulltext : 232759.pdf (Publisher’s version ) (Closed access) In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to…
Precise Measurement of the e+e− → π+π−J/ψ Cross Section at Center-of-Mass Energies from 3.77 to 4.60 GeV
The cross section for the process e(+)e(-)-> pi(+) pi(-) J/psi is measured precisely at center-of-mass energies from 3.77 to 4.60 GeV using 9 fb(-1) of data collected with the BESIII detector operating at the BEPCII storage ring. Two resonant structures are observed in a fit to the cross section. The first resonance has a mass of (222.0 +/- 3.1 +/- 1.4) MeV/ c(2) and a width of (44.1 +/- 4.3 +/- 2.0)MeV, while the second one has a mass of (4320.0 +/- 10.4 +/- 7.0)MeV/c(2) and a width of (101.4(- 19.7)(+25.3) +/- 10.2) MeV, where the first errors are statistical and second ones are systematic. The first resonance agrees with the Y(4260) resonance reported by previous experiments. The precisi…
Autophagy
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide…
Dissociable Effects of Reward on P300 and EEG Spectra Under Conditions of High vs. Low Vigilance During a Selective Visual Attention Task
The influence of motivation on selective visual attention in states of high vs. low vigilance is poorly understood. To explore the possible differences in the influence of motivation on behavioral performance and neural activity in high and low vigilance levels, we conducted a prolonged 2 h 20 min flanker task and provided monetary rewards during the 20- to 40- and 100- to 120-min intervals of task performance. Both the behavioral and electrophysiological measures were modulated by prolonged task engagement. Moreover, the effect of reward was different in high vs. low vigilance states. The monetary reward increased accuracy and decreased the reaction time (RT) and number of omitted response…
Exposing the dark sector with future Z factories
We investigate the prospects of searching dark sector models via exotic Z-boson decay at future e⁺e⁻ colliders with Giga Z and Tera Z options. Four general categories of dark sector models, Higgs portal dark matter, vector-portal dark matter, inelastic dark matter, and axionlike particles, are considered. Focusing on channels motivated by the dark sector models, we carry out a model-independent study of the sensitivities of Z factories in probing exotic decays. The limits on branching ratios of the exotic Z decay are typically O(10⁻⁶–10⁻[superscript 8.5]) for the Giga Z and O(10⁻[superscript 7.5]–10⁻¹¹) for the Tera Z, and they are compared with the projection for the high luminosity LHC. W…
A tale of two portals: testing light, hidden new physics at future e + e − colliders
We investigate the prospects for producing new, light, hidden states at a future $e^+ e^-$ collider in a Higgsed dark $U(1)_D$ model, which we call the Double Dark Portal model. The simultaneous presence of both vector and scalar portal couplings immediately modifies the Standard Model Higgsstrahlung channel, $e^+ e^- \to Zh$, at leading order in each coupling. In addition, each portal leads to complementary signals which can be probed at direct and indirect detection dark matter experiments. After accounting for current constraints from LEP and LHC, we demonstrate that a future $e^+ e^-$ Higgs factory will have unique and leading sensitivity to the two portal couplings by studying a host o…
When nanophotonics meet thin crystalline-silicon photovoltaics
11-18 sept. 2015; International audience; no abstract