0000000000154172

AUTHOR

Anne-marie Simonin

showing 4 related works from this author

N-3 fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring.

2006

We investigated the role of dietary n-3 polyunsaturated fatty acids (n-3 PUFA) in the modulation of total antioxidant status in streptozotocin (STZ)-induced diabetic rats and their macrosomic offspring. Female wistar rats, fed on control diet or n-3 PUFA diet, were rendered diabetic by administration of five mild doses of STZ on day 5 and were killed on days 12 and 21 of gestation. The macrosomic (MAC) pups were killed at the age of 60 and 90 days. Lipid peroxidation was measured as the concentrations of plasma thiobarbituric acid reactive substances (TBARS), and the total antioxidant status was determined by measuring (i) plasma oxygen radical absorbance capacity (ORAC), (ii) plasma vitami…

Vitaminmedicine.medical_specialtyAntioxidantErythrocytesOxygen radical absorbance capacityEndocrinology Diabetes and Metabolismmedicine.medical_treatmentPregnancy in DiabeticsMedicine (miscellaneous)Ascorbic AcidThiobarbituric Acid Reactive SubstancesAntioxidantsDiabetes Mellitus ExperimentalFetal MacrosomiaLipid peroxidationchemistry.chemical_compoundPregnancyInternal medicineFatty Acids Omega-3TBARSmedicineDiabetes MellitusAnimalsVitamin ERats WistarVitamin Achemistry.chemical_classificationGlutathione PeroxidaseNutrition and DieteticsVitamin CTriglycerideChemistrySuperoxide DismutaseFatty AcidsFree Radical ScavengersLipidsRatsEndocrinologyAnimals NewbornDiabetes Mellitus Type 2FemaleLipid PeroxidationBiomarkersPolyunsaturated fatty acidInternational journal of obesity (2005)
researchProduct

Effects of Zizyphus lotus L. (Desf.) polyphenols on Jurkat cell signaling and proliferation.

2013

We assessed the effects of Zizyphus lotus L. (Desf.) polyphenols (ZLP) on T-cell signaling and proliferation. Our results showed that ZLP exerted no effect on the increases in intracellular free calcium concentrations, [Ca(2+)]i, in human Jurkat T-cells. However, ZLP modulated the thapsigargin-induced increases in [Ca(2+)]i in these cells. ZLP treatment was found to decrease the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2). In addition, ZLP induced a rapid (t1/2=33s) and dose-dependent decrease in intracellular pH (pHi) in human Jurkat T-cells. Furthermore, ZLP significantly curtailed T-cell proliferation by diminishing their progression from S to G2/M phase of cell…

Cell signalingIntracellular pHT-LymphocytesImmunologychemistry.chemical_elementCalciumBiologyJurkat cellsJurkat CellsExtracellularImmunology and AllergyHumansCalcium SignalingRNA MessengerExtracellular Signal-Regulated MAP KinasesCell ProliferationPharmacologyImmunosuppression TherapyInflammationKinasePolyphenolsZiziphusCell cycleCell biologyBiochemistrychemistryGene Expression RegulationFruitPhosphorylationInterleukin-2ThapsigarginInternational immunopharmacology
researchProduct

STIM1, CD36 lingual et perception gustative lipidique

2012

> Selon l’Organisation mondiale de la sante (OMS) [1], l’obesite atteint des proportions epidemiques dans le monde, avec plus de 1,6 milliards d’adultes en surpoids et au moins 500 millions de personnes cliniquement obeses. Globalement, un adulte sur dix est obese dans le monde. Cette situation a des consequences importantes en termes de sante publique. En effet, l’obesite, particulierement l’obesite viscerale, est un facteur de risque de pathologies telles que le diabete de type II, les atteintes cardiovasculaires, l’hypertension et certaines formes de cancers [2]. Bien qu’il existe un determinisme genetique, les facteurs environnementaux dont l’alimentation jouent un role important dans l…

Gynecologymedicine.medical_specialtymedicineGeneral MedicineBiologyGeneral Biochemistry Genetics and Molecular Biologymédecine/sciences
researchProduct

Zizyphus lotus L. (Desf.) modulates antioxidant activity and human T-cell proliferation

2009

Abstract Background Zizyphus lotus L. (Desf.) also known as Jujube, is a deciduous shrub which belongs to Rhamnaceae family. This plant is used in Algerian traditional medicine for its anti-diabetic, sedative, analgesic, anti-inflammatory and hypoglycaemic activities. In the present study, we determined the concentrations of different vitamins (vitamin A, C and E) and fatty acids in root, stem, leaves, fruit pulp and seed of Zizyphus lotus L. (Desf.) and assessed the effects of their aqueous extracts on antioxidant status and human T-cell proliferation. Methods Aqueous filtrates from different parts, i.e, root, leaf, stem, fruit pulp and seed, of Zizyphus lotus L. (Desf.) were prepared. Vit…

VitaminAntioxidantLinolenic acidT-LymphocytesLinoleic acidmedicine.medical_treatmentGene ExpressionAscorbic AcidLymphocyte ActivationAntioxidantsCell LineLinoleic Acidchemistry.chemical_compoundBotanymedicineHumansVitamin EMicronutrientsFood scienceVitamin AbiologyVitamin CPlant ExtractsVitamin Efood and beveragesZiziphuslcsh:Other systems of medicineGeneral MedicineZiziphuslcsh:RZ201-999biology.organism_classificationAscorbic acidComplementary and alternative medicinechemistryFruitInterleukin-2Plant StructuresImmunosuppressive AgentsResearch Article
researchProduct