0000000000177568

AUTHOR

Shamima N. Akhi

showing 4 related works from this author

The effect of warm ischemia at uterus transplantation in a rat model

2012

Objective Uterus transplantation (UTx) has been proposed as a method to treat women with absolute uterine factor infertility. The aim of this study was to evaluate the viability of the transplanted rat uterus after exposure to long warm ischemic times, in order to mimic a time frame likely to occur in a human situation during complicated pelvic vascular anastomosis surgery. Design Experimental study. Setting Obstetrics and Gynecology Department. Population Female Lewis rats. Methods. Pseudopregnant rats were randomly allocated into two intervention groups, a standardized syngeneic UTx procedure (control; n = 10) and a modified UTx protocol with a four hour extended period of warm ischemia (…

Infertilityeducation.field_of_studymedicine.medical_specialtyNecrosisbusiness.industryPopulationIschemiaUterusObstetrics and GynecologyGeneral Medicinemedicine.diseaseSurgeryTransplantationmedicine.anatomical_structureObstetrics and gynaecologyUterus transplantationmedicinemedicine.symptombusinesseducationActa Obstetricia et Gynecologica Scandinavica
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First report on fertility after allogeneic uterus transplantation

2010

Uterus transplantation may become the first available treatment for uterine factor infertility, which is due to the absence or malfunction of the uterus. Here we describe for the first time pregnancy after allogeneic uterus transplantation, as a proof of concept of uterine function in a transplanted uterus in a standardized animal model (rat) under immunosuppression.

Graft RejectionMaleInfertilitymedicine.medical_specialtymedia_common.quotation_subjectmedicine.medical_treatmentUterusFertilityTacrolimusRats Sprague-DawleyAnimal modelPregnancyUterus transplantationmedicineAnimalsTransplantation Homologousmedia_commonGynecologyPregnancyurogenital systembusiness.industryUterusObstetrics and GynecologyImmunosuppressionGeneral Medicinemedicine.diseaseRatsTransplantationFertilitysurgical procedures operativemedicine.anatomical_structureRats Inbred LewFemalebusinessInfertility FemaleImmunosuppressive AgentsActa Obstetricia et Gynecologica Scandinavica
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Pregnancy after syngeneic uterus transplantation and spontaneous mating in the rat.

2010

BACKGROUND: Uterus transplantation (UTx) research aims towards the introduction of UTx as a treatment for uterine factor infertility. The rat model is the principal rodent model used and this study aims to assess the potential for pregnancy and to assess effects on pregnancy outcome. METHODS: Female Lewis rats underwent hysterectomy and received syngeneic uterine transplants (with one horn removed) by end-to-side anastomosis between the common iliac vessels of the recipient and the graft. The graft was placed in an orthotopic position with anastomosis to the upper part of the native uterine horn and vagina to allow for pregnancy by mating. Controls had only one uterine horn removed. Mating …

Malemedicine.medical_specialtyPregnancy Ratemedicine.medical_treatmentUterusBiologyIliac VeinIliac ArteryRandom AllocationPregnancyUterus transplantationmedicineAnimalsBirth WeightGynecologyUterine DiseasesPregnancyHysterectomyRehabilitationAnastomosis SurgicalUterusPregnancy OutcomeObstetrics and GynecologyUterine hornsFetal Resorptionmedicine.diseaseRatsTransplantationPregnancy rateDisease Models AnimalTransplantation Isogeneicmedicine.anatomical_structureReproductive MedicineRats Inbred LewGestationFemaleInfertility FemaleHuman reproduction (Oxford, England)
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Uterine rejection after allogeneic uterus transplantation in the rat is effectively suppressed by tacrolimus

2013

Objective To evaluate the effects of the immunosuppressant tacrolimus on rejection of a transplanted uterus and on uterine expression of markers of inflammation and implantation. Design Experimental study. Setting University laboratory. Animal(s) Female rats. Intervention(s) Uteri from brown Norway rats were transplanted to Lewis rats, receiving either tacrolimus or no treatment. Sham groups underwent either hemihysterectomy or tacrolimus treatment. Main Outcome Measure(s) Gross morphology, histology, density of T-lymphocytes by immunohistochemistry, and mRNA levels of interleukin (IL)-1α, leukemia inhibitory factor (LIF), galectin-1, CD200, IL-15, interferon-inducible protein-10 (IP-10), a…

Graft Rejectionmedicine.medical_specialtyNecrosisGalectin 1UterusHysterectomyTacrolimusAndrologyNecrosisInterleukin-1alphaRats Inbred BNInternal medicineUterus transplantationmedicineAnimalsTransplantation HomologousInflammationbusiness.industryUterusObstetrics and GynecologyInterleukinHistologyOrgan TransplantationTacrolimusRatsChemokine CXCL10Transplantationsurgical procedures operativeEndocrinologymedicine.anatomical_structureReproductive MedicineRats Inbred LewFemalemedicine.symptombusinessLeukemia inhibitory factorBiomarkersImmunosuppressive AgentsFertility and Sterility
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