0000000000082926

AUTHOR

Daniele Andreini

showing 7 related works from this author

1-Year Outcomes of FFRCT-Guided Care in Patients With Suspected Coronary Disease

2016

Abstract Background Coronary computed tomographic angiography (CTA) plus estimation of fractional flow reserve using CTA (FFR CT ) safely and effectively guides initial care over 90 days in patients with stable chest pain. Longer-term outcomes are unknown. Objectives The study sought to determine the 1-year clinical, economic, and quality-of-life (QOL) outcomes of using FFR CT instead of usual care. Methods Consecutive patients with stable, new onset chest pain were managed by either usual testing (n = 287) or CTA (n = 297) with selective FFR CT (submitted in 201, analyzed in 177); 581 of 584 (99.5%) completed 1-year follow-up. Endpoints were adjudicated major adverse cardiac events (MACE) …

medicine.medical_specialtybusiness.industrymedicine.medical_treatmentFractional flow reserve030204 cardiovascular system & hematologymedicine.diseaseChest painRevascularization3. Good health030218 nuclear medicine & medical imagingCoronary artery disease03 medical and health sciences0302 clinical medicineQuality of lifeConventional PCIMedicineMyocardial infarctionRadiologymedicine.symptomCardiology and Cardiovascular MedicinebusinessMaceJournal of the American College of Cardiology
researchProduct

Appropriateness criteria for the use of cardiac computed tomography, SIC-SIRM part 2: Acute chest pain evaluation; Stent and coronary artery bypass g…

2022

In the past 20 years, cardiac computed tomography (CCT) has become a pivotal technique for the noninvasive diagnostic workup of coronary and cardiac diseases. Continuous technical and methodological improvements, combined with fast growing scientific evidence, have progressively expanded the clinical role of CCT. Randomized clinical trials documented the value of CCT in increasing the cost-effectiveness of the management of patients with acute chest pain presenting in the emergency department, also during the pandemic. Beyond the evaluation of stents and surgical graft patency, the anatomical and functional coronary imaging have the potential to guide treatment decision-making and planning …

Chest PainHeart DiseasesInterventionalCardiologyGeneral Medicineheart diseaseRadiology Interventionalvalve diseaseX-Ray Computedcoronary computed tomography scancoronary artery bypass graftNeoplasmsHumansStentsstentCoronary Artery BypassCardiology and Cardiovascular MedicineTomography X-Ray ComputedCardiomyopathiesRadiologychest pain; coronary artery bypass graft; coronary computed tomography scan; heart disease; stent; valve disease; Chest Pain; Coronary Artery Bypass; Humans; Radiology Interventional; Stents; Tomography X-Ray Computed; Cardiology; Cardiomyopathies; Heart Diseases; NeoplasmsTomographyvalve disease.
researchProduct

SIRM–SIC appropriateness criteria for the use of Cardiac Computed Tomography. Part 1: Congenital heart diseases, primary prevention, risk assessment …

2021

AbstractIn the past 20 years, Cardiac Computed Tomography (CCT) has become a pivotal technique for the noninvasive diagnostic work-up of coronary and cardiac diseases. Continuous technical and methodological improvements, combined with fast growing scientific evidence, have progressively expanded the clinical role of CCT. Recent large multicenter randomized clinical trials documented the high prognostic value of CCT and its capability to increase the cost-effectiveness of the management of patients with suspected CAD. In the meantime, CCT, initially perceived as a simple non-invasive technique for studying coronary anatomy, has transformed into a multiparametric “one-stop-shop” approach abl…

