Oral and Poster Papers Submitted for Presentation at the 5th Congress of the EUGMS “Geriatric Medicine in a Time of Generational Shift September 3–6, 2008 Copenhagen, Denmark

Search for neutral Higgs bosons from supersymmetry in Z decays

The light scalar Higgs boson h and the pseudoscalar Higgs boson A of the minimal supersymmetric standard model have been searched for in the processes e+e−→hff and e+e−→hA using data collected by ALEPH at the LEP e+e− collider, with center of mass energies at and near the Z peak. Using a variety of signatures adapted to various mass ranges for h and A, we have excluded a large domain in the parameter space. For large values of ν2ν1, the ratio of the vacuum expectation values of the two Higgs fields, the whole range from 0 to 38.8 GeV is excluded for Mh and MA at 95% CL.

Searches for the standard Higgs boson

Abstract A data sample corresponding to about 100 000 hadronic Z decays collected by ALEPH at LEP has been used to search for the standard Higgs boson produced in the reaction e + e − → H 0 Z 0∗ . No indication for any signal was found, and a 95% CL lower limit on the Higgs boson mass has been set at 41.6 GeV.

Search for a new weakly interacting particle

Abstract A search for events of the type e + e − →l + l − X 0 , where X 0 can be any weakly interacting particle which couples to the Z, has been performed with the ALEPH detector at LEP, by searching for acollinear lepton pairs. Such particles can be excluded up to a mass of 7.0 GeV/c 2 for a value of the ratio of branching fractions, Br( Z →X 0 l + l − )/Br(Z→ l + l − ), greater than 2.5 × 10 −3 if the X 0 has third component of isospin, I 3 greater than 1 2 and decays to a pair of virtual gauge bosons. When this analysis is combined with the previous results of the Higgs particle searches from ALEPH, this limit can be extended to an X 0 mass of 60 GeV/c 2 .

Approche qualitative et phénoménologique du premier épisode psychotique : vécu traumatique et transformation identitaire, quelques résultats préliminaires

Resume But de l’etude Le premier episode psychotique constitue un evenement brutal pour les patients et s’accompagne d’une desorganisation psychique majeure avec une detresse importante. Plusieurs etudes recentes ont ainsi souligne la dimension traumatique du premier episode psychotique chez une large part des patients, et ont montre la prevalence du trouble de stress post-traumatique au sein de cette population. Toutefois, peu d’etudes ont porte leur attention sur cette dimension traumatique sous l’angle du vecu et de l’experience subjective des sujets confrontes au PEP, en dehors des criteres semiologiques du TSPT. Aussi, l’objectif de cette recherche consiste a investiguer de maniere app…

Search for excited leptons in Z0 decay

Due to the severity of system-wide power outages, though their probability of occurrence is slight, regulatory authorities require that a system restoration plan be drawn up and kept up to date at all times. The power outage that affected northeastern North America in 2003 proved the need for such a requirement. The particular structure of Hydro-Quebec's power system requires the use of a highly specific system restoration procedure. The daily preparation of the system restoration plan is based on a strategy whose application requires that a restoration sequence be drawn up that uses available equipment, the electrical behavior of which has been validated using appropriate studies. Over the…

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…

Search for supersymmetric particles using acoplanar charged-particle pairs from Z0 decays

We have performed a search for supersymmetric particles using acoplanar pairs of oppositely-charged particles in decays of the Z0. In 0.53 pb−1 of integrated luminosity near the Z0 peak, we observe two events where approximately four are expected from background, allowing limits to be extended on combined photino and slepton masses, and also on combined photino and chargino masses.

