0000000000131631
AUTHOR
Audrey Martin
Contrôle périopératoire de la pression artérielle
Resume L’hypotension arterielle perioperatoire est frequente. Elle est associee a la survenue de deces, de lesions renales, myocardiques et cerebralesBien qu'il n’existe pas de definition consensuellel’effet de l’hypotension arterielle est connu comme etant la resultante d’un effet seuil et temps (plus de 10 min en dessous de 80 mmHg de pression arterielle moyenne (PAM)). Il convient d’individualiser les objectifs en fonction du terrain du patient et du risque operatoire. Chez le sujet sain, une PAM de 60–65 mmHg semblerait suffisante, alors que chez le sujet avec un risque operatoire plus eleve, une PAM superieure a 75–80 mmHg et/ou des variations inferieures a 10–20 % de la valeur de base…
Evaluation of the Oxiris Membrane in Cardiogenic Shock Requiring Extracorporeal Membrane Oxygenation Support: Study Protocol for a Single Center, Single-Blind, Randomized Controlled Trial
Background: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is the rescue treatment proposed to patients with refractory cardiogenic shock. The VA-ECMO implantation promotes inflammation and ischemia-reperfusion injuries through the VA-ECMO flow, causing digestive mucosa barrier disrupture and inducing translocation of bacterial wall components—Lipopolysaccharides (LPS) with further inflammation and circulatory impairment. LPS is a well-studied surrogate indicator of bacterial translocation. Oxiris membrane is a promising and well-tolerated device that can specifically remove LPS. The main study aim is to compare the LPS elimination capacity of Oxiris membrane vs. a non-absorban…
Vasopressor-Sparing Strategies in Patients with Shock: A Scoping-Review and an Evidence-Based Strategy Proposition
Despite the abundant literature on vasopressor therapy, few studies have focused on vasopressor-sparing strategies in patients with shock. We performed a scoping-review of the published studies evaluating vasopressor-sparing strategies by analyzing the results from randomized controlled trials conducted in patients with shock, with a focus on vasopressor doses and/or duration reduction. We analyzed 143 studies, mainly performed in septic shock. Our analysis demonstrated that several pharmacological and non-pharmacological strategies are associated with a decrease in the duration of vasopressor therapy. These strategies are as follows: implementing a weaning strategy, vasopressin use, system…