0000000000225928

AUTHOR

E. Thiering

showing 4 related works from this author

A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts

2016

OBJECTIVE: The aims of this study were to elucidate the influence of common genetic variants on childhood attention-deficit/hyperactivity disorder (ADHD) symptoms, to identify genetic variants that explain its high heritability, and to investigate the genetic overlap of ADHD symptom scores with ADHD diagnosis. METHOD: Within the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, genome-wide single nucleotide polymorphisms (SNPs) and ADHD symptom scores were available for 17,666 children (<13 years of age) from nine population-based cohorts. SNP-based heritability was estimated in data from the three largest cohorts. Meta-analysis based on genome-wide association (GWA) analyses w…

0301 basic medicineMaleNetherlands Twin Register (NTR)attention problemsPopulation/methodsCHILDHOODAdhd Symptoms ; Gwa ; Snp Heritability ; Attention Problems ; Meta-analysisGenome-wide association studyCHILDRENCohort Studies0302 clinical medicineDevelopmental and Educational PsychologyGENETIC INFLUENCESNETHERLANDS TWIN REGISTERChildGeneticsRISKeducation.field_of_studyGenetics Population/methods3. Good healthPsychiatry and Mental healthPERSONALITY CONSORTIUM/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingFemalePsychologyAttention Deficit Disorder with Hyperactivity/geneticsAdolescentDEFICIT HYPERACTIVITY DISORDERPopulationSingle-nucleotide polymorphismGWAPROFILEGenetic correlationADHD symptomsArticle150 000 MR Techniques in Brain FunctionSNP heritabilityBEHAVIOR PROBLEMS03 medical and health sciencesSDG 3 - Good Health and Well-beingmedicine/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_GeneticsSNPAttention deficit hyperactivity disorderADHDHumanseducationGenetic associationNeurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]Heritabilitymedicine.diseasemeta-analysis030104 developmental biologyGenetics PopulationTrastorn per dèficit d'atenció amb hiperactivitatAttention Deficit Disorder with HyperactivityCase-Control Studies030217 neurology & neurosurgeryGenèticaGenome-Wide Association Study
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Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes

2019

Importance: Both low and high gestational weight gain have been associated with adverse maternal and infant outcomes, but optimal gestational weight gain remains uncertain and not well defined for all prepregnancy weight ranges. Objectives: To examine the association of ranges of gestational weight gain with risk of adverse maternal and infant outcomes and estimate optimal gestational weight gain ranges across prepregnancy body mass index categories. Design, setting, and participants: Individual participant-level meta-analysis using data from 196 670 participants within 25 cohort studies from Europe and North America (main study sample). Optimal gestational weight gain ranges were estimated…

Gestational hypertensionNutrition and Disease01 natural sciencesBody Mass Index0302 clinical medicinePregnancyVoeding en ZiekteMedicineBirth Weight030212 general & internal medicineObstetricsDiabetesPregnancy OutcomeGestational ageGeneral MedicineCesarean Section/statistics & numerical dataAdult; Birth Weight; Cesarean Section; Diabetes Gestational; Female; Humans; Hypertension Pregnancy-Induced; Infant Newborn; Obesity; Pregnancy; Premature Birth; Body Mass Index; Gestational Weight Gain; Pregnancy Complications; Pregnancy OutcomeGestational Weight GainGestational diabetesPremature birthGestationalHypertensionPremature BirthFemalemedicine.symptomUnderweightPREGNANT-WOMENAdultmedicine.medical_specialtyBirth weightPregnancy-InducedHealthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]03 medical and health sciencesAll institutes and research themes of the Radboud University Medical CenterLife ScienceHumansObesity0101 mathematicsbusiness.industryCesarean Section010102 general mathematicsInfant NewbornInfantHypertension Pregnancy-Inducedmedicine.diseaseNewbornReconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]BODY-MASS INDEXPregnancy ComplicationsDiabetes GestationalbusinessBody mass indexWeight gain
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Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study.

2019

Key Points Question Is birth weight associated with type 2 diabetes and glycemic traits? Findings This mendelian randomization study found that a 1-SD decrease in birth weight due to the genetic risk score was associated with a higher risk of type 2 diabetes among European and East Asian populations. In addition, a 1-SD decrease in birth weight was associated with a 0.189-SD increase in fasting glucose concentration, but not with fasting insulin, 2-hour glucose, or hemoglobin A1c level. Meaning A genetic predisposition to lower birth weight was associated with an increased risk of type 2 diabetes and increased fasting glucose, suggesting potential mechanisms through which perturbation of th…

Blood GlucoseMaleType 2 diabetes0302 clinical medicineOdds RatioBirth WeightInsulin030212 general & internal medicineOriginal Investigation0303 health sciencesAsia EasternMendelian Randomization AnalysisGeneral MedicineMiddle Aged16. Peace & justice3. Good healthOnline OnlyDiabetes and EndocrinologyFemaletype 2 diabetesAdultmedicine.medical_specialtyDiabetes riskAdolescentBirth weightPolymorphism Single NucleotideWhite People03 medical and health sciencesYoung AdultSDG 3 - Good Health and Well-beingAsian PeopleDiabetes mellitusInternal medicineMendelian randomizationmedicineHumans030304 developmental biologyGlycemicAgedGlycated Hemoglobinbusiness.industryResearchInfant Newbornbirth weightGenetic VariationOdds ratioMendelian Randomization Analysismedicine.diseaseDiabetes Mellitus Type 2mendelian randomization studybusinessJAMA network open
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Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

2013

The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both the central onset of puberty and local growth factors. Although little is known about the underlying genetics, growth variability during puberty correlates with adult risks for hormone-dependent cancer and adverse cardiometabolic health. The only gene so far associated with pubertal height growth, LIN28B, pleiotropically influences childhood growth, puberty and cancer progression, pointing to shared underlying mechanisms. To discover genetic loci influencing pubertal height and growth and to place them in context of overall growth and maturation, we performed genome-wide association meta-analyses i…

MaleNetherlands Twin Register (NTR)Genetic LinkageMedizinGene ExpressionGenome-wide association studyVARIANTSBody Mass Index0302 clinical medicinegenetic linkageTransforming Growth Factor betaNeoplasmsmolecular biologygeneticsChildGenetics (clinical)Adiposity2. Zero hunger0303 health sciencesadiposityMitogen-Activated Protein Kinase 3Association Studies ArticlesAge FactorsACHONDROPLASIAGeneral MedicineGenome-Wide Association Study; pubertal height growth; pubertal timingPhenotypeOBESITYMenarche/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingbody heightFemaleSignal Transductionmedicine.medical_specialtyage factorsCHROMOSOME 16P11.2AdolescentBIRTHQuantitative Trait Loci030209 endocrinology & metabolismContext (language use)BiologyChildhood obesitypubertal height growthMENARCHEYoung Adult03 medical and health sciencesAGESDG 3 - Good Health and Well-beingPrepubertyInternal medicineGeneticsmedicine/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_HumansMolecular Biology030304 developmental biologySignMenarcheFACTOR RECEPTOR-3MUTATIONSpubertal timingPubertyta3121medicine.diseaseObesityBody HeightGenetic architectureEndocrinologyPOPULATION COHORTgene expressionBody mass indexFollow-Up StudiesGenome-Wide Association Study
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