genetic structuresCardiac computed tomographyComputed Tomography AngiographyCoronary DiseaseCAD030204 cardiovascular system & hematologyChest painChest pain Congenital heart disease Coronary CT angiography Epicardial adipose tissue Plaque Stenosislaw.inventionChest painCongenital0302 clinical medicineRandomized controlled triallaw030212 general & internal medicineHeart DefectsPlaqueNeuroradiologyStenosismedicine.diagnostic_testCalcinosisHeartInterventional radiologyGeneral MedicineFractional Flow ReserveFractional Flow Reserve MyocardialPrimary PreventionPosition PaperChest pain; Congenital heart disease; Coronary CT angiography; Epicardial adipose tissue; Plaque; Stenosis; Calcinosis; Coronary Disease; Coronary Stenosis; Fractional Flow Reserve Myocardial; Heart; Heart Defects Congenital; Humans; Primary Prevention; Cardiac Imaging Techniques; Computed Tomography Angiography; Preoperative Caremedicine.symptomRisk assessmentHeart Defects Congenitalmedicine.medical_specialty03 medical and health sciencesEpicardial adipose tissuePreoperative CaremedicineMyocardialHumansRadiology Nuclear Medicine and imagingCoronary CT angiographyIntensive care medicineCongenital heart diseasebusiness.industryCoronary Stenosismedicine.diseaseCardiac Imaging TechniquesStenosisbusinessLa radiologia medica
researchProduct

Rationale and design of the Prospective LongitudinAl Trial of FFRCT: Outcome and Resource IMpacts study

2015

International audience; BACKGROUND: Fractional flow reserve (FFR) measured by coronary computed tomography angiography (FFRCT) has been validated against invasive FFR. However, there are no data on how the use of FFRCT affects patient care and outcomes. The aim of this study is to compare standard practice guided by usual care testing to FFRCT-guided management in symptomatic subjects with suspected coronary artery disease (CAD). METHODS: In this prospective nonrandomized trial, symptomatic patients with suspected CAD will be enrolled in 2 consecutive cohorts: a usual care-guided pathway (cohort 1) and an FFRCT-guided pathway (cohort 2). Each cohort is divided into 2 groups according to whe…

Malemedicine.medical_specialty*Tomography[SDV]Life Sciences [q-bio]Fractional flow reserveCoronary Artery DiseaseCoronary AngiographyCoronary Angiography/*methodsCoronary artery diseaseCoronary Artery Disease/*diagnosis/physiopathologyQuality of lifeRandomized Controlled Trials as Topic/*methodsPredictive Value of TestsMyocardial/*physiologyOutcome Assessment Health CareClinical endpointMedicineHumansProspective StudiesProspective cohort studyRandomized Controlled Trials as TopicAgedbusiness.industryMiddle Agedmedicine.diseaseFractional Flow Reserve3. Good healthX-Ray ComputedFractional Flow Reserve MyocardialStenosisPredictive value of testsCohortFemaleRadiologyOutcome Assessment (Health Care)/*methodsCardiology and Cardiovascular MedicinebusinessTomography X-Ray ComputedFollow-Up Studies
researchProduct

Quality-of-Life and Economic Outcomes of Assessing Fractional Flow Reserve With Computed Tomography Angiography: PLATFORM.

2015

International audience; BACKGROUND: Fractional flow reserve estimated using computed tomography (FFRCT) might improve evaluation of patients with chest pain. OBJECTIVES: The authors sought to determine the effect on cost and quality of life (QOL) of using FFRCT instead of usual care to evaluate stable patients with symptoms suspicious for coronary disease. METHODS: Symptomatic patients without known coronary disease were enrolled into 2 strata based on whether invasive or noninvasive diagnostic testing was planned. In each stratum, consecutive observational cohorts were evaluated with either usual care or FFRCT. The number of diagnostic tests, invasive procedures, hospitalizations, and medi…

Malemedicine.medical_specialtycost comparisonVisual analogue scale*Fractional Flow Reserve[SDV]Life Sciences [q-bio]Fractional flow reserveCoronary Artery Disease030204 cardiovascular system & hematologyChest painCoronary Angiography030218 nuclear medicine & medical imagingCoronary artery diseaseAnginaCohort Studiesquality of life03 medical and health sciencesCoronary Artery Disease/*economics/*radiography/therapy0302 clinical medicineQuality of lifeEQ-5DmedicineHumansLongitudinal StudiesProspective StudiesMyocardial/physiologyTomographyComputed tomography angiography*Quality of Lifemedicine.diagnostic_testbusiness.industryX-Ray Computed/*economicsMiddle Agedmedicine.diseaseCoronary Angiography/*economics3. Good healthFractional Flow Reserve MyocardialTreatment OutcomePhysical therapyQuality of Lifestress testFemalemedicine.symptombusinessCardiology and Cardiovascular MedicineTomography X-Ray Computedmyocardial fractional flow reserveJournal of the American College of Cardiology
researchProduct

