0000000000136048

AUTHOR

Mr Sajeva

showing 9 related works from this author

In-hospital death and adverse clinical events in elderly patients according to disease clustering: The REPOSI study

2010

OBJECTIVE: The aim of the study was to recognize clusters of diseases among hospitalized elderly and to identify groups of patients at risk of in-hospital death and adverse clinical events according to disease clustering. METHOD: This was a cross-sectional study conducted in 38 internal medicine and geriatric wards in Italy participating in the Registro Politerapie SIMI (REPOSI) study during 2008. The subjects were 1,332 inpatients aged 65 years or older. Clusters of diseases (i.e., two or more co-occurrent diseases) were identified using the odds ratios (OR) for the associations between pairs of conditions, followed by cluster analysis. Logistic regression models were used to evaluate the …

MaleAgingDisease clustersPediatricsmedicine.medical_specialtySettore MED/09 - Medicina InternaHospital unitDiseaseHospital mortalitydisease clusteringLogistic regressionNO80 and overMedicineCluster AnalysisHumansHospital MortalityAgedAged 80 and overIn hospital deathMedical Errorsbusiness.industryClinical eventsAged; Aged 80 and over; Cluster Analysis; Female; Hospital Mortality; Humans; Italy; Male; Medical ErrorsREPOSIIn-hospital death; elderly patients; disease clustering; REPOSIIn-hospital deathOdds ratioSettore MED/45 - Scienze Infermieristiche Generali Cliniche E Pediatricheelderly patientItalyFemaleGeriatrics and Gerontologybusinesspatients at risk of in-hospital death; adverse clinical events according to disease clustering
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In-hospital death according to dementia diagnosis in acutely ill elderly patients: the REPOSI study.

2011

The aim of the study was to explore the association of dementia with in-hospital OBJECTIVE:The aim of the study was to explore the association of dementia with in-hospital death in acutely ill medical patients. METHODS: Thirty-four internal medicine and 4 geriatric wards in Italy participated in the Registro Politerapie SIMI-REPOSI-study during 2008. One thousand three hundred and thirty two in-patients aged 65 years or older were enrolled. Logistic regression models were used to evaluate the association of dementia with in-hospital death. Socio-demographic characteristics, morbidity (single diseases and the Charlson Index), number of drugs, and adverse clinical events during hospitalizatio…

Malemedicine.medical_specialtyPediatricsSettore MED/09 - Medicina InternaMEDLINECharlson indexLogistic regressionNOolder patientSex FactorsAcute illnesses Dementia Hospitalization Mortality Older patientsmental disordersmedicineDementiaHumansDementia diagnosisHospital MortalityIntensive care medicineAgedIn hospital deathAged 80 and overbusiness.industryacute illnessesConfoundingAge Factorsrisk of deathmedicine.diseaseSettore MED/45 - Scienze Infermieristiche Generali Cliniche E Pediatrichemortalityolder patientsacute illnessePsychiatry and Mental healthPneumoniahospital admissionLogistic ModelsAcute DiseaseDementiaFemaleGeriatrics and Gerontologybusinessdementia; risk of death; hospital admissionhospitalizationInternational journal of geriatric psychiatry
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Risk factors for hospital readmission of elderly patients

2012

Background: The aim of this study was to identify which factors were associated with a risk of hospital readmission within 3 months after discharge of a sample of elderly patients admitted to internal medicine and geriatric wards. Methods: Of the 1178 patients aged 65 years or more and discharged from one of the 66 wards of the 'Registry Politerapie SIMI (REPOSI)' during 2010, 766 were followed up by phone interview 3 months after discharge and were included in this analysis. Univariate and multivariate logistic regression models were used to evaluate the association of several variables with rehospitalization within 3 months from discharge. Results: Nineteen percent of patients were readmi…

