0000000000161227
AUTHOR
G Witzke
showing 5 related works from this author
POST-OPERATIVE CHANGES IN FACTOR XIII and FIBRCNETITN
1987
Wound healing processes after surgery are not restricted to certain areas tut affect the vhole body; the ooagulaticn systan in particular is involved. We studied Factor XIII and fibrcnectin in the blood plasma of 16 patients before surgery, after surgery and cn the 1st, 3rd and 7th days after surgery; fibrcnectin was determined using IC-Partigen iimunodiffusicn and Factor XIII by Behringwerke rapid test. In 11 patients normal wound healing was observed (group A), while in 5 patients explications oocured (group B). Factor XIII: normal group (A): fall in concentration oenpared with the precpera-tive value up to the 7th day after surgery; group with explications (B): fall in concentration more…
Hereditary angioneurotic oedema and blood-coagulation: interaction between C1-esterase-inhibitor and the activation factors of the proteolytic enzyme…
1983
C-1-inactivator (C-1-INA) does not only exert its important inhibitory functions in the complement system but also in the first step in the activation of the coagulation, fibrinolytic and kallikrein system. We therefore determined in nine patients with hereditary angioneurotic oedema (HANE) with obvious quantitative or functional defects of C-1-INA, and one further patient with Quincke-type oedema of different origin, the coagulation factors of the initial phase such as Hageman factor, plasma thromboplastin antecedent (PTA) and high molecular weight kininogen (HMWK). These factors were further correlated with the concentration as well as functional activity of C-1-INA. Nine of ten patients …
Interaction between C1-INA, coagulation, fibrinolysis and kinin system in hereditary angioneurotic edema (HANE) and urticaria.
1984
The C1-inactivator plays an important role not only in the initial phases of the complement system, but also in those of the coagulation, fibrinolysis and kinin systems. The present study was concerned with the reciprocal influence of decreased C1-inactivator levels in patients with hereditary angioneurotic edema (HANE, HAE). In 13 HANE-I patients there were significantly increased levels of the coagulation factors XII, XI, V, of plasminogen and of alpha 2-antiplasmin, while the factors IX and VII were decreased. Conversely, it emerged that in patients with markedly raised prephase factor levels, angioneurotic edema occurred in the presence of normal or only slightly decreased C1-inactivato…
POST-OPERATTVE CHANGES IN PROIEINASE INHIBITORS IN NORMAL AND IMPAIRED WOUND HEALING
1987
Tissue trauma after surgery activates blood coagulation. This results in a change and in the consumption of important inhibitors.We investigated the oonoentraticn of antithrorfoin III (AT III), ∝ 1-antitrypsin (∝l-AT), ∝ 2- macrogloublin (∝ 2-M) and Cl-inactivator (Cl-INH) in the blood plasma by means ofradial iirmunodiffusicn in 16 patients before surgery, after surgery and cn the 1st, 3rd and 7th days after surgery. In 11 patients normal wound healing wasobserved (group A), while in 5 patients amplicationsoccurred (group B). AT III: Fall in concentration upto the 3rd day after surgery, then a rise in concentration. In the patients with impaired wound healing there was a particularly marke…
Coagulation factors and proteinase inhibitors in the plasma of children with acute lymphoblastic leukoses. Behaviour before and during treatment acco…
1984
The thrombocyte count, the factor XIII (F XIII) activity, the concentration of fibrinogen (F I), prothrombin (F II), fibronectin (CIG), albumin and the proteinase inhibitors antithrombin III (AT III), alpha 2-macroglobulin (A2M), alpha 1-antitrypsin (A1A) and Cl-esterase inactivator (Cl-INA) were determined in ten children with acute lymphoblastic leukaemia (ALL). Changes due to the disease and to therapy were observed. Before the start of treatment the patients had thrombocytopenia secondary to the disease, and the proteinase inhibitors--especially Cl-INA and A1A--were raised. During the induction phase the thrombocyte count rose but there was also a marked increase in the concentration of…