Disability, and not diabetes, is a strong predictor of mortality in oldest old patients hospitalized with pneumonia

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RESEARCH PRODUCT

Disability, and not diabetes, is a strong predictor of mortality in oldest old patients hospitalized with pneumonia

S Corrao C Argano G Natoli A Nobili Gr Corazza Pm Mannucci F Perticone D Prisco E Silvestri G Emmi A Bettiol C Caterina G Biolo M Zanetti M Guadagni M Zaccari M Chiuch M Zaccari M Vanoli G Grignani Ea Pulixi M Bernardi Sl Bassi L Santi G Zaccherini G Lupattelli E Mannarino V Bianconi F Paciullo R Alcidi R Nuti R Valenti M Ruvio S Cappelli A Palazzuoli D Girelli F Busti G Marchi M Barbagallo L Dominguez F Cocita V Beneduce L Plances S Corrao G Natoli S Mularo M Raspanti F Cavallaro M Zoli I Lazzari M Brunori E Fabbri D Magalotti R Arno Fl Pasini Pl Capecchi G Palasciano Me Modeo C Di Gennaro Md Cappellini D Maira V Di Stefano G Fabio S Seghezzi M Mancarella Mm De Amicis G De Luca N Scaramellini Matteo Cesari Pd Rossi S Damanti M Clerici F Conti G Bonini Bb Ottolini A Di Sabatino E Miceli Mv Lenti M Pisati Cc Dominioni G Murialdo A Marra F Cattaneo R Pontremoli V Beccati G Nobili Mb Secchi D Ghelfi L Anastasio L Sofia M Carbone L Anastasio L Sofia M Carbone F Cipollone Mt Guagnano E Valeriani I Rossi G Mancuso D Calipari M Bartone G Delitala M Berria C Pes A Delitala M Muscaritoli A Molfino E Petrillo G Zuccala G D'aurizio G Romanelli A Marengoni A Zucchelli F Manzoni A Volpini A Picardi Uv Gentilucci P Gallo C Dell'unto G Annoni M Corsi G Bellelli S Zazzetta P Mazzola H Szabo A Bonfanti F Arturi E Succurro M Rubino B Tassone G Sesti Mg Serra Ma Bleve L Gasbarrone Mr Sajeva A Brucato S Ghidoni F Fabris I Bertozzi G Bogoni Mv Rabuini E Cosi P Scarinzi A Amabile E Omenetto T Prandini R Manfredini F Fabbian B Boari A De Giorgi R Tiseo R De Giorgio G Paolisso Mr Rizzo C Borghi E Strocchi E Ianniello M Soldati C Sabba Fs Vella P Suppressa P Agosti A Schilardi F Loparco Gm De Vincenzo A Comitangelo E Amoruso L Fenoglio A Falcetta C Bracco Al Fracanzani S Fargion S Tiraboschi A Cespiati G Oberti G Sigon F Peyvandi R Rossio B Ferrari G Colombo V Monzani V Savojardo C Folli G Ceriani F Salerno G Pallini F Dallegri L Ottonello L Liberale L Caserza K Salam Nl Liberato T Tognin Gb Bianchi S Giaquinto F Purrello Antonella Di Pino S Piro R Rozzini L Falanga E Spazzini C Ferrandina G Montrucchio P Petitti P Peasso E Favale C Poletto R Salmi P Gaudenzi F Violi L Perri Raffaele Landolfi Massimo Montalto A Mirijello L Guasti L Castiglioni A Maresca A Squizzato L Campiotti A Grossi M Bertolotti C Mussi G Lancellotti Mv Libbra G Dondi E Pellegrini L Carulli M Galassi Y Grassi F Perticone M Perticone R Battaglia M Filice R Maio V Stanghellini E Ruggeri S Del Vecchio A Salvi R Leonardi G Damiani W Capeci A Gabrielli M Mattioli Gp Martino L Biondi P Pettinari R Ghio A Dal Col S Minisola L Colangelo M Cilli G Labbadia A Afeltra B Marigliano Me Pipita P Castellino L Zanoli S Pignataro A Gennaro J Blanco V Saracco M Fogliati C Bussolino F Mete M Gino A Cittadini C Vigorito M Arcopinto A Salzano E Bobbio Am Marra D Sirico G Moreo F Gasparini S Prolo G Pina A Ballestrero F Ferrando S Berra S Dassi Mc Nava B Graziella S Baldassarre S Fragapani G Gruden G Galanti G Mascherini C Petri L Stefani M Girino V Piccinelli F Nasso V Gioffre M Pasquale G Scattolin S Martinelli M Turrin L Sechi C Catena G Colussi N Passariello L Rinaldi F Berti G Famularo P Tarsitani R Castello M Pasino Gp Ceda Mg Maggio S Morganti A Artoni S Del Giacco D Firinu F Losa G Paoletti G Costanzo G Montalto A Licata V Malerba Fa Montalto A Lasco G Basile A Catalano L Malatino B Stancanelli V Terranova S Di Marca R Di Quattro L La Malfa R Caruso P Mecocci C Ruggiero V Boccardi T Meschi F Lauretani A Ticinesi A Nouvenne P Minuz L Fondrieschi M Pirisi Gp Fra D Sola M Porta P Riva R Quadri E Larovere M Novelli G Scanzi C Mengoli S Provini L Ricevuti E Simeone R Scurti F Tolloso R Tarquini A Valoriani S Dolenti G Vannini A Tedeschi L Trotta R Volpi P Bocchi A Vignali S Harari C Lonati M Cattaneo Rd Nieves Mm Alberto Ar Pedro Lp Vanessa T Lara Cv Xavier F Francesc Dm Jesus Bt Esperanza Dcb Esther Sp Maria M Romero Pl Blanca Lgc Cristina Vgm Victoria L Saez J Bosco Sb Susana Ag Marta Gb Concepcion Fm Antonio Mg Hernandez Mp Borrego Pc Raquel Pr Florencia Go Beatriz Cg Sara Gcc Alfonso Pm Marta Rc Alberto Aa Antonio Gg Montserrat Brm Angel Mj Manuel Nv Ignacio As Lucia L Alfonso Rb David Vi Iniguez Rp Monica

