0000000000230918

AUTHOR

Olwen Domingo

showing 2 related works from this author

Studying RNA Using Single Molecule Fluorescence Resonance Energy Transfer

2014

Förster resonance energy transferResonance fluorescenceChemistryEnergy transferResonanceRNAEmission spectrumPhotochemistrySingle-molecule experimentPhotobleaching
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A modified guanosine phosphoramidite for click functionalization of RNA on the sugar edge

2012

A propargyl containing guanosine phosphoramidite was synthesized and incorporated into siRNA, enabling click-ligation with an azido fluorophore onto the nucleobase sugar edge. Duplex stability was not affected by labeling at this new site, which allowed deconvolution of the effects of label, structure and attachment site on RNAi activity.

PhosphoramiditeFluorophoreGuanosineMolecular StructureCarbohydratesMetals and AlloysGuanosineRNAGeneral ChemistryCombinatorial chemistryCatalysisSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsNucleobasechemistry.chemical_compoundOrganophosphorus CompoundschemistryDuplex (building)PropargylMaterials ChemistryCeramics and CompositesRNASurface modificationClick ChemistryRNA Small InterferingChemical Communications
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