0000000000219390
AUTHOR
Bastian Greshake
openSNP–A Crowdsourced Web Resource for Personal Genomics
Genome-Wide Association Studies are widely used to correlate phenotypic traits with genetic variants. These studies usually compare the genetic variation between two groups to single out certain Single Nucleotide Polymorphisms (SNPs) that are linked to a phenotypic variation in one of the groups. However, it is necessary to have a large enough sample size to find statistically significant correlations. Direct-To-Consumer (DTC) genetic testing can supply additional data: DTC-companies offer the analysis of a large amount of SNPs for an individual at low cost without the need to consult a physician or geneticist. Over 100,000 people have already been genotyped through Direct-To-Consumer genet…
Additional file 6: of Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix
Snail collection sites. (PDF 330 kb)
Additional file 3: of Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix
Results and figure for the climate niche divergence PCA. (PDF 14 kb)
Additional file 1: of Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix
Results of the a) sequencing effort and b) assembly statistics. (PDF 257 kb)
Additional file 2: of Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix
Phylogenetic inference on species relationships. (PDF 255 kb)
Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix
AbstractBackgroundLife history traits like developmental time, age and size at maturity are directly related to fitness in all organisms and play a major role in adaptive evolution and speciation processes. Comparative genomic or transcriptomic approaches to identify positively selected genes involved in species divergence can help to generate hypotheses on the driving forces behind speciation. Here we use a bottom-up approach to investigate this hypothesis by comparative analysis of orthologous transcripts of four closely related EuropeanRadixspecies.ResultsSnails of the genusRadixoccupy species specific distribution ranges with distinct climatic niches, indicating a potential for natural …
Additional file 5: of Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix
Results enrichment analyses. (XLSX 11 kb)
Additional file 4: of Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix
Selected genes with annotations. (XLSX 35 kb)
Additional file 7: of Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix
Radix mt-genome primers. (XLS 36 kb)
Additional file 8: of Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix
Annotations and evolutionary models of the clusters used for phylogenetic inference. (XLSX 10 kb)
Data from: Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix
Background: Life history traits like developmental time, age and size at maturity are directly related to fitness in all organisms and play a major role in adaptive evolution and speciation processes. Comparative genomic or transcriptomic approaches to identify positively selected genes involved in species divergence can help to generate hypotheses on the driving forces behind speciation. Here we use a bottom-up approach to investigate this hypothesis by comparative analysis of orthologous transcripts of four closely related European Radix species. Results: Snails of the genus Radix occupy species specific distribution ranges with distinct climatic niches, indicating a potential for natural…