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RESEARCH PRODUCT
Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study.
Kari E. NorthCécile LecoeurCécile LecoeurKatja PahkalaMeng GaoKim OvervadKim OvervadCyrus CooperCyrus CooperCyrus CooperLuis A. MorenoLuis A. MorenoKeith M. GodfreyKeith M. GodfreyWanting ZhaoSing Hui LimEmily SonestedtAlbert HofmanAlbert HofmanKaren A. JamesonZhe FangFrits R. RosendaalYih Chung ThamJean-paul LanghendriesJanine F. FelixTao HuangFrédéric GottrandWoon-puay KohTorben HansenLu QiLu QiHans BisgaardJorma ViikariJorma ViikariJianjun LiuJianjun LiuMarju Orho-melanderMeian HeBeverley BalkauXueling SimXiang LiPeter RzehakOluf PedersenPhilippe FroguelPhilippe FroguelDonna K. ArnettOscar ColtellOscar ColtellUlrika EricsonGeorge Davey SmithSeang-mei SawJoachim ThieryJoaquin EscribanoElvira VerduciTien Yin WongNadia R. FinkYujie WangEirini MarouliTiange WangTiange WangTiange WangYan ZhengYan ZhengChao-qiang LaiAline MeirhaegheColin BorehamDaniel I. ChasmanChiea Chuen KhorFrédéric FumeronFrédéric FumeronGraciela E. DelgadoKatherine L. TuckerDennis O. Mook-kanamoriDariush MozaffarianTuomas O. KilpeläinenJin-fang ChaiThorkild I. A. SørensenThorkild I. A. SørensenAndré G. UitterlindenOscar H. FrancoTrudy VoortmanJian-min YuanFrank J. A. Van RooijVincent W. V. JaddoeFernando RivadeneiraRebecca K. VindingAstrid SevelstedMasato AkiyamaHazel InskipHazel InskipDolores CorellaDolores CorellaJean DallongevilleRajkumar DorajooJose M. OrdovasTao ZhangTao ZhangDiana Van HeemstBlanche LimNanette R. LeeMichiaki KuboPreeti GuptaCaizheng YuMariaelisa GraffPeter RossingCarol A. WangCarol A. WangTarunveer S. AhluwaliaTarunveer S. AhluwaliaJorge E. ChavarroElaine M. DennisonElaine M. DennisonYik Ying TeoTerho LehtimäkiAlexis C. Frazier-woodChristina EllervikChris PowerMarie StandlChristina-alexandra SchulzDavid A. MackeyAnne TjønnelandPanagiotis DeloukasPanagiotis DeloukasRamon EstruchGeorge DedoussisNiina PitkänenPaul M. RidkerOlli T. RaitakariOlli T. RaitakariCharumathi SabanayagamMarkus LoefflerRob M. Van DamRaymond NoordamYoichiro KamataniWinfried MärzWinfried MärzWinfried MärzMarkus ScholzHarri NiinikoskiHarri NiinikoskiDariusz GruszfeldTangchun WuElina HyppönenElina HyppönenRozenn N. LemaitreMarcus E. KleberMarcus E. KleberBerthold KoletzkoE-shyong TaiVeit GroteKlaus BønnelykkeChing-yu ChengCarla M. T. TieslerKaren L. MohlkeE. ThieringRenée De MutsertAng ZhouMika KähönenLuc DjousséPhilippe AmouyelSarah CrozierRalph BurkhardtYuan ShiBruce M. Psatysubject
Blood GlucoseMaleType 2 diabetes0302 clinical medicineOdds RatioBirth WeightInsulin030212 general & internal medicineOriginal Investigation0303 health sciencesAsia EasternMendelian Randomization AnalysisGeneral MedicineMiddle Aged16. Peace & justice3. Good healthOnline OnlyDiabetes and EndocrinologyFemaletype 2 diabetesAdultmedicine.medical_specialtyDiabetes riskAdolescentBirth weightPolymorphism Single NucleotideWhite People03 medical and health sciencesYoung AdultSDG 3 - Good Health and Well-beingAsian PeopleDiabetes mellitusInternal medicineMendelian randomizationmedicineHumans030304 developmental biologyGlycemicAgedGlycated Hemoglobinbusiness.industryResearchInfant Newbornbirth weightGenetic VariationOdds ratioMendelian Randomization Analysismedicine.diseaseDiabetes Mellitus Type 2mendelian randomization studybusinessdescription
Key Points Question Is birth weight associated with type 2 diabetes and glycemic traits? Findings This mendelian randomization study found that a 1-SD decrease in birth weight due to the genetic risk score was associated with a higher risk of type 2 diabetes among European and East Asian populations. In addition, a 1-SD decrease in birth weight was associated with a 0.189-SD increase in fasting glucose concentration, but not with fasting insulin, 2-hour glucose, or hemoglobin A1c level. Meaning A genetic predisposition to lower birth weight was associated with an increased risk of type 2 diabetes and increased fasting glucose, suggesting potential mechanisms through which perturbation of the antenatal and early-life environment affect predisposition to diabetes in later life.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-09-01 | JAMA network open |