0000000000183525
AUTHOR
María Dolores Mauricio Aviñó
Contractile responses of human thyroid arteries to vasopressin
Aims: In the present study we investigated the intervention of nitric oxide and prostacyclin in the responses to vasopressin of isolated thyroid arteries obtained from multi-organ donors. Main methods: Paired artery rings from glandular branches of the superior thyroid artery, one normal and the other deendothelised, were mounted in organ baths for isometric recording of tension. Concentration-response curves to vasopressin were determined in the absence and in the presence of either the vasopressin V1 receptor antagonist d(CH2)5Tyr(Me)AVP (10−8 M), the nitric oxide synthase inhibitor NG-monomethyl-Larginine (L-NMMA, 10−4 M), or the inhibitor of prostaglandins indomethacin (10−6 M). Key fin…
Modulation of adrenergic responses of human vas deferens by K+ channel inhibitors
The results suggest that charybdotoxin-sensitive, but iberiotoxin-insensitive, K+ channels are activated by stimulation with norepinephrine and electrical field stimulation to counteract the adrenergic-induced contractions of human vas deferens. Thus, inhibition of these channels increases significantly the contraction, an effect that appears to be mediated by an increase in Ca2+ entry through L-type voltage-dependent Ca2+ channels.
Alteraciones vasculares en la insuficiencia renal crónica. Papel del endotelio.
RESUMEN El síndrome urémico resulta de la disminución marcada de la función renal. Este estado mantenido conduce a la insuficiencia renal crónica, que se define como la destrucción progresiva e irreversible de las nefronas. En la insuficiencia renal crónica se dan cita diferentes factores de riesgo cardiovascular, la propia uremia supone un factor de riesgo. La causa principal de morbi-mortalidad en estos pacientes deriva de alteraciones en el sistema cardiovascular. El tratamiento mediante hemodiálisis ha supuesto la prolongación de la vida para estos enfermos, pero a la vez, ha acarreado problemas relacionados con alteraciones cardiovasculares. En la presente tesis se estudian las vías de…
Nitric oxide mediates abnormal responsiveness of thyroid arteries in methimazole-treated patients
Objective: We studied the intervention of nitric oxide (NO), prostacyclin (PGI2) and endothelium-derived hyperpolarizing factor (EDHF) in mediating responses to acetylcholine in thyroid arteries from euthyroid (E) and methimazole-treated (MT) patients. Design and methods: Branches of the superior thyroid artery were obtained from 19 E patients and 17 MT patients (euthyroid at the time of surgery) undergoing total thyroidectomy or hemithyroidectomy. Artery rings were suspended in organ baths for isometric recording of tension. Results and conclusions: Acetylcholine caused endothelium-dependent relaxation of greater magnitude in arteries from MT patients (pD2 7.68±0.19 in E and 8.17±0.26 in M…
Accumulation of symetric dimethylarginine in hepatorenal syndrome.
In patients with cirrhosis, nitric oxide (NO), asymmetric dimethylarginine (ADMA), and possibly symmetric dimethylarginine (SDMA) have been linked to the severity of the disease. We investigated whether plasma levels of dimethylarginines and NO are elevated in patients with hepatorenal syndrome (HRS), compared with patients with cirrhosis without renal failure (no- HRS). Plasma levels of NO, ADMA, SDMA, and L-arginine were measured in 11 patients with HRS, seven patients with no-HRS, and six healthy volunteers. SDMA concentration in HRS was higher than in no-HRS and healthy subjects (1.47 6 0.25 vs. 0.38 6 0.06 and 0.29 6 0.04 lM, respectively; P , 0.05). ADMA and NOx concentrations were hi…
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