0000000000073915
AUTHOR
Brunetto Chiarelli
Genetic aspects in hominid evolution
Genomic comparison between apes and humans have made important contributions to our understanding of human evolution. The modern period of karyological comparisons between humans and other primates began about forty years ago and has been marked by a series of technical revolutions. In the 1960s pioneering genetic and chromosomal comparisons of human and great apes suggested, as had Darwin a century before, that our closest relative were the African apes. Early immunological analyses placed human/apes divergence at about five million year ago. Acceptance of man’s late divergence from the African apes was delayed by the scarcity of paleontological evidence coupled with a fallacious Asiatic o…
Alia: Antropologia di una comunità dell'entroterra siciliano
In the spring of 1995, during works for the rehabilitation of a wall that closed the grotto of the Old Cemetery in the Sicilian village of Alia, the skeletal remains of the victims of the cholera outbreak of 1837 that had been rapidly interred here were brought to light. From that moment on, the Alia project was developed without interruption, analysing the biological evolution of the local population by exploiting study methods characteristic of different anthropological disciplines, such as skeletal biology, population genetics and biodemography. The book renders account of research completed and in progress carried out by academics from the Universities of Florence, Palermo, Parma, Cagli…
The selective advantage of cystic fibrosis heterozygotes tested by aDNA analysis: A preliminary investigation
Recently a heterozygote advantage was suggested to explain the high incidence (1:25 carrier individuals in Europeans) of the cystic fibrosis gene. This selective advantage was speculated to be due to a high resistance to chloride-secreting diarrhea, including cholera. Up to now the major efforts to test directly this hypothesis have been limited to animal models.
Biomolecular study of the human remains from tomb 5859 in the Etruscan necropolis of Monterozzi Tarquinia (Vitarbo, Italy)
Abstract Archaeological excavation in an Etruscan room tomb, from the Monterozzi necropolis in Tarquinia led to the recovery of four individuals. It was hypothesized that they could be members of a single family group. As both archaeological data and classical anthropological analysis provided little information in this direction, ancient DNA (aDNA) was extracted from bone and tooth fragments of the individuals. For each subject HVR-I of the mitochondrial DNA (mtDNA) was cloned and sequenced. To identify the sex of the individuals, amelogenine and SRY genes were analysed. Short tandem repeat (STR) characterization was also performed. DNA studies were preceded by the evaluation of amino acid…
Evolution of the Human chromosome 7: new information from the mapping of William-Breuren locus on non human primates chromosomes.
Human chromosome 7 (HSA7) derives, by a pericentric inversion and a paracentric inversion, from an ancestral chromosome homologous to chromosome 10 of Pongo pygmaeus (the Asiatic Orang-Utan). Nevertheless the genesis of this autosome during primates evolution is not clear. Even if chromosome painting shows that HAS 7 synteny is highly conserved, GTG-banding comparison in Hominoidea and Cercopithecoidea indicates the probable occurrence of complex rearrangements during the evolution. In this study we used a single locus FISH approach, a powerful tool to detect fine rearrangements, in order to investigate the evolution of HAS 7. We report the chromosome mapping of Williams-Beuren syndrome loc…