Syntheses, Structures and Reactivity of New Intramolecularly Coordinated Tin Alkoxides Based on an Enantiopure Ephedrine Derivative

The syntheses of the tin compounds [LSn]2 (2), spiro-L2Sn (3), [LSnW(CO)5]2 (4), [LSnBr2]2 (5), spiro-L2Sn·SnBr4 (6) and LSn[OC(O)Ph]2 (8), where L = MeN(CH2CMe2O)[(S)-CH(Me)-(R)-CH(Ph)O], and (Ph4P)2SnBr6 (7) are reported. The compounds were characterized by elemental analysis, multinuclear NMR spectroscopy including 119Sn cross polarisation–magic angle spinning NMR (CP–MAS) (2, 3–6), electrospray ionization mass spectrometry (2–4) and single crystal X-ray diffraction analysis (2, 2·C7H8, 3a, 3b, 4·C7H8, 5, 6·C7H8, 7).

Trapping Molecular SnBr 2 (OH) 2 by Tin Alkoxide Coordination: Syntheses and Molecular Structures of [MeN(CH 2 CMe 2 O) 2 SnBr 2 ] 2 ·SnBr 2 (OH) 2 and RN(CH 2 CMe 2 O) 2 SnL [R = Me, n ‐Octyl; L = Lone Pair, Cr(CO) 5 , W(CO) 5 , Fe(CO) 4 , Br 2 ]

The synthesis of the intramolecularly coordinated stannylenes and their transition-metal complexes of the type RN(CH2CMe2O)2SnL [1: L = lone pair, R = Me; 2: L = lone pair, R = n-octyl; 5: L =W(CO)5, R = Me; 6: L = Cr(CO)5, R = Me; 7: L =W(CO)5, R = n-octyl; 8: L = Fe(CO)4, R = Me], and of the tin(IV) compounds RN(CH2CMe2O)2SnBr2 (9: R = Me), [MeN(CH2CMe2O)2SnBr2]2·SnBr2(OH)2 (10) and spiro-[RN(CH2CMe2O)2]2Sn (3: R = Me; 4: R = n-octyl) is reported. The compounds were characterized by elemental analyses, 1H, 13C, 119Sn, and 119Sn magic-angle spinning (5, 6) NMR spectroscopy, electrospray mass spectrometry, and single-crystal X-ray diffraction analysis.

18F-labeling of peptides by means of an organosilicon-based fluoride acceptor.

Fluorine-18 is among the most commonly used radionuclides for positron emission tomography (PET). This non-invasive imaging technique is capable of providing in vivo information about the distribution of radiolabeled biomolecules by 1808 coincidence detection of two simultaneously emitted photons from positron–electron annihilation. Although a number of different radiotracers have been successfully employed in PET, only a few, such as 2-[F]fluoro-2-deoxy-d-glucose (FDG) and [F]fluorodopa, have gained widespread application in nuclear medicine. The reason for this is that the regioselective introduction of F into tracer molecules is often non-specific and radiochemical yields (RCY) of the Fl…

18F-Markierung von Peptiden mithilfe eines Organosilicium-Fluoridacceptors