subject

Male medicine.medical_specialty Multivariate analysis Barthel index Socio-culturale Comorbidity 030204 cardiovascular system & hematology Diabete Severity of Illness Index Comorbidity; Diabetes; Disability; Elderly; Pneumonia; Aged; Aged 80 and over; Comorbidity; Diabetes Mellitus; Disabled Persons; Female; Geriatric Assessment; Hospitalization; Humans; Italy; Logistic Models; Male; Multivariate Analysis; Pneumonia; Retrospective Studies; Risk Factors; Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Elderly Risk Factors Diabetes mellitus Internal medicine Severity of illness medicine 80 and over Diabetes Mellitus Internal Medicine Humans Disabled Persons 030212 general & internal medicine Geriatric Assessment Aged Retrospective Studies Aged 80 and over Disability business.industry Settore MED/09 - MEDICINA INTERNA Diabetes Retrospective cohort study Odds ratio Pneumonia medicine.disease Oldest old Comorbidity Pneumonia; Elderly; Disability; Diabetes; Comorbidity Hospitalization Logistic Models Italy Multivariate Analysis Female Comorbidity Diabetes Disability Elderly Pneumonia business

description

Abstract Background Pneumonia causes more deaths than any other infectious disease, especially in older patients with multiple chronic diseases. Recent studies identified a low functional status as prognostic factor for mortality in elderly patients with pneumonia while contrasting data are available about the role of diabetes. The aim of this study was to evaluate the in-hospital, 3-month and 1-year mortality in elderly subjects affected by pneumonia enrolled in the RePoSi register. Methods We retrospectively analyzed the data collected on hospitalized elderly patients in the frame of the REPOSI project. We analyzed the socio-demographic, laboratory and clinical characteristics of subjects with pneumonia. Multivariate logistic analysis was used to explore the relationship between variables and mortality. Results Among 4714 patients 284 had pneumonia. 52.8% were males and the mean age was 80 years old. 19.8% of these patients had a Barthel Index ≤40 (p ˂ 0.0001), as well as 43.2% had a short blessed test ≥10 (p ˂ 0.0117). In these subjects a significant CIRS for the evaluation of severity and comorbidity indexes (p ˂ 0.0001) were present. Although a higher fasting glucose level was identified in people with pneumonia, in the multivariate logistic analysis diabetes was not independently associated with in-hospital, 3-month and 1-year mortality, whereas patients with lower Barthel Index had a higher mortality risk (odds ratio being 9.45, 6.84, 19.55 in hospital, at 3 and 12 months). Conclusion Elderly hospitalized patients affected by pneumonia with a clinically significant disability had a higher mortality risk while diabetes does not represent an important determinant of short and long-term outcome.

year	journal	country	edition	language
2018-01-01

10.1016/j.ejim.2018.04.012 http://hdl.handle.net/10447/320365