6533b822fe1ef96bd127d5ca

RESEARCH PRODUCT

POST-OPERATTVE CHANGES IN PROIEINASE INHIBITORS IN NORMAL AND IMPAIRED WOUND HEALING

subject

description

Tissue trauma after surgery activates blood coagulation. This results in a change and in the consumption of important inhibitors.We investigated the oonoentraticn of antithrorfoin III (AT III), ∝ 1-antitrypsin (∝l-AT), ∝ 2- macrogloublin (∝ 2-M) and Cl-inactivator (Cl-INH) in the blood plasma by means ofradial iirmunodiffusicn in 16 patients before surgery, after surgery and cn the 1st, 3rd and 7th days after surgery. In 11 patients normal wound healing wasobserved (group A), while in 5 patients amplicationsoccurred (group B). AT III: Fall in concentration upto the 3rd day after surgery, then a rise in concentration. In the patients with impaired wound healing there was a particularly marked reduction in AT III cn the 3rd day.∝ 1-AT: Fall in concentration after surgery, followed by a rise in concentration. In impaired wound healing a lower mean value was determined on the 3rd day after surgery than in normal wound healing. ∝ 2-M: Fall in concentration up to the 3rd day after surgery, followed by a slight increase in concentration. No striking difference between the normal group and the group with complications. Cl-INH: Fall in concentration after surgery, followed by arise in concentration; in the patients with impaired wound healing there was adelayed rise in concentration.