Association Between Tumor Egfr and Kras Mutation Status and Clinical Outcomes in Nsclc Patients Randomized to Sorafenib Plus Best Supportive Care (BSC) or Bsc Alone: Subanalysis of the Phase III Mission Trial

ABSTRACT Background Tumor EGFR and KRas mutations are both predictive and prognostic biomarkers in patients with advanced NSCLC. We analyzed the correlation between these biomarkers and treatment outcomes in a phase III trial of 3rd/4th line sorafenib in patients with NSCLC. Methods The global, randomized, placebo-controlled MISSION trial enrolled 703 patients with advanced relapsed/refractory NSCLC of predominantly non-squamous histology. The primary study endpoint was overall survival (OS). EGFR and KRas mutations were analyzed in archival tumor samples and in circulating tumor DNA isolated from plasma. Results Tumor and/or plasma mutation data were available from 347 patients (49%). EGFR…

Search for decays of the Z0 into a photon and a pseudoscalar meson

Abstract A search is reported for decays of the Z 0 into π 0 γ , ηγ and η ′ (958) γ in e + e − collisions using data collected during a scan around the Z 0 mass. In order to search for π 0 γ final states, in which the two photons from the π 0 decay are unresolved, the production of pairs of high-energy electromagnetic clusters is studied. The data are compared with the expectations from the pure QED process e + e − → γγ , and a 95% confidence level upper limit on the branching ratio of the Z 0 into π 0 γ of 4.9 × 10 −4 is derived. For η′γ, the decay modes of the mesons that contain two charged particles are largely free from QED background. These modes are used to place upper limits of 4.6 …

Worldwide comparison of ovarian cancer survival: Histological group and stage at diagnosis (CONCORD-2)

Abstract Objective Ovarian cancer comprises several histological groups with widely differing levels of survival. We aimed to explore international variation in survival for each group to help interpret international differences in survival from all ovarian cancers combined. We also examined differences in stage-specific survival. Methods The CONCORD programme is the largest population-based study of global trends in cancer survival, including data from 60 countries for 695,932 women (aged 15–99years) diagnosed with ovarian cancer during 1995–2009. We defined six histological groups: type I epithelial, type II epithelial, germ cell, sex cord-stromal, other specific non-epithelial and non-sp…

Early outcomes and complications following cardiac surgery in patients testing positive for coronavirus disease 2019: An international cohort study

The outbreak of severe acute respiratory syndromecoronavirus-2, the cause of coronavirus disease 2019 (COVID-19) in December 2019 represented a global emergency accounting for more than 2.5 million deaths worldwide.1 It has had an unprecedented influence on cardiac surgery internationally, resulting in cautious delivery of surgery and restructuring of services.2 Understanding the influence of COVID-19 on patients after cardiac surgery is based on assumptions from other surgical specialties and single-center studies. The COVIDSurg Collaborative conducted a multicenter cohort study, including 1128 patients, across 235 hospitals, from 24 countries demonstrating perioperative COVID-19 infection…

Abstracts from the 1st International Symposium on Decision Support in Anaesthesia and Intensive Care

Search for excited neutrinos in Z decay

Excited neutrinos decaying into a neutrino and a photon are searched for in the ALEPH detector at LEP. No evidence is found for Z decay into vv∗ or v∗v∗ final states. Upper limits are derived on excited neutrino couplings up to excited neutrino masses close to the Z mass. Lower limits on the v∗ mass, independent of the v∗ decay modes, are deduced from the total Z width.

Production and decay of charmed mesons at the Z resonance

Abstract In a sample of 190 000 hadronic Z decays, three signals of charm production are observed: two from the exclusive decays D ° → K − π + and D ∗+ → D °π + → K − π + π + and one in the transverse-momentum distribution of soft hadrons relative to the nearest jet. The features of these signals are in good agreement with expectations based on the standard model and previous measurements of the branching fractions. The number of D ∗± → K ± π ± π ± per hadronic decay of the Z is measured to be (5.11±0.34) × 10 −3 , and the branching ratio B(D 0 → K − π + ) is (3.62 ± 0.34 ± 0.44)%. Charm hadronization has been studied. The average fraction of the beam energy carried by the D ∗ meson is foun…

Automated source code transformations on fourth generation languages

To control the operation of large application suites or to tailor a special purpose application to particular need, developers frequently use application specific languages, such as batch, scripting, and query languages. These languages which are also referred to as fourth generation languages (4GLs) therefore play an important role in today's economy. Incompatibilities between different versions of 4GLs and changing requirements may make massive changes on a company's library of 4GL programs necessary. Here, we explore possibilities for performing mass changes on 4GLs and show how the transformation of programs written in 4GLs compares to the transformation of mainstream programming langua…

Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score

The British journal of surgery 108(11), 1274-1292 (2021). doi:10.1093/bjs/znab183

Light sterile neutrino sensitivity at the nuSTORM facility

A facility that can deliver beams of electron and muon neutrinos from the decay of a stored muon beam has the potential to unambiguously resolve the issue of the evidence for light sterile neutrinos that arises in short-baseline neutrino oscillation experiments and from estimates of the effective number of neutrino flavors from fits to cosmological data. In this paper, we show that the nuSTORM facility, with stored muons of 3.8 GeV/c $\pm$ 10%, will be able to carry out a conclusive muon neutrino appearance search for sterile neutrinos and test the LSND and MiniBooNE experimental signals with 10$\sigma$ sensitivity, even assuming conservative estimates for the systematic uncertainties. This…

ALEPH: a Detector for Electron-Positron Annihilations at LEP

Process-centred Software Engineering Environments (PSEE) are the most recent generation of environments supporting software development activities. Most of PSEE are based on mechanisms promoting enforcement and automation of process activities. In this kind of mechanisms the process models are prescribed in a detailed and complete way. But the experience shows that supporting processes is more concerned with the flexibility of guidance offered during the process performance than with enforcement of a collection of predefined process models. In this paper, we present a solution to support strategic processes in a PSEE by providing a flexible guidance during process enactment.

The clinical utility of PGD with HLA matching: a collaborative multi-centre ESHRE study

Study question Has PGD-HLA been successful relative to diagnostic and clinical efficacy? Summary answer The diagnostic efficacy of PGD-HLA protocols was found lower in this study in comparison to published PGD-HLA protocols and to that reported for general PGD by ESHRE (78.5 vs 94.1% and vs 92.6%, respectively), while the clinical efficacy has proven very difficult to assess due to inadequate follow-up of both the ART/PGD and HSCT procedure outcomes. What is known already The first clinical cases for PGD-HLA were reported in 2001. It is now a well-established procedure, with an increasing number of cycles performed every year. However, PGD-HLA is still offered by relatively few PGD centres,…

Worldwide comparison of survival from childhood leukaemia for 1995–2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries

BACKGROUND: Global inequalities in access to health care are reflected in differences in cancer survival. The CONCORD programme was designed to assess worldwide differences and trends in population-based cancer survival. In this population-based study, we aimed to estimate survival inequalities globally for several subtypes of childhood leukaemia. METHODS: Cancer registries participating in CONCORD were asked to submit tumour registrations for all children aged 0-14 years who were diagnosed with leukaemia between Jan 1, 1995, and Dec 31, 2009, and followed up until Dec 31, 2009. Haematological malignancies were defined by morphology codes in the International Classification of Diseases for …

Measurement of the B hadron lifetime

The average lifetime of B hadrons has been measured by the ALEPH experiment at LEP. Events containing B hadrons are selected by the identification of leptons with high transverse momentum in hadronic Z decays, and the lifetime is extracted from a fit to the impact parameter distribution of the lepton tracks. From a sample of 1.7×105 hadronic Z decays a lifetime of 1.29±0.06±0.10 ps is measured.

Measurement of B- mixing at the Z

Abstract From more than 175 000 hadronic Z decays observed with the ALEPH detector at LEP, we select 823 events with pairs of leptons in the final state. From these we measure χ , the probability thata b hadron which is observed to decay originated as a b hadron. We find χ =0.132 −0.026 +0.027 .

Measurement of the strong coupling constant alfa_s from global event-shape variables of hadronic Z decays

Abstract An analysis of global event-shape variables has been carried out for the reaction e+e−→Z0→hadrons to measure the strong coupling constant αs. This study is based on 52 720 hadronic events obtained in 1989/90 with the ALEPH detector at the LEP collider at energies near the peak of the Z-resonance. In order to determine αs, second order QCD predictions modified by effects of perturbative higher orders and hadronization were fitted to the experimental distributions of event-shape variables. From a detailed analysis of the theoretical uncertainties we find that this approach is best justified for the differential two-jet rate, from which we obtain αs(MZ2) = 0.121 ± 0.002(stat.)±0.003(s…