MaleSettore MED/09 - Medicina InternaTime FactorsRisk factors; internal medicine; Geriatric patient; hospital admissionLogistic regressionElderly; Hospital readmission; Internal medicine and geriatric wards; Risk factorsElderlyInternal medicine and geriatric wards80 and overElderly; Hospital readmission; Internal medicine and geriatric wards; Risk factors; Aged; Aged 80 and over; Female; Geriatrics; Hospital Departments; Humans; Internal Medicine; Male; Patient Readmission; Risk Factors; Time Factors; Internal MedicineMedical diagnosisAged Aged; 80 and over Female Geriatrics Hospital Departments Humans Internal Medicine Male Patient Readmission; statistics /&/ numerical data Risk Factors Time FactorsAged 80 and overGeriatricsUnivariate analysisvascular diseaseHospital readmissionSettore MED/45 - Scienze Infermieristiche Generali Cliniche E PediatricheAgeing; readmissionstatistics /&/ numerical dataHospital DepartmentFemaleliver diseaseHumanmedicine.medical_specialtyTime FactorHospital DepartmentsMEDLINEHospital readmission Internal medicine and geriatric wards Risk factors Elderlyelderly patientsPatient ReadmissionNOInternal MedicinemedicineHumansRegistry Politerapie SIMI (REPOSI)Adverse effectAgedreadmissionbusiness.industryRisk FactorUnivariatemedicine.diseaseComorbidityHospital readmission; elderly patients; Registry Politerapie SIMI (REPOSI); vascular disease; liver diseaseHospital readmission; Internal medicine and geriatric wards; Risk factors; Elderlyelderly; hospital readmission; risk factors; internal medicine and geriatric wardsInternal medicine and geriatric wardAgeingGeriatric patienthospital admissionRisk factorsGeriatricsEmergency medicinebusinessGeriatricEuropean Journal of Internal Medicine
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Patterns of infections in older patients acutely admitted to medical wards: data from the REPOSI register

2019

In older adults infections are among the leading causes of emergency department visits, hospitalization, morbidity and mortality [1–3]. Infections also occur as adverse events during hospitalization, as highlighted by the large use of antibiotics in this setting, resulting in an increase of hospitalization length and mortality rate [4–6]. There is a paucity of studies, especially in European countries, that did offer a general pattern on all the types of infections occurring in acutely hospitalized older patients, being the literature mainly focused on single type of infections (i.e. pneumonia and urinary tract infections). To fill this gap of knowledge, we chose to observe and describe the…

Malemedicine.medical_specialtyMEDLINESocio-culturaleInfectionsComorbidities Hospitalizations Infections Older peopleComorbiditiesOlder patientsPatients' Rooms80 and overInternal MedicinePatients' Rooms.HumansMedicineLS4_4AgedAged 80 and overHospitalizationsbusiness.industryComorbidities; Hospitalizations; Infections; Older peopleHospitalizationPatient roomItalyRegister (music)Emergency medicineEmergency MedicineFemaleComorbidities; Hospitalizations; Infections; Older people; Aged; Aged 80 and over; Female; Hospitalization; Humans; Infections; Italy; Male; Patients' RoomsComorbiditieOlder peopleInfectionOlder peoplebusiness
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Antibiotic use and associated factors in a large sample of hospitalised older people

2019

Objectives: The aims of this study were to assess (i) the prevalence of antibiotic use, (ii) factors associated with their use and (iii) the association with in-hospital mortality in a large sample of hospitalised older people in Italy.Methods: Data were obtained from the 2010-2017 REPOSI register held in more than 100 internal medicine and geriatric wards in Italy. Patients aged >= 65 years with at least one antibiotic prescription during their hospitalisation were selected. Multivariable logistic regression models were used to determine factors associated with antibiotic use.Results: A total of 5442 older patients were included in the analysis, of whom 2786 (51.2%) were prescribed anti…

RegistrieMale0301 basic medicineAntibioticsLogistic regression0302 clinical medicineDrug Prescription80 and overPrevalenceImmunology and AllergyLS4_4Hospital MortalityRegistries030212 general & internal medicineMultivariate AnalysiRespiratory Tract InfectionsAged 80 and overAnti-Bacterial AgentsHospitalizationItalyAntibiotic useFemaleHumanMicrobiology (medical)medicine.medical_specialtyLogistic ModelInternal medicine wardmedicine.drug_class030106 microbiologyImmunologySocio-culturaleDrug PrescriptionsMicrobiologyOdds03 medical and health sciencesAntibiotic resistanceAnti-Bacterial AgentmedicineAntibiotic use; Internal medicine ward; Older people; Aged; Aged 80 and over; Anti-Bacterial Agents; Drug Prescriptions; Female; Geriatric Assessment; Hospital Mortality; Hospitalization; Humans; Italy; Logistic Models; Male; Multivariate Analysis; Prevalence; Registries; Respiratory Tract InfectionsHumansMedical prescriptionAntibiotic useGeriatric AssessmentAgedbusiness.industryConfidence intervalLogistic ModelsAntibiotic use Internal medicine ward Older peopleMultivariate AnalysisEmergency medicineOlder peopleOlder peoplebusinessAntibiotic use; Internal medicine ward; Older peopleJournal of Global Antimicrobial Resistance
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Disability, and not diabetes, is a strong predictor of mortality in oldest old patients hospitalized with pneumonia

