0000000000181186

AUTHOR

Svetlana Chapenko

showing 2 related works from this author

Association of human herpesvirus 6 and human herpesvirus 7 with demyelinating diseases of the nervous system.

2001

Peripheral blood mononuclear cells and plasma of 113 patients with neurological disorders and 150 blood donors were analyzed for HHV-6 and HHV-7 sequences by PCR. The prevalence of HHV-6 was significantly higher in patients with multiple sclerosis (P < 0.01) than in cases of nondemyelinating diseases of the central and demyelinating diseases of the peripheral nervous systems and blood donors. HHV-6 viremia was found only in patients with multiple sclerosis, predominantly in the active phase of the disease. A significantly higher frequency of HHV-7 reactivation in patients with demyelinating diseases of the peripheral nervous system suggests also its association with demyelinating processes.

Nervous systemAdultMalemedicine.medical_specialtyNeurologyMultiple SclerosisAdolescentvirusesHerpesvirus 6 HumanRoseolovirus InfectionsViremiaHerpesvirus 7 HumanDiseasePeripheral blood mononuclear cellPolymerase Chain ReactionCellular and Molecular NeuroscienceVirologyPrevalenceMedicineHumansViremiaAgedBrain Diseasesbiologybusiness.industryMultiple sclerosisvirus diseasesMiddle Agedmedicine.diseasebiology.organism_classificationmedicine.anatomical_structureNeurologyPeripheral nervous systemImmunologyDNA ViralHuman herpesvirus 6FemaleNeurology (clinical)businessJournal of neurovirology
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Correlation between HHV-6 reactivation and multiple sclerosis disease activity.

2002

This study examined the association between HHV-6 infection and multiple sclerosis (MS) and the relationship between HHV-6 reactivation and disease activity. The frequency of HHV-6 genomic sequences in peripheral blood mononuclear cells (PBMCs), the incidence of plasma viremia (nPCR), the transcription of viral mRNA in PBMCs (RT-PCR), the presence of antiviral IgM and IgG class antibodies in the plasma (IFA) of 16 relapsing/remitting and secondary progressive MS patients were studied in comparison with clinical manifestations of the disease, magnetic resonance imaging (MRI) of brain, and serum interleukin (IL)-12 concentrations (ELISA). The prevalence of HHV-6 infection was significantly hi…

ExacerbationvirusesHerpesvirus 6 HumanViremiaEnzyme-Linked Immunosorbent Assaymedicine.disease_causePeripheral blood mononuclear cellHerpesviridaeCentral nervous system diseaseMultiple Sclerosis Relapsing-RemittingVirologymedicineHumansCells Culturedbiologybusiness.industryReverse Transcriptase Polymerase Chain ReactionMultiple sclerosisvirus diseasesInterleukinHerpesviridae Infectionsmedicine.diseaseVirologyInfectious DiseasesImmunoglobulin MImmunoglobulin GImmunologybiology.proteinLeukocytes MononuclearVirus ActivationAntibodybusinessJournal of medical virology
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