6533b834fe1ef96bd129d7d1
RESEARCH PRODUCT
The selective advantage of cystic fibrosis heterozygotes tested by aDNA analysis: A preliminary investigation
Luca SineoBarbara BramantiBarbara BramantiBrunetto ChiarelliDavid CaramelliSusanne HummelM. VianelloBernd Herrmannsubject
aDNAPathologymedicine.medical_specialtyCystic fibrosis genecystic fibrosis aDNA ancient DNAmedicine.disease_causeCystic fibrosisNOcystic fibrosis03 medical and health sciencesSelective advantagemedicineancient DNA030304 developmental biology0303 health sciencesbiology030305 genetics & heredityCholera toxinHeterozygote advantagemedicine.diseaseCholeraCystic fibrosis transmembrane conductance regulator3. Good healthDiarrheaAnthropologyImmunologybiology.proteinmedicine.symptomdescription
Recently a heterozygote advantage was suggested to explain the high incidence (1:25 carrier individuals in Europeans) of the cystic fibrosis gene. This selective advantage was speculated to be due to a high resistance to chloride-secreting diarrhea, including cholera. Up to now the major efforts to test directly this hypothesis have been limited to animal models.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-07-01 |