0000000000139737
AUTHOR
R. Brachtel
Die intestinale Resorption von Digoxin bei Patienten mit progressiver Sklerodermie
Bei 18 Patienten mit progressiver Sklerodermie wurden Untersuchungen zur enteralen Resorption von Digoxin durchgefuhrt. Dazu erhielten 8 Patienten im Cross-over-Versuch eine einmalige intravenose und orale Gabe von 0,5 mg Digoxin. Beim Vergleich der Flachen unter der Plasmakonzentrations-Zeitkurve uber 8 Stunden fand sich bei 4 Patienten eine verminderte Digoxin-Resorption von weniger als 55% der Dosis. Bei allen 8 Patienten ergab sich eine statistisch signifikante positive Korrelation zwischen der D-Xylose- und der Digoxin-Resorption. Bei 12 Patienten wurden wahrend der Dauertherapie die Digoxinplasmaspiegel und die 24 h-Urinausscheidung des Glykosids an 3 aufeinanderfolgenden Tagen ermitt…
Psoriasis vulgaris and genetic markers
In a sample of n = 160 nonrelated male and female patients suffering from psoriasis Vulgaris, blood serum protein, and enzyme group typings have been carried out and compared with healthy controls from the same area (Rheinland-Pfalz). Marked statistically significant differences between patients and controls were found in none of the genetic blood polymorphisms considered here. However, combining previously published data from various authors with our own, significant associations between this skin disease and genetic polymorphisms such as MN, Gc, Gm (2), red cell acid phosphatase, and red cell phosphoglucomutase (PGM1) were seen. The possible reasons for these associations are discussed.
On the incidence of blood group O and Gm(-1) phenotypes in patients with malignant melanoma.
Fifteen polymorphic systems of the blood (ABO, MNSs, Rhesus, P, Kell, Duffy, Kidd, Hp, Gc, Gm, Inv, aP, PGM1, EsD, and 6-PGD) were examined in 191 unrelated male and female patients suffering from malignant melanoma. These polymorphic systems were compared with the corresponding phenotype and gene frequencies of controls from the same geographical area (Rhineland-Palatinate). The only associations discovered were the ABO and Gm polymorphisms: The incidence of O and Gm(-1) phenotypes in patients is obviously higher than in controls. These observations agree with the findings in other population samples from Germany and Bulgaria.
Associations between atopic diseases and the polymorphic systems ABO, Kidd, Inv and red cell acid phosphatase.
In 239 German patients with atopic conditions (atopic dermatitis, hay fever, allergic rhinitis, bronchial asthma, and acute urticaria) the phenotype and gene distribution of 15 genetic blood polymorphisms (ABO, MNSs, rhesus, P, Kell, Duffy, Kidd, Hp, Gc, Gm, Inv, aP, PGM1, EsD, and 6-PGD) were analyzed and compared with those in 151 selected controls (individuals clinically free of allergic conditions and without allergy in the family history). The incidence of blood group antigens A and B was somewhat higher in patients than in controls. These observations are in accordance with the results of previous studies in other populations. In addition, our observations favor the hypothesis that th…