Italian multicenter, prospective study to evaluate the negative predictive value of 16- and 64-slice MDCT imaging in patients scheduled for coronary …

2009

This was a prospective, multicenter study designed to evaluate the utility of MDCT in the diagnosis of coronary artery disease (CAD) in patients scheduled for elective coronary angiography (CA) using different MDCT systems from different manufacturers. Twenty national sites prospectively enrolled 367 patients between July 2004 and June 2006. Computed tomography (CT) was performed using a standardized/optimized scan protocol for each type of MDCT system (> or =16 slices) and compared with quantitative CA performed within 2 weeks of MDCT. A total of 284 patients (81%) were studied by 16-slice MDCT systems, while 66 patients (19%) by 64-slice MDCT scanners. The primary analysis was on-site/off…

Coronary angiographyAdultDiagnostic ImagingMalemedicine.medical_specialtyCoronary Artery DiseaseCoronary Angiographydiagnosis/radiographyCoronary artery diseasemethodsCoronary artery disease16- and 64-slice MDCT imaging coronary angiographySettore MED/36 - Diagnostica per Immagini e RadioterapiaPredictive Value of TestsCoronary Angiography/*methods Coronary Artery Disease/*diagnosis/*radiography Diagnostic Imaging/methods80 and overCardiac CTMedicineHumansRadiology Nuclear Medicine and imagingIn patientcardiovascular diseasesProspective StudiesProspective cohort studyTomographyNeuroradiologyAgedAged 80 and overmedicine.diagnostic_testbusiness.industryMultidetector CTNon invasiveReproducibility of ResultsInterventional radiologyGeneral MedicineAdult Aged Aged; 80 and over Coronary Angiography; methods Coronary Artery Disease; diagnosis/radiography Diagnostic Imaging; methods Female Humans Italy Male Middle Aged Predictive Value of Tests Prospective Studies Reproducibility of Results Tomography; X-Ray Computed; methodsMiddle Agedmedicine.diseasePredictive valueSettore MED/11 - Malattie Dell'Apparato CardiovascolareX-Ray Computedcoronary angiographyCTCardiac CT; Coronary artery disease; Multidetector CTItalyFemaleRadiologycoronary angiographybusinessTomography X-Ray Computed
researchProduct

Clinical evaluation of bempedoic acid for the treatment of hyperlipidaemia.

2021

Bempedoic acid (BA) is a novel first-in-class oral lipid-lowering therapy. BA has been approved by the European Medicinal Agency and Food and Drug Administration and has been commercialised throughout Europe since the end of 2020 as an add-on therapy in patients at high/very-high cardiovascular risk that are not at LDL-C goals with current lipid-lowering treatments. Recently, Italian lipid management experts gathered to discuss several open questions on BA characteristics and BArelated practical clinical issues. The panel permitted collection of its opinions in a ten Q&A format. Aim: The aim of this viewpoint is to discuss and answer several open questions on BA characteristics and BA-r…

ATP citrate lyaseEndocrinology Diabetes and MetabolismMedicine (miscellaneous)HyperlipidemiasPharmacologyLipid-lowering therapyLipid-lowering treatmentMedicineLDL-cholesterolHumansDicarboxylic AcidsHypolipidemic AgentsLdl cholesterolNutrition and DieteticsLipid managementbusiness.industryNovel LDL-C treatment.Fatty AcidsCholesterol LDLBempedoic acidNovel LDL-C treatmentATP citrate lyaseATP citrate lyase; bempedoic acid; LDL-cholesterol; lipid-lowering treatment; novel LDL-C treatmentLipid loweringCardiology and Cardiovascular MedicinebusinessClinical evaluationBempedoic acidNutrition, metabolism, and cardiovascular diseases : NMCD
researchProduct