6533b7d2fe1ef96bd125ec73
RESEARCH PRODUCT
Association of human herpesvirus 6 and human herpesvirus 7 with demyelinating diseases of the nervous system.
V TomsoneSvetlana ChapenkoInara LoginaAndrejs MillersS KozirevaModra Murovskasubject
Nervous systemAdultMalemedicine.medical_specialtyNeurologyMultiple SclerosisAdolescentvirusesHerpesvirus 6 HumanRoseolovirus InfectionsViremiaHerpesvirus 7 HumanDiseasePeripheral blood mononuclear cellPolymerase Chain ReactionCellular and Molecular NeuroscienceVirologyPrevalenceMedicineHumansViremiaAgedBrain Diseasesbiologybusiness.industryMultiple sclerosisvirus diseasesMiddle Agedmedicine.diseasebiology.organism_classificationmedicine.anatomical_structureNeurologyPeripheral nervous systemImmunologyDNA ViralHuman herpesvirus 6FemaleNeurology (clinical)businessdescription
Peripheral blood mononuclear cells and plasma of 113 patients with neurological disorders and 150 blood donors were analyzed for HHV-6 and HHV-7 sequences by PCR. The prevalence of HHV-6 was significantly higher in patients with multiple sclerosis (P < 0.01) than in cases of nondemyelinating diseases of the central and demyelinating diseases of the peripheral nervous systems and blood donors. HHV-6 viremia was found only in patients with multiple sclerosis, predominantly in the active phase of the disease. A significantly higher frequency of HHV-7 reactivation in patients with demyelinating diseases of the peripheral nervous system suggests also its association with demyelinating processes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-11-13 | Journal of neurovirology |