0000000000121728
AUTHOR
Marcos Antonio Lloret-durà
Factors related to early castration resistance in metastatic prostate cancer. Results from the National Prostate Cancer Registry in Spain
Abstract Introduction The objective of the study was to determine the factors independently related with the development of castration resistance (CR) in prostate cancer (PC) in the medium term. Material and methods 155 patients diagnosed with metastatic PC with a follow-up of up to 39 months. Data taken from the National PC Registry. The evaluated variables were age, PSA, nadir PSA, Gleason, perineural invasion, TNM stages, and ADT type (intermittent / continuous). Results Mean follow-up 26,2 ± 13,4 months. 47.1% developed early CR, with mean time until onset of 12,2 ± 8,7 months. Univariate analysis: the mean PSA was correlated with CR (290 ± 905,1 ng/mL in non CR, 519,1 ± 1437,2 ng/mL in…
Factores relacionados con la resistencia a la castración precoz en el cáncer de próstata metastásico. Resultados del Registro nacional de cáncer de próstata en España
Resumen Introduccion El objetivo del estudio fue establecer los factores que se relacionan de forma independiente con el desarrollo de resistencia a la castracion (RC) a medio plazo en el cancer de prostata (CP). Material y metodos Ciento cincuenta y cinco pacientes con CP metastasicos al diagnostico del registro nacional de CP con un seguimiento de hasta 39 meses. Las variables estudiadas fueron: edad, PSA, nadir de PSA, Gleason, invasion perineural, estadios T, N y M y tipo de bloqueo (intermitente/continuo). Resultados Media de seguimiento 26,2 ± 13,4 meses. El 47,1% desarrollo RC precoz, con una media hasta el desarrollo de RC 12,2 ± 8,7 meses. Analisis univariante: se relacionaron con …
Ureteral realignment with combined access as a treatment of complete ureteral transection.
Ureteral realignment using a ureteral stent can be an alternative treatment in cases of complete ureteral transection and may avoid the need for reconstructive surgery. The combined access can help the passage of the guidewire through the injured area and the threading of the urinary system of the patient. We present a case of a 38-year-old man with multiples abdominal surgeries, who underwent a complete ureteral section treated with ureteral realignment with combined access. The subsequent evolution was favourable, with resolution of the ureteral injury at the acute time, and without the presence of long-term obstruction. Although we must accept that the standard treatment of the complete …