0000000000235871

AUTHOR

Ann Wallin

showing 2 related works from this author

First report on fertility after allogeneic uterus transplantation

2010

Uterus transplantation may become the first available treatment for uterine factor infertility, which is due to the absence or malfunction of the uterus. Here we describe for the first time pregnancy after allogeneic uterus transplantation, as a proof of concept of uterine function in a transplanted uterus in a standardized animal model (rat) under immunosuppression.

Graft RejectionMaleInfertilitymedicine.medical_specialtymedia_common.quotation_subjectmedicine.medical_treatmentUterusFertilityTacrolimusRats Sprague-DawleyAnimal modelPregnancyUterus transplantationmedicineAnimalsTransplantation Homologousmedia_commonGynecologyPregnancyurogenital systembusiness.industryUterusObstetrics and GynecologyImmunosuppressionGeneral Medicinemedicine.diseaseRatsTransplantationFertilitysurgical procedures operativemedicine.anatomical_structureRats Inbred LewFemalebusinessInfertility FemaleImmunosuppressive AgentsActa Obstetricia et Gynecologica Scandinavica
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Viability and function of the cryopreserved whole rat ovary: comparison between slow-freezing and vitrification

2011

Objective To investigate four different protocols for cryopreservation of the whole rat ovary with intact vasculature to evaluate whether differences exist in post-thawing viability of the ovary after either vitrification or slow freezing. Design Experimental study. Setting Obstetrics and gynecology department. Animal(s) Immature Sprague-Dawley female rats. Intervention(s) Ovaries were isolated with the vascular tree intact up to the bifurcation of the abdominal aorta and were subsequently cannulated. The ovaries were flushed with increasing concentrations of the cryoprotectant dimethyl sulfoxide (DMSO) to either 1.5 or 7 M. The ovaries underwent cryopreservation by vitrification or passive…

medicine.medical_specialtyNeutral redTime FactorsCryoprotectantApoptosisOvaryBiologyCryopreservationRats Sprague-DawleyTissue Culture TechniquesAndrologychemistry.chemical_compoundCryoprotective AgentsOvarian FollicleFreezingFollicular phasemedicineAnimalsDimethyl SulfoxideVitrificationIncubationCryopreservationTissue SurvivalGynecologyDose-Response Relationship DrugEstradiolCaspase 3Dimethyl sulfoxideOvaryFertility PreservationObstetrics and GynecologyOrgan PreservationImmunohistochemistryVitrificationRatsPerfusionmedicine.anatomical_structureReproductive MedicinechemistryFemaleFertility and Sterility
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