0000000000247761
AUTHOR
Jaume Bertranpetit
Identifying Genetic Traces of Historical Expansions: Phoenician Footprints in the Mediterranean
10 páginas, 1 figura, 4 páginas.-- et al.
Additional file 1: of Gene connectivity and enzyme evolution in the human metabolic network
Figure S1. Reaction graph generated from the human metabolic network reconstruction Recon3D. Figure S2. Distribution of the selection estimates calculated for genes with 1:1 orthologs in the 6 species (Human, Chimpanzee, Gorilla, Orangutan, Mouse, and Rat) in the global metabolic network. Figure S3. Correlation matrices between variables. Figure S4. Relationship between selection estimates and connectivity (degree, in-degree and out-degree) in the global metabolic network. Figure S5. Relationship between selection estimates and position. Figure S6. Number of genes under positive selection in each functional pathway of the global metabolic network. Figure S7. Distribution of the number of en…
Evidence for a common origin of most Friedreich ataxia chromosomes in the Spanish population
Haplotype analysis is a powerful approach to understand the spectrum of mutations accounting for a disease in a homogeneous population. We show that haplotype variation for 10 markers linked to the Friedreich ataxia locus (FRDA) argues in favor of an important mutation homogeneity in the Spanish population, and positions the FRDA locus in the region where it has been recently isolated. We also report the finding of a new single nucleotide polymorphism called FAD1. The new marker shows a very strong linkage disequilibrium with Friedreich ataxia (FA) in both the Spanish and French populations. suggesting the existence of an ancient and widespread FRDA mutations. Inclusion of FAD1 in the exten…
The genome sequencing of an albino Western lowland gorilla reveals inbreeding in the wild
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.-- et al.
Gene connectivity and enzyme evolution in the human metabolic network
[Background] Determining the factors involved in the likelihood of a gene being under adaptive selection is still a challenging goal in Evolutionary Biology. Here, we perform an evolutionary analysis of the human metabolic genes to explore the associations between network structure and the presence and strength of natural selection in the genes whose products are involved in metabolism. Purifying and positive selection are estimated at interspecific (among mammals) and intraspecific (among human populations) levels, and the connections between enzymatic reactions are differentiated between incoming (in-degree) and outgoing (out-degree) links.
Influence of pathway topology and functional class on the molecular evolution of human metabolic genes
Metabolic networks comprise thousands of enzymatic reactions functioning in a controlled manner and have been shaped by natural selection. Thanks to the genome data, the footprints of adaptive (positive) selection are detectable, and the strength of purifying selection can be measured. This has made possible to know where, in the metabolic network, adaptive selection has acted and where purifying selection is more or less strong and efficient. We have carried out a comprehensive molecular evolutionary study of all the genes involved in the human metabolism. We investigated the type and strength of the selective pressures that acted on the enzyme-coding genes belonging to metabolic pathways …
Additional file 2: of Gene connectivity and enzyme evolution in the human metabolic network
Table S1. Reaction graph. List of edges of the directed reaction graph generated formed by the giant connected component of Recon3D. Table S2. Genes under positive selection in the global metabolic network. Table S3. Genes under recent positive selection in individual metabolic pathways. Table S4. Connectivity of metabolic genes under positive selection compared to the rest of metabolic genes in individual metabolic pathways. Table S5. Global metabolic network giant connected component gene/reaction information. Table S6. Individual metabolic pathways gene/reaction information. (XLSX 4140 kb)