0000000000218909

AUTHOR

David P. Serrano

showing 2 related works from this author

Efficacy and Safety of a Preemptive Antiviral Therapy Strategy Based on Combined Virological and Immunological Monitoring for Active Cytomegalovirus …

2016

Preemptive antiviral therapy for active CMV infection in allogeneic stem cell transplant recipients guided by immunological and virological parameters minimizes the risk of recurrent viremia in a subset of patients.

0301 basic medicineCongenital cytomegalovirus infectionViremiaContext (language use)DiseaseMajor Articles03 medical and health sciences0302 clinical medicineInterferonImmunityallogeneic stem cell transplantationimmunological monitoringMedicineIFN-γ CD8+ T cellscytomegalovirusbusiness.industryvirus diseasesmedicine.disease030104 developmental biologyInfectious DiseasesOncologypreemptive antiviral therapyImmunologyStem cellbusinessCD8030215 immunologymedicine.drugOpen forum infectious diseases
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Incidence, features, and outcomes of cytomegalovirus DNAemia in unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with …

2019

Background Conflicting data have been published as to the risk of cytomegalovirus (CMV) DNAemia and CMV disease in patients undergoing haploidentical hematopoietic stem cell transplantation (haplo-HSCT) with post-transplantation cyclophosphamide. Methods We conducted a multicenter retrospective study including 118 patients subjected to unmanipulated haplo-HSCT to further clarify this issue. An historic cohort comprising 165 patients undergoing other transplant modalities (HLA-matched related, matched unrelated or mismatched) was built for comparison purposes. Plasma CMV DNA monitoring was performed using two highly sensitive real-time PCR assays. Results Overall, the cumulative incidence of…

AdultMaleendocrine systemmedicine.medical_specialtyAdolescentCyclophosphamidemedicine.medical_treatmentCongenital cytomegalovirus infectionCytomegalovirusHematopoietic stem cell transplantationYoung AdultInternal medicinemedicineHumansTransplantation HomologousCumulative incidenceCyclophosphamideAgedRetrospective StudiesTransplantationbusiness.industryIncidenceIncidence (epidemiology)Hematopoietic Stem Cell Transplantationvirus diseasesRetrospective cohort studyCmv dnaemiaMiddle AgedViral Loadmedicine.diseasesurgical procedures operativeInfectious DiseasesSpainCytomegalovirus InfectionsDNA ViralCohortFemalebusinessImmunosuppressive Agentsmedicine.drugTransplant Infectious Disease
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