2018

Abstract Background Pneumonia causes more deaths than any other infectious disease, especially in older patients with multiple chronic diseases. Recent studies identified a low functional status as prognostic factor for mortality in elderly patients with pneumonia while contrasting data are available about the role of diabetes. The aim of this study was to evaluate the in-hospital, 3-month and 1-year mortality in elderly subjects affected by pneumonia enrolled in the RePoSi register. Methods We retrospectively analyzed the data collected on hospitalized elderly patients in the frame of the REPOSI project. We analyzed the socio-demographic, laboratory and clinical characteristics of subjects…

Malemedicine.medical_specialtyMultivariate analysisBarthel indexSocio-culturaleComorbidity030204 cardiovascular system & hematologyDiabeteSeverity of Illness IndexComorbidity; Diabetes; Disability; Elderly; Pneumonia; Aged; Aged 80 and over; Comorbidity; Diabetes Mellitus; Disabled Persons; Female; Geriatric Assessment; Hospitalization; Humans; Italy; Logistic Models; Male; Multivariate Analysis; Pneumonia; Retrospective Studies; Risk Factors; Severity of Illness Index03 medical and health sciences0302 clinical medicineElderlyRisk FactorsDiabetes mellitusInternal medicineSeverity of illnessmedicine80 and overDiabetes MellitusInternal MedicineHumansDisabled Persons030212 general & internal medicineGeriatric AssessmentAgedRetrospective StudiesAged 80 and overDisabilitybusiness.industrySettore MED/09 - MEDICINA INTERNADiabetesRetrospective cohort studyOdds ratioPneumoniamedicine.diseaseOldest oldComorbidityPneumonia; Elderly; Disability; Diabetes; ComorbidityHospitalizationLogistic ModelsItalyMultivariate AnalysisFemaleComorbidity Diabetes Disability Elderly Pneumoniabusiness
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Factors affecting adherence to guidelines for antithrombotic therapy in elderly patients with atrial fibrillation admitted to internal medicine wards

2010

Abstract Introduction Current guidelines for ischemic stroke prevention in atrial fibrillation or flutter (AFF) recommend Vitamin K antagonists (VKAs) for patients at high-intermediate risk and aspirin for those at intermediate-low risk. The cost-effectiveness of these treatments was demonstrated also in elderly patients. However, there are several reports that emphasize the underuse of pharmacological prophylaxis of cardio-embolism in patients with AFF in different health care settings. Aims To evaluate the adherence to current guidelines on cardio-embolic prophylaxis in elderly (> 65 years old) patients admitted with an established diagnosis of AFF to the Italian internal medicine wards p…

Malemedicine.medical_specialtySettore MED/09 - Medicina InternaVitamin Kantithrombotic therapyNOAntithrombotic prophylaxis Atrial fibrillation Platelet agents Vitamin K antagonistsFibrinolytic AgentsRisk FactorsInternal medicineAntithromboticInternal MedicinemedicineHumansatrial fibrillationRegistriesMedical prescriptionStrokeAgedRetrospective StudiesAged 80 and overAntithrombotic prophylaxis; Atrial fibrillation; Platelet agents; Vitamin K antagonists;guidelines; antithrombotic therapy; atrial fibrillation.AspirinAspirinbusiness.industryantithrombotic prophylaxis; atrial fibrillation; platelet agents; vitamin k antagonistsAtrial fibrillationRetrospective cohort studyplatelet agentsmedicine.diseaseStrokevitamin k antagonistsIntracranial EmbolismItalyPlatelet aggregation inhibitorFemaleGuideline Adherenceantithrombotic prophylaxisbusinessguidelinePlatelet Aggregation InhibitorsFibrinolytic agentatrial fibrillation.medicine.drug
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Comparison of Disease Clusters in Two Elderly Populations Hospitalized in 2008 and 2010

