Deleghe di poteri e responsabilità

Le concrete esigenze imprenditoriali consistenti nel bisogno di strutturare le società in centri decisionali che siano in grado di compiere scelte operative tempestive e dimostrare, all’occorrenza, specializzazione nell’esercizio di funzioni strategiche, nonché le relative attenzioni ad esse recentemente dedicate da parte del legislatore, ma anche di Autori e giurisprudenza, si pongono a fondamento della scelta di trattare della delega di poteri, quale tipica modalità di organizzazione della gestione pluripersonale delle società in epoca odierna, e delle responsabilità derivanti dal suo esercizio. Si da atto dell’incisività del contributo apportato dalla riforma organica delle società di ca…

Developmental toxicity and epigenetic changes induced by pharmaceuticals in zebrafish (Danio rerio)

Epigenetic Modulation of Chromatin States and Gene Expression by G-Quadruplex Structures

G-quadruplexes are four-stranded helical nucleic acid structures formed by guanine-rich sequences. A considerable number of studies have revealed that these noncanonical structural motifs are widespread throughout the genome and transcriptome of numerous organisms, including humans. In particular, G-quadruplexes occupy strategic locations in genomic DNA and both coding and noncoding RNA molecules, being involved in many essential cellular and organismal functions. In this review, we first outline the fundamental structural features of G-quadruplexes and then focus on the concept that these DNA and RNA structures convey a distinctive layer of epigenetic information that is critical for the c…

Composition and geographic variation of the bacterial microbiota associated with the coelomic fluid of the sea urchin Paracentrotus lividus

AbstractIn the present work, culture-based and culture-independent investigations were performed to determine the microbiota structure of the coelomic fluid of Mediterranean sea urchin Paracentrotus lividus individuals collected from two distinct geographical sites neighboring a high-density population bay and a nature reserve, respectively. Next Generation Sequencing analysis of 16S rRNA gene (rDNA) showed that members of the Proteobacteria, Bacteroidetes and Fusobacteria phyla, which have been previously reported to be commonly retrieved from marine invertebrates, dominate the overall population of microorganisms colonizing this liquid tissue, with minority bacterial genera exhibiting rem…