391MO Impact of diabetes and metformin use on recurrence and outcome in early colon cancer (CC) patients: A pooled analysis of 3 adjuvant trials

Primary-residue production cross sections and kinetic energies in 1AGeV 208Pb on deuteron reactions

Abstract The production cross sections and the kinematical properties of primary residual nuclei have been studied in the reaction 208 Pb(1  A  GeV)+d. Isotopic distributions were measured for all elements from titanium ( Z =22) to lead ( Z =82). The measured kinematical properties of the residues were also used to disentangle the relevant reaction mechanisms, spallation–evaporation and spallation–fission. The fragment separator FRS at GSI, Darmstadt, was used to separate and identify the reaction products. The measured quantities are important for the design and planning of future radioactive-beam facilities and accelerator-driven systems. The measured data of the present work are comprehe…

Experimental study of fragmentation products in the reactions112Sn+112Snand124Sn+124Snat 1AGeV

Production cross sections and longitudinal velocity distributions of the projectilelike residues produced in the reactions ${}^{112}\text{Sn}+{}^{112}\text{Sn}$ and ${}^{124}\text{Sn}+{}^{124}\text{Sn}$, both at an incident beam energy of 1$A$ GeV, were measured with the high-resolution magnetic spectrometer, the Fragment Separator of GSI. For both reactions the characteristics of the velocity distributions and nuclide production cross sections were determined for residues with atomic number $Z\ensuremath{\ge}10$. A comparison of the results of the two reactions is presented.

Association Between Tumor Egfr and Kras Mutation Status and Clinical Outcomes in Nsclc Patients Randomized to Sorafenib Plus Best Supportive Care (BSC) or Bsc Alone: Subanalysis of the Phase III Mission Trial

ABSTRACT Background Tumor EGFR and KRas mutations are both predictive and prognostic biomarkers in patients with advanced NSCLC. We analyzed the correlation between these biomarkers and treatment outcomes in a phase III trial of 3rd/4th line sorafenib in patients with NSCLC. Methods The global, randomized, placebo-controlled MISSION trial enrolled 703 patients with advanced relapsed/refractory NSCLC of predominantly non-squamous histology. The primary study endpoint was overall survival (OS). EGFR and KRas mutations were analyzed in archival tumor samples and in circulating tumor DNA isolated from plasma. Results Tumor and/or plasma mutation data were available from 347 patients (49%). EGFR…

Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry

Abstract Background Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients’ clinical phenotypes and analyse the differential clinical course. Methods We performed a hierarchical cluster analysis based on Ward’s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results A total of 9363 were available for this analysis. We identified three …

The electronion scattering experiment ELISe at the International Facility for Antiproton and Ion Research (FAIR) - A conceptual design study

The electronion scattering experiment ELISe is part of the installations envisaged at the new experimental storage ring at the International Facility for Antiproton and Ion Research (FAIR) in Darmstadt, Germany. It offers an unique opportunity to use electrons as probe in investigations of the structure of exotic nuclei. The conceptual design and the scientific challenges of ELISe are presented. © 2011 Elsevier B.V. All rights reserved.

Measurements of Spallation Residues Using Inverse Kinematics at GSI

The production cross sections and the kinematical properties of primary residual nuclei have been studied in reactions 197Au + p, 208Pb + p, d, 238U + p, d, and 238U + 208Pb at energies around 1 A GeV. The measured kinematical properties of the residues were also used to disentangle the relevant reaction mechanisms, spallation-evaporation and spallation-fission. The fragment separator FRS at GSI, Darmstadt, was used to separate and identify the reaction products. The measured quantities are important for the design and planning of future radioactive-beam facilities and accelerator-driven systems.