Tissue inflammatory biomarkers in chronic plaque psoriasis: Exploring lesional versus non‐lesional skin relative expression and possible clinical correlations

Incidencia de cáncer cutáneo distinto del melanoma en pacientes tratados con PUVA oral

Resumen Introduccion Los trabajos que determinan la incidencia de cancer cutaneo no melanoma (CCNM) en la poblacion tratada con psoralenos orales + UVA son heterogeneos, dependen de la localizacion geografica de la poblacion estudiada y tienen periodos de seguimiento cortos. El objetivo del trabajo es determinar la seguridad a largo plazo de la PUVAterapia y en concreto determinar la incidencia de CCNM en los pacientes tratados con PUVAterapia oral en el area mediterranea. Material y metodo Se ha realizado un estudio longitudinal de seguimiento retrospectivo, recogiendo 234 pacientes tratados con PUVA sistemico entre 1982 y 1996 con un seguimiento hasta mayo de 2017. Se ha calculado la dens…

Intensification therapy with golimumab: a new treatment strategy for moderate-severe refractory psoriasis

Steroid-resistant eosinophilic fasciitis successfully treated with addition of extracorporeal photopheresis.

Eosinophilic fasciitis (EF) is an uncommon fibrosing disease of the fascia with characteristic cutaneous and hematologic manifestations. Although EF is most commonly treated with corticosteroids at the beginning, a considerable number of patients show an inadequate response and hence various therapeutic strategies have been tried, including extracorporeal photopheresis (ECP). We describe the case of a 66-year-old woman with steroid-resistant EF that improved significantly after ECP was added to her treatment regimen. To date, only six cases of this therapeutic strategy have been reported in English literature.

Implanted Intestinal Mucosa on the Skin After an Ileostomy

Incidence of non-melanoma skin cancer in patients treated with psoralen and ultraviolet A therapy.

Abstract Introduction Studies reporting incidences of non-melanoma skin cancer (NMSC) are heterogeneous, depend on the geographic area of the studied population and are often short-term. The aim of this study is to determine the incidence of NMSC in patients treated with oral PUVA therapy in the Mediterranean area. Material and methods A retrospective, observational study was carried out with a sample of 234 patients treated with systemic PUVA between 1982 and 1996, carrying out a historical follow-up until May 2017. The incidence density rate of CCNM (crude and adjusted) was calculated by direct standardisation. The incidence of CCNM was compared with that reported in the general populatio…