2013

<b><i>Background:</i></b> As chronicity represents one of the major challenges in the healthcare of aging populations, the understanding of how chronic diseases distribute and co-occur in this part of the population is needed. <b><i>Objectives:</i></b> The aims of this study were to evaluate and compare patterns of diseases identified with cluster analysis in two samples of hospitalized elderly. <b><i>Methods:</i></b> Data were obtained from the multicenter ‘Registry Politerapie SIMI (REPOSI)' that included people aged 65 or older hospitalized in internal medicine and geriatric wards in Italy during 2008 and 2010. The s…

RegistrieMaleAgingCirrhosisSettore MED/09 - Medicina InternaTime FactorshispitalizationGerontology; aging populations;atterns of multimorbidity; diseases in the elderly population.Health care80 and overPrevalenceChronic diseases; Cluster analysis; Hospitalized elderlyRegistriesHospitalized elderlyaging populationAged 80 and overeducation.field_of_studySettore MED/45 - Scienze Infermieristiche Generali Cliniche E PediatricheHospitalizationItalyelderly; hispitalization; disease clustersFemaledisease clustershospitalizedHumanmedicine.medical_specialtyTime FactorAnemiaMULTIMORBIDITYPopulationMEDLINEMalignancyelderlyCluster analysisDiabetes mellitusInternal medicinedisease clusters; elderly; hospitalizedmedicinediseases in the elderly population.MultimorbidityHumansatterns of multimorbidityeducationAgedChronic diseases; Cluster analysis; Hospitalized elderly; Aged; Aged; 80 and over; Chronic Disease; Female; Hospitalization; Humans; Italy; Male; Prevalence; Registries; Time Factors; Cluster Analysis; Aging; Geriatrics and GerontologyCluster Analysibusiness.industrymedicine.diseaseChronic diseasesChronic DiseasePhysical therapydisease clusterGeriatrics and GerontologybusinessGerontologyChronic diseases; Cluster analysis; Hospitalized elderly; Aged; Aged 80 and over; Chronic Disease; Female; Hospitalization; Humans; Italy; Male; Prevalence; Registries; Time Factors; Cluster Analysis; Aging; Geriatrics and Gerontology
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Prevalence and Determinants of the Use of Lipid-Lowering Agents in a Population of Older Hospitalized Patients: the Findings from the REPOSI (REgistr…

2017

BACKGROUND: Older patients are prone to multimorbidity and polypharmacy, with an inherent risk of adverse events and drug interactions. To the best of our knowledge, available information on the appropriateness of lipid-lowering treatment is extremely limited. AIM: The aim of the present study was to quantify and characterize lipid-lowering drug use in a population of complex in-hospital older patients. METHODS: We analyzed data from 87 units of internal medicine or geriatric medicine in the REPOSI (Registro Politerapie della Società Italiana di Medicina Interna) study, with reference to the 2010 and 2012 patient cohorts. Lipid-lowering drug use was closely correlated with the clinical prof…

Malemedicine.medical_specialtyLogistic ModelLipid-Lowering AgentsPopulationSocio-culturaleOlder Hospitalized Patients030204 cardiovascular system & hematologyGeriatrics and Gerontology; Pharmacology (medical)03 medical and health sciences0302 clinical medicineInternal medicine80 and overPrevalencemedicineHumansPharmacology (medical)030212 general & internal medicineMedical prescriptionIntensive care medicineOmega 3 fatty acideducationAdverse effectAgedHypolipidemic AgentsAged 80 and overPolypharmacyGeriatricseducation.field_of_studyHypolipidemic Agentbusiness.industryGeriatrics and Gerontology Pharmacology (medical)HospitalizationLogistic ModelsCohortPolypharmacyAged; Aged 80 and over; Female; Hospitalization; Humans; Hypolipidemic Agents; Logistic Models; Male; Polypharmacy; Prevalence; Geriatrics and Gerontology; Pharmacology (medical)FemaleGeriatrics and GerontologybusinessAged; Aged 80 and over; Female; Hospitalization; Humans; Hypolipidemic Agents; Logistic Models; Male; Polypharmacy; PrevalenceHumanCohort study
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