Acute hepatotoxicity induced by quetiapine fumarate in larval zebrafish

Ultraprecise Rydberg atomic localization using optical vortices

We propose a robust localization of the highly-excited Rydberg atoms, interacting with doughnut-shaped optical vortices. Compared with the earlier standing-wave (SW)-based localization methods, a vortex beam can provide an ultrahigh-precision two-dimensional localization solely in the zero-intensity center, within a confined excitation region down to the nanometer scale. We show that the presence of the Rydberg-Rydberg interaction permits counter-intuitively much stronger confinement towards a high spatial resolution when it is partially compensated by a suitable detuning. In addition, applying an auxiliary SW modulation to the two-photon detuning allows a three-dimensional confinement of R…

Strongly confined atomic localization by Rydberg coherent population trapping

In this letter we investigate the possibility to attain strongly confined atomic localization using interacting Rydberg atoms in a Coherent Population Trapping (CPT) ladder configuration, where a standing-wave (SW) is used as a coupling field in the second leg of the ladder. Depending on the degree of compensation of the Rydberg level energy shift induced by the van der Waals (vdW) interaction, by the coupling field detuning, we distinguish between two antiblockade regimes, i.e. a partial antiblockade (PA) and a full antiblockade (FA). While a periodic pattern of tightly localized regions can be achieved for both regimes, the PA allows much faster converge of spatial confinement yielding a …

Biomarker discovery study of inflammatory proteins for colorectal cancer early detection demonstrated importance of screening setting validation

Abstract Objectives Most studies identifying inflammatory markers for early detection of colorectal cancer (CRC) were conducted using clinically manifest cases. We aimed to identify circulating inflammatory biomarkers for early detection of CRC and validate them in both a clinical setting and a true screening setting. Study Design and Setting A total of 92 inflammatory proteins were quantified in baseline plasma samples from individuals clinically diagnosed with CRC and neoplasm-free controls matched on age and sex (training set). A multimarker panel was selected and evaluated in samples from another clinical setting (validation set C) and a screening setting (validation set S). Results In …