6533b835fe1ef96bd129ea45
RESEARCH PRODUCT
Italian multicenter, prospective study to evaluate the negative predictive value of 16- and 64-slice MDCT imaging in patients scheduled for coronary angiography (NIMISCAD-Non Invasive Multicenter Italian Study for Coronary Artery Disease)
Riccardo MaranoCarlo LiguoriLorenzo Bonomo De Cobelli FrancescoAntonio Esposito Del Maschio AlessandroChristoph BeckerChristopher HerzogMaurizio CentonzeDaniela CoserGiovanni MoranaElisabetta Salviato Gualdi Gian FrancoEmanuele CascianiGuido LigabueFederica FiocchiGianluca PontoneDaniele AndreiniCarlo CatalanoIacopo CarboneDante ChiappinoMassimo MidiriGiovanni SimonettiFilippo MarchisioLucio OlivettiRossella FattoriArnaldo ScardapaneMassimo PrincipiLuigia RomanoNicola ArcadiManuel ProfiliLuca Volterranisubject
Coronary angiographyAdultDiagnostic ImagingMalemedicine.medical_specialtyCoronary Artery DiseaseCoronary Angiographydiagnosis/radiographyCoronary artery diseasemethodsCoronary artery disease16- and 64-slice MDCT imaging coronary angiographySettore MED/36 - Diagnostica per Immagini e RadioterapiaPredictive Value of TestsCoronary Angiography/*methods Coronary Artery Disease/*diagnosis/*radiography Diagnostic Imaging/methods80 and overCardiac CTMedicineHumansRadiology Nuclear Medicine and imagingIn patientcardiovascular diseasesProspective StudiesProspective cohort studyTomographyNeuroradiologyAgedAged 80 and overmedicine.diagnostic_testbusiness.industryMultidetector CTNon invasiveReproducibility of ResultsInterventional radiologyGeneral MedicineAdult Aged Aged; 80 and over Coronary Angiography; methods Coronary Artery Disease; diagnosis/radiography Diagnostic Imaging; methods Female Humans Italy Male Middle Aged Predictive Value of Tests Prospective Studies Reproducibility of Results Tomography; X-Ray Computed; methodsMiddle Agedmedicine.diseasePredictive valueSettore MED/11 - Malattie Dell'Apparato CardiovascolareX-Ray Computedcoronary angiographyCTCardiac CT; Coronary artery disease; Multidetector CTItalyFemaleRadiologycoronary angiographybusinessTomography X-Ray Computeddescription
This was a prospective, multicenter study designed to evaluate the utility of MDCT in the diagnosis of coronary artery disease (CAD) in patients scheduled for elective coronary angiography (CA) using different MDCT systems from different manufacturers. Twenty national sites prospectively enrolled 367 patients between July 2004 and June 2006. Computed tomography (CT) was performed using a standardized/optimized scan protocol for each type of MDCT system (> or =16 slices) and compared with quantitative CA performed within 2 weeks of MDCT. A total of 284 patients (81%) were studied by 16-slice MDCT systems, while 66 patients (19%) by 64-slice MDCT scanners. The primary analysis was on-site/off-site evaluation of the negative predictive value (NPV) on a per-patient basis. Secondary analyses included on-site evaluation on a per-artery and per-segment basis. On-site evaluation included 327 patients (CAD prevalence 58%). NPV, positive predictive value (PPV), sensitivity, specificity, and diagnostic accuracy (DA) were 0.91 (95% CI 0.85-0.95), 0.91 (95% CI 0.86-0.95), 0.94 (95% CI 0.89-0.97), 0.88 (95% CI 0.81-0.93), and 0.91 (95% CI 0.88-0.94), respectively. Off-site analysis included 295 patients (CAD prevalence 56%). NPV, PPV, sensitivity, specificity, and DA were 0.73 (95% CI 0.65-0.79), 0.93 (95% CI 0.87-0.97), 0.73 (95% CI 0.65-0.79), 0.93 (95% CI 0.87-0.97), and 0.82 (95% CI 0.77-0.86), respectively. The results of this study demonstrate the utility of MDCT in excluding significant CAD even when conducted by centers with varying degrees of expertise and using different MDCT machines.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-01-01 |